KEGG ENZYME: 1.13.11.24

ENZYME: 1.13.11.24

Entry

EC 1.13.11.24 Enzyme

Name

quercetin 2,3-dioxygenase;
quercetinase;
flavonol 2,4-oxygenase;
quercetin:oxygen 2,3-oxidoreductase (decyclizing)

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen

Sysname

quercetin:oxygen 2,3-oxidoreductase (ring-opening)

Reaction(IUBMB)

quercetin + O2 = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H+ [RN:R02156]

Reaction(KEGG)

R02156

Substrate

quercetin [CPD:C00389];
O2 [CPD:C00007]

Product

2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate [CPD:C04524];
CO [CPD:C00237];
H+ [CPD:C00080]

Comment

The enzyme from Aspergillus sp. is a copper protein whereas that from Bacillus subtilis contains iron. Quercetin is a flavonol (5,7,3',4'-tetrahydroxyflavonol).

History

EC 1.13.11.24 created 1972

Orthology

K07155

quercetin 2,3-dioxygenase

Genes

HEL:	HELO_2888(qdoI)

AGE:	AA314_07274

MBD:	MEBOL_002154

CFUS:

CYFUS_004771

YAN:	AYJ57_22325

BSU:	BSU39980(qodI)

BSR:

I33_4162

BSL:

A7A1_2406

BSH:	BSU6051_39980(qodI)

BSY:	I653_19620

BSUT:

BSUB_04240(qdoI)

BSUL:

BSUA_04240(qdoI)

BSUS:

Q433_22030

BSS:	BSUW23_19920(qodI)

BST:

GYO_4398

BSO:	BSNT_10685(yxaG)

BSN:	BSn5_10990

BSQ:	B657_39980(qodI)

BSX:

C663_3913

BSP:	U712_20225

BAE:	BATR1942_17965

BPU:

BPUM:

BPUS:

BJS:

BACW:

BACY:

BACL:

BS34A_43240(qodI)

BALM:

BsLM_4042

BEO:

BEH_14305

BGI:	BGM20_14230

BXI:	BK049_06780

BALT:

CFN77_01515

BSAF:

BSL056_01455

BIT:	BIS30_09825

PPQ:	PPSQR21_025760

PMS:	KNP414_04888(qdoI)

PMQ:	PM3016_4292

PMW:

B2K_22250

PBV:	AR543_13310

GPO:	GPOL_c14150

SCT:	SCAT_p0591

SCY:	SCATT_p11500

SCW:	TU94_29700

SAMB:

SAM23877_6512

SRW:	TUE45_00589(qdoI_1)

STSI:

A4E84_34970

STRD:

NI25_02960

SSIA:

A7J05_22290

MVD:	AWU67_00595

ARN:	CGK93_09980

ACH:

Achl_0454

APN:	Asphe3_17030

GAR:	AOZ07_16230

NGV:	CDO52_26120

NOA:	BKM31_16695

AAB:	A4R43_07770

AEY:	CDG81_10395

ABAS:

ACPOL_2694

SLI:

Slin_0109

SPIR:

CWM47_19865

HYM:	N008_18130

» show all

Reference

1 [PMID:5579942]

Authors

Oka T, Simpson FJ.

Title

Quercetinase, a dioxygenase containing copper.

Journal

Biochem Biophys Res Commun 43:1-5 (1971)
DOI:10.1016/S0006-291X(71)80076-1

Reference

2 [PMID:12486225]

Authors

Steiner RA, Kalk KH, Dijkstra BW.

Title

Anaerobic enzyme.substrate structures provide insight into the reaction mechanism of the copper-dependent quercetin 2,3-dioxygenase.

Journal

Proc Natl Acad Sci U S A 99:16625-30 (2002)
DOI:10.1073/pnas.262506299

Reference

3 [PMID:14741339]

Authors

Bowater L, Fairhurst SA, Just VJ, Bornemann S.

Title

Bacillus subtilis YxaG is a novel Fe-containing quercetin 2,3-dioxygenase.

Journal

FEBS Lett 557:45-8 (2004)
DOI:10.1016/S0014-5793(03)01439-X

Sequence

[bsu:BSU39980]

Other DBs

ExplorEnz - The Enzyme Database:

1.13.11.24

IUBMB Enzyme Nomenclature:

1.13.11.24

ExPASy - ENZYME nomenclature database:

1.13.11.24

UM-BBD (Biocatalysis/Biodegradation Database):

1.13.11.24

BRENDA, the Enzyme Database:

1.13.11.24

CAS:

9075-67-6

DBGET integrated database retrieval system