KEGG   ENZYME: 1.13.11.4Help
Entry
EC 1.13.11.4                Enzyme                                 

Name
gentisate 1,2-dioxygenase;
gentisate oxygenase;
2,5-dihydroxybenzoate dioxygenase;
gentisate dioxygenase;
gentisic acid oxidase;
gentisate:oxygen 1,2-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
gentisate:oxygen 1,2-oxidoreductase (ring-opening)
Reaction(IUBMB)
2,5-dihydroxybenzoate + O2 = maleylpyruvate [RN:R02656]
Reaction(KEGG)
Substrate
2,5-dihydroxybenzoate [CPD:C00628];
O2 [CPD:C00007]
Product
maleylpyruvate [CPD:C02167]
Comment
Requires Fe2+.
History
EC 1.13.11.4 created 1961 as EC 1.99.2.4, transferred 1965 to EC 1.13.1.4, transferred 1972 to EC 1.13.11.4
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00450  gentisate 1,2-dioxygenase
Genes
PXB: 103939790
PIC: PICST_55211
SPAA: SPAPADRAFT_146934
SLB: AWJ20_2230
SMP: SMAC_07206
PAN: PODANSg3523
MTM: MYCTH_2120498
MGR: MGG_10213
TMN: UCRPA7_2080 UCRPA7_5977
FGR: FGSG_03604 FGSG_04775
MAW: MAC_06019
MAJ: MAA_06149
CMT: CCM_00823
ANG: ANI_1_114164(An18g01020)
ECE: Z3393
ECS: ECs3030
ECF: ECH74115_3270(gtdA)
ETW: ECSP_3016
EOK: G2583_2681(gtdA)
ECW: EcE24377A_2433(gtdA)
STY: STY2408
STT: t0677
STM: STM2178
SENI: CY43_11715
SPT: SPA0673
SEK: SSPA0632
SEI: SPC_1524
SEC: SCH_2195(gdo)
SEH: SeHA_C2413(gtdA)
SHB: SU5_02770
SEE: SNSL254_A2368(gtdA)
SEW: SeSA_A2417(gtdA)
SEA: SeAg_B2324(gtdA)
SENS: Q786_10810
SED: SeD_A2525(gtdA)
SEG: SG2214
SEL: SPUL_0711
SET: SEN2171
SENA: AU38_10975
SENO: AU37_10985
SENV: AU39_10985
SENQ: AU40_12285
SENL: IY59_11280
SEEP: I137_03230
SENB: BN855_22670(gdo)
SENE: IA1_10895
SBG: SBG_1990
SBZ: A464_2302
KOX: KOX_25690
KOE: A225_4038
EAE: EAE_23890
EAR: CCG29098
KQV: B8P98_08950(gtdA)
CKO: CKO_00651
CRO: ROD_22661
CBRA: A6J81_00335(gtdA)
CYO: CD187_08410(gtdA)
CAMA: F384_11435
CAF: AL524_11370(gtdA)
CFAR: CI104_16820(gtdA)
CIR: C2U53_26670(gtdA)
CIE: AN232_13130(gtdA)
EBF: D782_1483
SPE: Spro_4624
SMAR: SM39_2829(mhbD)
SMAC: SMDB11_2642(mhbD)
SERA: Ser39006_000210(gtdA)
XDO: XDD1_0583
PRG: RB151_004990(nagI)
PAE: PA2470(gtdA)
PAEV: N297_2541(gtdA)
PAEI: N296_2541(gtdA)
PAU: PA14_32690(gtdA)
PAP: PSPA7_2768(gtdA)
PAG: PLES_28261(gtdA)
PAF: PAM18_2569(gtdA)
PNC: NCGM2_3472(gtdA)
PAEB: NCGM1900_4060(gtdA)
PAEP: PA1S_13290
PAEM: U769_12875
PAEL: T223_14495
PAEU: BN889_02697(gtdA)
PAEG: AI22_20625
PAEC: M802_2538(gtdA)
PEN: PSEEN2593(mhbD)
PSEM: TO66_18355
PSIL: PMA3_24445
LLO: LLO_3229
LFA: LFA_2294
OCE: GU3_03010
PSE: NH8B_2048
RSO: RSc1087(nagI) RSc1825
RSN: RSPO_c02277(nagI)
REH: H16_B0873(h16_B0873)
BCN: Bcen_4221
BCJ: BCAM1271(mhbD)
BCEN: DM39_3730(gtdA) DM39_4077(gtdA) DM39_4231(gtdA) DM39_5107
BCEO: I35_5120(mhbD)
BMU: Bmul_4442
BMK: DM80_1420(gtdA) DM80_1452 DM80_3607(gtdA)
BMUL: NP80_4172(gtdA)
BCT: GEM_4472
BCED: DM42_3821(gtdA)
BCON: NL30_06245
BTEI: WS51_04040
BPSL: WS57_07675
BMEC: WJ16_24835
BGO: BM43_4137(gtdA)
BXB: DR64_317(gtdA)
BFN: OI25_3044(gtdA)
PSPU: NA29_07590
BAV: BAV1782(nagI)
BHZ: ACR54_02468(nagI_2)
AXY: AXYL_00452(gtdA1) AXYL_05891(gtdA2)
AFQ: AFA_00275
AAV: Aave_0146
VEI: Veis_4214
DAC: Daci_3702
VAM: C4F17_17020(gtdA)
CTES: O987_16725
RTA: Rta_17930
LIM: L103DPR2_00110(nagI)
LIH: L63ED372_01175(nagI)
HYB: Q5W_24085
JSV: CNX70_17170(gtdA)
EBA: ebA1373(nagI) ebA5613(nagI)
AZO: azo2420(nagI)
AOA: dqs_2564
TCL: Tchl_1077
SIX: BSY16_5751(gtdA)
ARA: Arad_7203
BRA: BRADO0683
BRS: S23_07020
AOL: S58_69560
BRAD: BF49_3520
BRK: CWS35_03710(gtdA)
BOT: CIT37_14255(gtdA)
OCA: OCAR_4378
RBM: TEF_20875
CAK: Caul_5250
SIL: SPO3690(gtdA-1) SPOA0115(gtdA-2)
JAN: Jann_2910
PDE: Pden_0167
PGD: Gal_04156
HBA: Hbal_2640
SAL: Sala_1387
SPHP: LH20_08405
SMAZ: LH19_12405
SPHI: TS85_01610
SSY: SLG_11270
SHYD: CJD35_07950(gtdA)
BLAS: BSY18_3950(gtdA)
ALI: AZOLI_p20646(gtdA)
BTW: BF38_4193
BACO: OXB_0839
BEO: BEH_11945
BKW: BkAM31D_23550(nagI_4)
ANM: GFC28_3621(gtdA-2) GFC28_3627
ANL: GFC29_1806 GFC29_1812(gtdA-2)
AAD: TC41_1829
BTS: Btus_2324
SIV: SSIL_3716
CGL: NCgl2920(Cgl3023)
CGB: cg3351(nagI)
CGU: WA5_2920(NagI)
CGT: cgR_2910
CGM: cgp_3351(nagI)
CGJ: AR0_14640
CEF: CE2860
ROP: ROP_15440
RFA: A3L23_05008(nagI)
SHY: SHJG_0194
SALS: SLNWT_4230
SMAL: SMALA_7797
MTS: MTES_3608
ART: Arth_2052
AAU: AAur_0331(gtdA)
CFL: Cfla_0280
CFI: Celf_2995
AOI: AORI_6217
PSEE: FRP1_17645
SESP: BN6_40620
CWO: Cwoe_2813
FIN: KQS_01645
HVO: HVO_A0090(gdoA)
 » show all
Taxonomy
Reference
1
  Authors
Hayaishi, O.
  Title
Direct oxygenation by O2, oxygenases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 353-371.
Reference
2
  Authors
Sugiyama, S., Yano, K., Komagata, K. and Arima, K.
  Title
Metabolites of aromatic compounds by microbes. Part VII. Gentisic acid oxidase.
  Journal
Bull Agric Chem Soc Jpn 24:243-248 (1960)
Reference
3
  Authors
Sugiyama, S., Yano, K. and Arima, K.
  Title
Metabolites of aromatic compounds by microbes. Part VII. Further studies of gentisic acid oxidase.
  Journal
Bull Agric Chem Soc Jpn 24:249-254 (1960)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.4
IUBMB Enzyme Nomenclature: 1.13.11.4
ExPASy - ENZYME nomenclature database: 1.13.11.4
BRENDA, the Enzyme Database: 1.13.11.4
CAS: 9029-48-5

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