KEGG   ENZYME: 1.12.98.4Help
Entry
EC 1.12.98.4                Enzyme                                 

Name
sulfhydrogenase;
sulfur reductase
Class
Oxidoreductases;
Acting on hydrogen as donor;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
H2:polysulfide oxidoreductase
Reaction(IUBMB)
H2 + (sulfide)n = hydrogen sulfide + (sulfide)n-1 [RN:R10390]
Reaction(KEGG)
Substrate
H2 [CPD:C00282];
(sulfide)n [CPD:C19692]
Product
hydrogen sulfide [CPD:C00283];
(sulfide)n-1
Comment
An iron-sulfur protein. The enzyme from the hyperthermophilic archaeon Pyrococcus furiosus is part of two heterotetrameric complexes where the beta and gamma subunits function as sulfur reductase and the alpha and delta subunits function as hydrogenases (EC 1.12.1.3, hydrogen dehydrogenase [NADP+] and EC 1.12.1.4, hydrogen dehydrogenase [NAD(P)+], respectively). Sulfur can also be used as substrate, but since it is insoluble in aqueous solution and polysulfide is generated abiotically by the reaction of hydrogen sulfide and sulfur, polysulfide is believed to be the true substrate [2].
History
EC 1.12.98.4 created 1992 as EC 1.97.1.3, transferred 2013 to EC 1.12.98.4
Pathway
ec00920  Sulfur metabolism
Orthology
K17995  sulfhydrogenase subunit gamma (sulfur reductase)
K17996  sulfhydrogenase subunit beta (sulfur reductase)
Genes
PHO: PH1290(PH1290) PH1291(PH1291)
PAB: PAB0638(hydB-2) PAB0639(hydG-2) PAB1784 PAB1785
PFU: PF0891 PF0892 PF1329 PF1330
PFI: PFC_03665 PFC_03670 PFC_05860 PFC_05865
PYN: PNA2_1554 PNA2_1555 PNA2_1667 PNA2_1668
PYA: PYCH_00020 PYCH_00030 PYCH_08390 PYCH_08400
PYS: Py04_0890 Py04_0891 Py04_1131 Py04_1132
TKO: TK2071 TK2072
TON: TON_0054 TON_0055 TON_0536 TON_0537
TSI: TSIB_0282 TSIB_0283 TSIB_1520 TSIB_1521
 » show all
Taxonomy
Reference
1
  Authors
Zophel, A., Kennedy, M.C., Beinert, H. and Kroneck, P.M.H.
  Title
Investigations on microbial sulfur respiration. 1. Activation and reduction of elemental sulfur in several strains of Eubacteria.
  Journal
Arch Microbiol 150:72-77 (1988)
Reference
2  [PMID:8389482]
  Authors
Ma K, Schicho RN, Kelly RM, Adams MW
  Title
Hydrogenase of the hyperthermophile Pyrococcus furiosus is an elemental sulfur reductase or sulfhydrogenase: evidence for a sulfur-reducing hydrogenase ancestor.
  Journal
Proc Natl Acad Sci U S A 90:5341-4 (1993)
DOI:10.1073/pnas.90.11.5341
  Sequence
Reference
3
  Authors
Ma, K., Zhou, Z.H. and Adams, M.W.
  Title
Hydrogen production from pyruvate by enzymes purified from the hyperthermophilic archaeon, Pyrococcus furiosus: A key role for NADPH.
  Journal
FEMS Microbiol Lett 122:245-250 (1994)
Reference
4  [PMID:10714990]
  Authors
Ma K, Weiss R, Adams MW
  Title
Characterization of hydrogenase II from the hyperthermophilic archaeon Pyrococcus furiosus and assessment of its role in sulfur reduction.
  Journal
J Bacteriol 182:1864-71 (2000)
DOI:10.1128/JB.182.7.1864-1871.2000
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.12.98.4
IUBMB Enzyme Nomenclature: 1.12.98.4
ExPASy - ENZYME nomenclature database: 1.12.98.4
BRENDA, the Enzyme Database: 1.12.98.4

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