KEGG   ENZYME: 1.13.11.46Help
Entry
EC 1.13.11.46               Enzyme                                 

Name
4-hydroxymandelate synthase;
4-hydroxyphenylpyruvate dioxygenase II
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
(S)-4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)
Reaction(IUBMB)
4-hydroxyphenylpyruvate + O2 = (S)-4-hydroxymandelate + CO2 [RN:R06632]
Reaction(KEGG)
R06632;
(other) R05778
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Substrate
4-hydroxyphenylpyruvate [CPD:C01179];
O2 [CPD:C00007]
Product
(S)-4-hydroxymandelate [CPD:C03198];
CO2 [CPD:C00011]
Comment
Requires Fe2+. Involved in the biosynthesis of the vancomycin group of glycopeptide antibiotics.
History
EC 1.13.11.46 created 2001
Pathway
ec00261  Monobactam biosynthesis
ec01055  Biosynthesis of vancomycin group antibiotics
ec01130  Biosynthesis of antibiotics
Orthology
K16421  4-hydroxymandelate synthase
Genes
MSD: MYSTI_03600
AGE: AA314_04078
NTP: CRH09_30890(hppD)
SCO: SCO3229(SCE63.04)
SVL: Strvi_8789
SBH: SBI_01126
SRC: M271_09160 M271_27680
SALU: DC74_563
SALL: SAZ_03310
SLV: SLIV_21545
STRE: GZL_08687
SLAU: SLA_6884
KFL: Kfla_6066
SRO: Sros_6970
AOI: AORI_1495(hppD)
AMI: Amir_4590
KAL: KALB_6132
ACTI: UA75_15380
ACAD: UA74_14810
ACTA: C1701_23410(hppD)
SAQ: Sare_2673
MIL: ML5_4909
CAI: Caci_3256
HAU: Haur_1888
 » show all
Taxonomy
Reference
1  [PMID:11137816]
  Authors
Hubbard BK, Thomas MG, Walsh CT
  Title
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.
  Journal
Chem Biol 7:931-42 (2000)
DOI:10.1016/S1074-5521(00)00043-0
  Sequence
Reference
2
  Authors
Choroba, O.W., Williams, D.H. and Spencer, J.B.
  Title
Biosynthesis of the vancomycin group of antibiotics: involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine.
  Journal
J Am Chem Soc 122:5389-5390 (2000)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.46
IUBMB Enzyme Nomenclature: 1.13.11.46
ExPASy - ENZYME nomenclature database: 1.13.11.46
BRENDA, the Enzyme Database: 1.13.11.46
CAS: 280566-04-3

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