KEGG   ENZYME: 1.13.11.19Help
Entry
EC 1.13.11.19               Enzyme                                 

Name
cysteamine dioxygenase;
persulfurase;
cysteamine oxygenase;
cysteamine:oxygen oxidoreductase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
2-aminoethanethiol:oxygen oxidoreductase
Reaction(IUBMB)
2-aminoethanethiol + O2 = hypotaurine [RN:R02467]
Reaction(KEGG)
Substrate
2-aminoethanethiol [CPD:C01678];
O2 [CPD:C00007]
Product
hypotaurine [CPD:C00519]
Comment
A non-heme iron protein that is involved in the biosynthesis of taurine. Requires catalytic amounts of a cofactor-like compound, such as sulfur, sufide, selenium or methylene blue for maximal activity. 3-Aminopropanethiol (homocysteamine) and 2-mercaptoethanol can also act as substrates, but glutathione, cysteine, and cysteine ethyl- and methyl esters are not good substrates [1,3].
History
EC 1.13.11.19 created 1972, modified 2006
Pathway
ec00430  Taurine and hypotaurine metabolism
ec01100  Metabolic pathways
Orthology
K10712  cysteamine dioxygenase
Genes
HSA: 84890(ADO)
PTR: 748534(ADO)
PPS: 100991144(ADO)
GGO: 101136773(ADO)
PON: 100452250(ADO)
NLE: 100602024(ADO)
MCC: 698259(ADO)
MCF: 102116205(ADO)
CSAB: 103216129(ADO)
RRO: 104655645(ADO)
RBB: 108533154(ADO)
CJC: 100405905(ADO)
SBQ: 101033067(ADO)
MMU: 211488(Ado)
RNO: 309732(Ado)
CGE: 103160118
NGI: 103737475(Ado)
HGL: 101713027(Ado)
CCAN: 109676110 109700462(Ado)
OCU: 103351357(ADO)
TUP: 102479881(ADO)
CFA: 489003(ADO) 610687
AML: 100479309(ADO)
UMR: 103667994(ADO)
ORO: 101372697(ADO) 101378375
FCA: 101082264(ADO)
BTA: 100297937(ADO)
BOM: 102276184(ADO)
PHD: 102324569(ADO)
CHX: 102174627(ADO)
OAS: 101121567(ADO)
SSC: 100153304(ADO)
CDK: 105093860(ADO)
BACU: 103000138(ADO)
LVE: 103087408(ADO)
OOR: 101273659(ADO)
ECB: 100147027(ADO)
EPZ: 103548677(ADO)
EAI: 106826174(ADO)
MYB: 102256478(ADO)
MYD: 102761687(ADO)
HAI: 109380639(ADO)
PALE: 102883157(ADO)
LAV: 100671174(ADO)
TMU: 101342381
MDO: 100017045(ADO)
OAA: 100079506(ADO)
GGA: 107053634(ADO)
CJO: 107315686(ADO)
FAB: 101819629(ADO)
PHI: 102107641(ADO)
PMAJ: 107207126(ADO)
AMJ: 102567096(ADO)
CPIC: 101931118(ADO)
PVT: 110078729(ADO)
GJA: 107112662(ADO)
XLA: 108697364(ado.S) 494774(ado.L)
XTR: 100485786(ado)
NPR: 108804787(ADO)
DRE: 406474(adob)
IPU: 108270460 108273399(ado)
LCO: 104924320(ado) 104935916
NCC: 104946380(ado) 104965501
PRET: 103477378 103482206(ado)
NFU: 107373913 107396840(ado)
KMR: 108245155(ado) 108246615
CSEM: 103381678(ado)
SDU: 111224250 111237081(ado)
HCQ: 109510061 109529318(ado)
BPEC: 110153143 110154204(ado)
ELS: 105010537 105026306(ado)
SFM: 108932788 108939586(ado)
CMK: 103181026(ado)
SPU: 582096
APLC: 110977046
SKO: 100367728
DME: Dmel_CG7550(CG7550)
DSI: Dsimw501_GD13021(Dsim_GD13021)
MDE: 101894845
AAG: 5571697
AME: 724666
BIM: 100746274
BTER: 100643470
SOC: 105198180
AEC: 105151949
ACEP: 105625013
HST: 105183995
DQU: 106746200
LHU: 105679866
PGC: 109860287
PCF: 106791493
NVI: 100123227
MDL: 103573176
TCA: 663771
DPA: 109542797
NVL: 108562236
BMOR: 101739372
PMAC: 106720496
PRAP: 110997264
HAW: 110373588
PXY: 105383456
API: 100163420
DNX: 107164682
CLEC: 106666739
ZNE: 110834893
FCD: 110851131
TUT: 107368105
TSP: Tsp_04201
CRG: 105321217
MYI: 110464677
OBI: 106869111
LAK: 106153676
SHX: MS3_08185
EGL: EGR_05074
EPA: 110250879
ADF: 107334487
HMG: 100208908
AQU: 100637030
LJA: Lj0g3v0019699.1(Lj0g3v0019699.1) Lj0g3v0102909.1(Lj0g3v0102909.1) Lj0g3v0102909.2(Lj0g3v0102909.2) Lj0g3v0257439.1(Lj0g3v0257439.1) Lj0g3v0257439.2(Lj0g3v0257439.2) Lj0g3v0317119.1(Lj0g3v0317119.1) Lj1g3v0250220.1(Lj1g3v0250220.1) Lj1g3v2953570.1(Lj1g3v2953570.1) Lj1g3v3976010.1(Lj1g3v3976010.1) Lj2g3v1034740.1(Lj2g3v1034740.1)
DOSA: Os01t0185500-00(Os01g0185500) Os02t0320000-00(Os02g0320000) Os03t0654700-01(Os03g0654700) Os03t0655100-00(Os03g0655100) Os04t0151900-01(Os04g0151900) Os05t0592300-01(Os05g0592300) Os08t0133000-01(Os08g0133000) Os08t0133700-00(Os08g0133700) Os08t0480400-01(Os08g0480400) Os09t0316000-01(Os09g0316000) Os09t0471000-01(Os09g0471000) Os12t0623600-01(Os12g0623600)
ATS: 109753559(LOC109753559) 109764407(LOC109764407) 109764417(LOC109764417) 109764422 109764433(LOC109764433) 109774669(LOC109774669) 109780402(LOC109780402) 109780403(LOC109780403) 109780421(LOC109780421) 109787301(LOC109787301)
APRO: F751_5685
SMIN: v1.2.010395.t1(symbB.v1.2.010395.t1) v1.2.011315.t1(symbB.v1.2.011315.t1)
SPAR: SPRG_04480
GLJ: GKIL_3765
 » show all
Taxonomy
Reference
1  [PMID:5912113]
  Authors
Cavallini D, De Marco C, Scandurra R, Dupre S, Graziani MT.
  Title
The enzymatic oxidation of cysteamine to hypotaurine. Purification and properties of the enzyme.
  Journal
J Biol Chem 241:3189-96 (1966)
Reference
2  [PMID:6052430]
  Authors
Wood JL, Cavallini D.
  Title
Enzymic oxidation of cysteamine to hypotaurine in the absence of a cofactor.
  Journal
Arch Biochem Biophys 119:368-72 (1967)
DOI:10.1016/0003-9861(67)90467-5
Reference
3  [PMID:1157952]
  Authors
Cavallini D, Federici G, Ricci G, Dupre S, Antonucci A.
  Title
The specificity of cysteamine oxygenase.
  Journal
FEBS Lett 56:348-51 (1975)
DOI:10.1016/0014-5793(75)81124-0
Reference
4  [PMID:3657558]
  Authors
Richerson RB, Ziegler DM.
  Title
Cysteamine dioxygenase.
  Journal
Methods Enzymol 143:410-5 (1987)
DOI:10.1016/0076-6879(87)43071-1
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.19
IUBMB Enzyme Nomenclature: 1.13.11.19
ExPASy - ENZYME nomenclature database: 1.13.11.19
BRENDA, the Enzyme Database: 1.13.11.19
CAS: 9033-41-4

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