KEGG   ENZYME: 1.13.11.25Help
Entry
EC 1.13.11.25               Enzyme                                 

Name
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase;
steroid 4,5-dioxygenase;
3-alkylcatechol 2,3-dioxygenase;
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (ring-opening)
Reaction(IUBMB)
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate [RN:R04597]
Reaction(KEGG)
Substrate
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione [CPD:C04793];
O2 [CPD:C00007]
Product
3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate [CPD:C04844]
Comment
Requires Fe2+. Also acts on 3-isopropylcatechol and 3-tert-butyl-5-methylcatechol.
History
EC 1.13.11.25 created 1972
Pathway
ec00984  Steroid degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K16049  3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
Genes
PRE: PCA10_13380
PPUT: L483_14230
PPUN: PP4_26930
PVR: PverR02_11720
PPUU: PputUW4_01687
PKC: PKB_4267(hsaC)
PFZ: AV641_10715
PLQ: AA042_19960
PPSY: AOC04_08020
PSET: THL1_1410
PSIL: PMA3_11800
SPL: Spea_2153
SHL: Shal_2124
PHA: PSHAa0900(tesB)
PNG: PNIG_a1084(hsaC)
GPB: HDN1F_27360(bphC1)
RIN: ACS15_4384(hsaC)
REH: H16_B0654(bphC)
CNC: CNE_2c06010(bphC)
CTI: RALTA_B0496(bphC)
BCJ: BCAM1637
BCEN: DM39_6216(hsaC)
BCEO: I35_5498
BCT: GEM_4079
BCED: DM42_6321(hsaC)
BCON: NL30_03995
BTEI: WS51_05820
BPSL: WS57_05915
BMEC: WJ16_26910
BFN: OI25_4609
CTES: O987_07285
NAR: Saro_3647
SWI: Swit_3298
SPHM: G432_04775
SSAN: NX02_14735
SPHB: EP837_03390(hsaC)
MTU: Rv3568c(hsaC)
MTC: MT3673
MRA: MRA_3607(bphC)
MTUR: CFBS_3785(bphC)
MTO: MTCTRI2_3633(bphC)
MTD: UDA_3568c(bphC)
MTN: ERDMAN_3915(bphC)
MTUC: J113_24990
MTUE: J114_19085
MTUL: TBHG_03509
MTUT: HKBT1_3770(bphC)
MTUU: HKBT2_3779(bphC)
MTQ: HKBS1_3782(bphC)
MBO: BQ2027_MB3599C(hsac)
MBB: BCG_3633c(bphC)
MBT: JTY_3634(bphC)
MBM: BCGMEX_3631c(bphC)
MBX: BCGT_3435
MAF: MAF_35810(bphC)
MMIC: RN08_3945
MCE: MCAN_35811(bphC)
MCQ: BN44_110063(hsaC)
MCV: BN43_90069(hsaC)
MCX: BN42_90066(hsaC)
MCZ: BN45_100082(hsaC)
MPA: MAP_0499
MAO: MAP4_3368
MAVI: RC58_16705
MAVU: RE97_16740
MAV: MAV_0593
MAVD: NF84_02665
MAVR: LA63_02730
MAVA: LA64_02740
MIT: OCO_05020
MIA: OCU_05060
MID: MIP_00943
MYO: OEM_05080
MIR: OCQ_05170
MLP: MLM_0737
MUL: MUL_4139(bphC)
MMC: Mmcs_4707
MKM: Mkms_4793
MJL: Mjls_5092
MMI: MMAR_5063(bphC)
MMAE: MMARE11_48780(bphC)
MMM: W7S_02450
MLI: MULP_05321(bphC)
MHAD: B586_04455
MSG: MSMEI_5875(bphC)
MVA: Mvan_5306
MGI: Mflv_1465
MPHL: MPHLCCUG_00493(hsaC_1)
MVQ: MYVA_5216
MTHN: 4412656_04092(hsaC)
MAB: MAB_0585
MABB: MASS_0554
MABO: NF82_02955
MCHE: BB28_02790
MSTE: MSTE_00542(hsaC)
MJD: JDM601_3853(bphC)
MTER: 4434518_03728(bphC)
ASD: AS9A_0926
NFA: NFA_4720
NFR: ERS450000_00300(bphC_1) ERS450000_03764(hsaC_1)
NNO: NONO_c05030(hsaC1)
RHA: RHA1_ro04541(hsaC)
RER: RER_07570
REY: O5Y_03680
ROP: ROP_44560
RRT: 4535765_00584(hsaC_1) 4535765_01490(hsaC_3)
GBR: Gbro_0921
GPO: GPOL_c41080(hsaC)
GOR: KTR9_0821(hsaC)
TPR: Tpau_3843
SALU: DC74_7447
SALL: SAZ_38440
SLX: SLAV_27440(hsaC)
NDK: I601_3468(hsaC_2)
PSIM: KR76_14470
AMD: AMED_2524
AMN: RAM_12830
AMM: AMES_2496
AMZ: B737_2497
AOI: AORI_2486(bphC)
AJA: AJAP_26395(hsaC)
KAL: KALB_5122
ALL: CRK59592
SAQ: Sare_2877
 » show all
Taxonomy
Reference
1  [PMID:5908121]
  Authors
Gibson DT, Wang KC, Sih CJ, Whitlock H Jr.
  Title
Mechanisms of steroid oxidation by microorganisms. IX. On the mechanism of ring A cleavage in the degradation of 9,10-seco steroids by microorganisms.
  Journal
J Biol Chem 241:551-9 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.25
IUBMB Enzyme Nomenclature: 1.13.11.25
ExPASy - ENZYME nomenclature database: 1.13.11.25
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.25
BRENDA, the Enzyme Database: 1.13.11.25
CAS: 37256-63-6

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