Entry |
|
Name |
4-hydroxymandelate synthase;
4-hydroxyphenylpyruvate dioxygenase II
|
Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
 |
Sysname |
(S)-4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)
|
Reaction(IUBMB) |
4-hydroxyphenylpyruvate + O2 = (S)-4-hydroxymandelate + CO2 [RN: R06632]
|
Reaction(KEGG) |
|
Substrate |
|
Product |
|
Comment |
Requires Fe2+. Involved in the biosynthesis of the vancomycin group of glycopeptide antibiotics.
|
History |
EC 1.13.11.46 created 2001
|
Pathway |
ec01055 | Biosynthesis of vancomycin group antibiotics |
ec01130 | Biosynthesis of antibiotics |
|
Orthology |
K16421 | 4-hydroxymandelate synthase |
|
Genes |
» show all
 |
Reference |
|
Authors |
Hubbard BK, Thomas MG, Walsh CT |
Title |
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics. |
Journal |
|
Sequence |
|
Reference |
2 |
Authors |
Choroba, O.W., Williams, D.H. and Spencer, J.B. |
Title |
Biosynthesis of the vancomycin group of antibiotics: involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine. |
Journal |
J Am Chem Soc 122:5389-5390 (2000) |
Other DBs |
|