KEGG   ENZYME: 1.13.11.24Help
Entry
EC 1.13.11.24               Enzyme                                 

Name
quercetin 2,3-dioxygenase;
quercetinase;
flavonol 2,4-oxygenase;
quercetin:oxygen 2,3-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
quercetin:oxygen 2,3-oxidoreductase (ring-opening)
Reaction(IUBMB)
quercetin + O2 = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H+ [RN:R02156]
Reaction(KEGG)
Substrate
quercetin [CPD:C00389];
O2 [CPD:C00007]
Product
2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate [CPD:C04524];
CO [CPD:C00237];
H+ [CPD:C00080]
Comment
The enzyme from Aspergillus sp. is a copper protein whereas that from Bacillus subtilis contains iron. Quercetin is a flavonol (5,7,3',4'-tetrahydroxyflavonol).
History
EC 1.13.11.24 created 1972
Orthology
K07155  quercetin 2,3-dioxygenase
Genes
HEL: HELO_2888(qdoI)
AGE: AA314_07274
MBD: MEBOL_002154
CFUS: CYFUS_004771
YAN: AYJ57_22325
BSU: BSU39980(qodI)
BSR: I33_4162
BSL: A7A1_2406
BSH: BSU6051_39980(qodI)
BSY: I653_19620
BSUT: BSUB_04240(qdoI)
BSUL: BSUA_04240(qdoI)
BSUS: Q433_22030
BSS: BSUW23_19920(qodI)
BST: GYO_4398
BSO: BSNT_10685(yxaG)
BSQ: B657_39980(qodI)
BSX: C663_3913
BPU: BPUM_0236
BPUM: BW16_01535
BPUS: UP12_01510
BJS: MY9_4128
BACW: QR42_01470
BACY: QF06_18445
BACL: BS34A_43240(qodI)
BALM: BsLM_4042
BEO: BEH_14305
PMS: KNP414_04888(qdoI)
PMW: B2K_22250
SRW: TUE45_00589(qdoI_1)
STRD: NI25_02960
ACH: Achl_0454
ABAS: ACPOL_2694
SLI: Slin_0109
 » show all
Taxonomy
Reference
1  [PMID:5579942]
  Authors
Oka T, Simpson FJ.
  Title
Quercetinase, a dioxygenase containing copper.
  Journal
Biochem Biophys Res Commun 43:1-5 (1971)
DOI:10.1016/S0006-291X(71)80076-1
Reference
2  [PMID:12486225]
  Authors
Steiner RA, Kalk KH, Dijkstra BW.
  Title
Anaerobic enzyme.substrate structures provide insight into the reaction mechanism of the copper-dependent quercetin 2,3-dioxygenase.
  Journal
Proc Natl Acad Sci U S A 99:16625-30 (2002)
DOI:10.1073/pnas.262506299
Reference
3  [PMID:14741339]
  Authors
Bowater L, Fairhurst SA, Just VJ, Bornemann S.
  Title
Bacillus subtilis YxaG is a novel Fe-containing quercetin 2,3-dioxygenase.
  Journal
FEBS Lett 557:45-8 (2004)
DOI:10.1016/S0014-5793(03)01439-X
  Sequence
[bsu:BSU39980]
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.24
IUBMB Enzyme Nomenclature: 1.13.11.24
ExPASy - ENZYME nomenclature database: 1.13.11.24
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.24
BRENDA, the Enzyme Database: 1.13.11.24
CAS: 9075-67-6

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