KEGG   ENZYME: 1.13.11.38Help
Entry
EC 1.13.11.38               Enzyme                                 

Name
1-hydroxy-2-naphthoate 1,2-dioxygenase;
1-hydroxy-2-naphthoate dioxygenase;
1-hydroxy-2-naphthoate-degrading enzyme;
1-hydroxy-2-naphthoic acid dioxygenase;
1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (ring-opening)
Reaction(IUBMB)
1-hydroxy-2-naphthoate + O2 = (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate [RN:R07657]
Reaction(KEGG)
R07657;
(other) R03466
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Substrate
1-hydroxy-2-naphthoate [CPD:C03203];
O2 [CPD:C00007]
Product
(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate [CPD:C16149]
Comment
Requires Fe2+. Involved, with EC 4.1.2.34 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase, in the metabolism of phenanthrene in bacteria.
History
EC 1.13.11.38 created 1989
Pathway
ec00624  Polycyclic aromatic hydrocarbon degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K11948  1-hydroxy-2-naphthoate dioxygenase
Genes
MIT: OCO_14840
MIA: OCU_15280
MMC: Mmcs_1628
MKM: Mkms_1654
MJL: Mjls_1601 Mjls_4204
MYE: AB431_15665
MVA: Mvan_0468
MGI: Mflv_0589
MSP: Mspyr1_01470
MRH: MycrhN_3148
 » show all
Taxonomy
Reference
1  [PMID:6833175]
  Authors
Barnsley EA.
  Title
Phthalate pathway of phenanthrene metabolism: formation of 2'-carboxybenzalpyruvate.
  Journal
J Bacteriol 154:113-7 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.38
IUBMB Enzyme Nomenclature: 1.13.11.38
ExPASy - ENZYME nomenclature database: 1.13.11.38
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.38
BRENDA, the Enzyme Database: 1.13.11.38
CAS: 85941-64-6

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