KEGG   ENZYME: 1.13.11.10Help
Entry
EC 1.13.11.10               Enzyme                                 

Name
7,8-dihydroxykynurenate 8,8a-dioxygenase;
7,8-dihydroxykynurenate oxygenase;
7,8-dihydroxykynurenate 8,8alpha-dioxygenase;
7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (ring-opening)
Reaction(IUBMB)
7,8-dihydroxykynurenate + O2 = 5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate [RN:R03253]
Reaction(KEGG)
Substrate
7,8-dihydroxykynurenate [CPD:C01111];
O2 [CPD:C00007]
Product
5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate [CPD:C05641]
Comment
Requires Fe2+.
History
EC 1.13.11.10 created 1965 as EC 1.13.1.10, transferred 1972 to EC 1.13.11.10
Pathway
ec00380  Tryptophan metabolism
Reference
1
  Authors
Kuno, S., Tashiro, M., Taniuchi, H., Horibata, K., Hayaishi, O., Seno, S., Tokuyama, T. and Sakan, T.
  Title
Enzymatic degradation of kynurenic acid.
  Journal
Fed Proc 20:3 (1961)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.10
IUBMB Enzyme Nomenclature: 1.13.11.10
ExPASy - ENZYME nomenclature database: 1.13.11.10
BRENDA, the Enzyme Database: 1.13.11.10
CAS: 9029-58-7

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