KEGG   ENZYME: 1.12.2.1Help
Entry
EC 1.12.2.1                 Enzyme                                 

Name
cytochrome-c3 hydrogenase;
H2:ferricytochrome c3 oxidoreductase;
cytochrome c3 reductase;
cytochrome hydrogenase;
hydrogenase [ambiguous]
Class
Oxidoreductases;
Acting on hydrogen as donor;
With a cytochrome as acceptor
BRITE hierarchy
Sysname
hydrogen:ferricytochrome-c3 oxidoreductase
Reaction(IUBMB)
H2 + 2 ferricytochrome c3 = 2 H+ + 2 ferrocytochrome c3 [RN:R04015]
Reaction(KEGG)
Substrate
H2 [CPD:C00282];
ferricytochrome c3 [CPD:C02682]
Product
H+ [CPD:C00080];
ferrocytochrome c3 [CPD:C02684]
Comment
An iron-sulfur protein. Some forms of the enzyme contain nickel ([NiFe]-hydrogenases) and, of these, some contain selenocysteine ([NiFeSe]-hydrogenases). Methylene blue and other acceptors can also be reduced.
History
EC 1.12.2.1 created 1972, modified 2002
Orthology
K00437  [NiFe] hydrogenase large subunit
K18008  [NiFe] hydrogenase small subunit
Genes
GUR: Gura_0544
DVU: DVU1921(hynB-1) DVU1922(hynA-1)
DVL: Dvul_1245 Dvul_1246
DVM: DvMF_0270 DvMF_0271
DVG: Deval_1388 Deval_1389
DDE: Dde_2137 Dde_2138
DDS: Ddes_1038 Ddes_1039
DDN: DND132_3240 DND132_3241
DMA: DMR_15600 DMR_15610
DSA: Desal_1915 Desal_1916
DHY: DESAM_22353(hybC) DESAM_22354(hydA)
DGG: DGI_2261(hydB) DGI_2262(hydA)
DPI: BN4_11411(hynB-1) BN4_12037(hynB)
DRT: Dret_0265(hydB) Dret_0266(hydA)
DSF: UWK_01156
DAT: HRM2_22350(hynB) HRM2_22360(hynA)
 » show all
Taxonomy
Reference
1  [PMID:4364940]
  Authors
Der Vartanian DV, LeGall J.
  Title
A monomolecular electron transfer chain: structure and function of cytochrome C3.
  Journal
Biochim Biophys Acta 346:79-99 (1974)
Reference
2  [PMID:3546297]
  Authors
Higuchi Y, Yasuoka N, Kakudo M, Katsube Y, Yagi T, Inokuchi H.
  Title
Single crystals of hydrogenase from Desulfovibrio vulgaris Miyazaki F.
  Journal
J Biol Chem 262:2823-5 (1987)
  Sequence
Reference
3  [PMID:13741672]
  Authors
RIKLIS E, RITTENBERG D.
  Title
Some observations on the enzyme, hydrogenase.
  Journal
J Biol Chem 236:2526-9 (1961)
Reference
4  [PMID:13745271]
  Authors
SADANA JC, MOREY AV.
  Title
Purification and properties of the hydrogenase of Desulfovibrio desulfuricans.
  Journal
Biochim Biophys Acta 50:153-63 (1961)
DOI:10.1016/0006-3002(61)91072-1
Reference
5  [PMID:7854413]
  Authors
Volbeda A, Charon MH, Piras C, Hatchikian EC, Frey M, Fontecilla-Camps JC.
  Title
Crystal structure of the nickel-iron hydrogenase from Desulfovibrio gigas.
  Journal
Nature 373:580-7 (1995)
DOI:10.1038/373580a0
  Sequence
Reference
6  [PMID:10378275]
  Authors
Garcin E, Vernede X, Hatchikian EC, Volbeda A, Frey M, Fontecilla-Camps JC.
  Title
The crystal structure of a reduced [NiFeSe] hydrogenase provides an image of the activated catalytic center.
  Journal
Structure 7:557-66 (1999)
DOI:10.1016/S0969-2126(99)80072-0
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.12.2.1
IUBMB Enzyme Nomenclature: 1.12.2.1
ExPASy - ENZYME nomenclature database: 1.12.2.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.12.2.1
BRENDA, the Enzyme Database: 1.12.2.1
CAS: 9027-05-8

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