KEGG   ENZYME: 1.12.98.3Help
Entry
EC 1.12.98.3                Enzyme                                 

Name
Methanosarcina-phenazine hydrogenase;
methanophenazine hydrogenase;
methylviologen-reducing hydrogenase
Class
Oxidoreductases;
Acting on hydrogen as donor;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase
Reaction(IUBMB)
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine [RN:R09095]
Reaction(KEGG)
Substrate
H2 [CPD:C00282];
2-(2,3-dihydropentaprenyloxy)phenazine [CPD:C11903]
Product
2-dihydropentaprenyloxyphenazine
Comment
Contains nickel, iron-sulfur clusters and cytochrome b. The enzyme from some sources contains selenocysteine.
History
EC 1.12.98.3 created 2002
Orthology
K14068  methanophenazine hydrogenase, large subunit
K14069  methanophenazine hydrogenase, cytochrome b subunit
K14070  methanophenazine hydrogenase
Genes
GAC: GACE_0715
GAH: GAH_02042
MAC: MA_1141(vhtG) MA_1142(vhtA) MA_1143(vhtC) MA_1146(vhtG) MA_1147(vhtA) MA_1148(vhtC)
MBA: Mbar_A1839 Mbar_A1840 Mbar_A1841 Mbar_A1845 Mbar_A1846 Mbar_A1847
MBY: MSBRM_2559 MSBRM_2560 MSBRM_2561 MSBRM_2565 MSBRM_2566 MSBRM_2567
MBW: MSBRW_2889 MSBRW_2890 MSBRW_2891 MSBRW_2894 MSBRW_2895 MSBRW_2896
MBAR: MSBR2_2533 MSBR2_2534 MSBR2_2535 MSBR2_2539 MSBR2_2540 MSBR2_2541
MBAK: MSBR3_2555 MSBR3_2556 MSBR3_2557 MSBR3_2562 MSBR3_2563 MSBR3_2564
MMA: MM_2169(vhtG) MM_2170(vhtA) MM_2171(vhtC) MM_2175 MM_2176 MM_2177 MM_2312(vhoC) MM_2313(vhoA) MM_2314(vhoG)
MMAZ: MmTuc01_2221 MmTuc01_2222 MmTuc01_2223 MmTuc01_2227 MmTuc01_2228 MmTuc01_2229 MmTuc01_2361
MPD: MCP_2934(vhtG) MCP_2935(vhtA) MCP_2936(vhtC)
MEZ: Mtc_0470(vhtG) Mtc_0471(vhtA) Mtc_0472(vhtC)
RCI: RCIX880(vhtG) RCIX882(vhtA) RCIX885(vhtC)
 » show all
Taxonomy
Reference
1  [PMID:9555882]
  Authors
Abken HJ, Tietze M, Brodersen J, Baumer S, Beifuss U, Deppenmeier U.
  Title
Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei Go1.
  Journal
J Bacteriol 180:2027-32 (1998)
Reference
2  [PMID:10471795]
  Authors
Deppenmeier U, Lienard T, Gottschalk G.
  Title
Novel reactions involved in energy conservation by methanogenic archaea.
  Journal
FEBS Lett 457:291-7 (1999)
DOI:10.1016/S0014-5793(99)01026-1
Reference
3  [PMID:10941105]
  Authors
Beifuss U, Tietze M, Baumer S, Deppenmeier U.
  Title
Methanophenazine: Structure, Total Synthesis, and Function of a New Cofactor from Methanogenic Archaea This work was supported by the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich 416; grants De 488/6-1 and De 488/4-2) and the Fonds der Chemischen Industrie. We are grateful to Drs. J. Paust and H. Jaedicke (BASF AG, Ludwigshafen) and Dr. R. K. Muller (Hoffmann-La Roche Ltd., Basel) for generously providing chemicals.
  Journal
Angew Chem Int Ed Engl 39:2470-2472 (2000)
DOI:10.1002/1521-3773(20000717)39:14<2470::AID-ANIE2470>3.0.CO;2-R
Other DBs
ExplorEnz - The Enzyme Database: 1.12.98.3
IUBMB Enzyme Nomenclature: 1.12.98.3
ExPASy - ENZYME nomenclature database: 1.12.98.3
BRENDA, the Enzyme Database: 1.12.98.3
CAS: 9027-05-8

DBGET integrated database retrieval system