KEGG ENZYME: 1.13.11.46

ENZYME: 1.13.11.46

Entry

EC 1.13.11.46 Enzyme

Name

4-hydroxymandelate synthase;
4-hydroxyphenylpyruvate dioxygenase II

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen

Sysname

(S)-4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)

Reaction(IUBMB)

4-hydroxyphenylpyruvate + O2 = (S)-4-hydroxymandelate + CO2 [RN:R06632]

Reaction(KEGG)

R06632;
(other) R05778

Substrate

4-hydroxyphenylpyruvate [CPD:C01179];
O2 [CPD:C00007]

Product

(S)-4-hydroxymandelate [CPD:C03198];
CO2 [CPD:C00011]

Comment

Requires Fe2+. Involved in the biosynthesis of the vancomycin group of glycopeptide antibiotics.

History

EC 1.13.11.46 created 2001

Pathway

ec00261

Monobactam biosynthesis

ec01055

Biosynthesis of vancomycin group antibiotics

ec01130

Biosynthesis of antibiotics

Orthology

K16421

4-hydroxymandelate synthase

Genes

MSD:	MYSTI_03600

AGE:	AA314_04078

NTP:	CRH09_30890(hppD)

SCO:	SCO3229(SCE63.04)

SVL:	Strvi_8789

SBH:

SBI_01126

SRC:	M271_09160 M271_27680

SALU:

DC74_563

SALL:

SAZ_03310

SLV:	SLIV_21545

SVT:	SVTN_32165 SVTN_32295

STRE:

GZL_08687

SLC:	SL103_26560

STRC:

AA958_31850

SAMB:

SAM23877_5652

SRW:	TUE45_06938

SPAV:

Spa2297_02915 Spa2297_26610 Spa2297_32985

STSI:

A4E84_04200 A4E84_32820

SNR:	SNOUR_39385

SPLU:

LK06_002715 LK06_031630

SSIA:

A7J05_04105

SLAU:

SLA_6884

STRO:

STRMOE7_29130

SFK:	KY5_6265c KY5_6719 KY5_7437c

KSK:	KSE_65080 KSE_67340

KAU:	B6264_28345

KIT:	CFP65_1222

KFL:

Kfla_6066

SRO:

Sros_6970

NOA:	BKM31_54205

FRA:	Francci3_2454

AOI:	AORI_1495(hppD)

AJA:	AJAP_32040

AMYB:

BKN51_28930 BKN51_41520

AMI:

KAL:

ACTI:

ACAD:

ACTA:

C1701_23410(hppD)

STP:	Strop_2490 Strop_2727

SAQ:

Sare_2673

MAU:	Micau_3482

MIL:

ML5_4909

MICB:

MicB006_2537

VMA:	VAB18032_22230

CAI:

Caci_3256

HAU:

Haur_1888

» show all

Reference

1 [PMID:11137816]

Authors

Hubbard BK, Thomas MG, Walsh CT

Title

Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.

Journal

Chem Biol 7:931-42 (2000)
DOI:10.1016/S1074-5521(00)00043-0

Sequence

[ag:CAA11761]

Reference

Authors

Choroba, O.W., Williams, D.H. and Spencer, J.B.

Title

Biosynthesis of the vancomycin group of antibiotics: involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine.

Journal

J Am Chem Soc 122:5389-5390 (2000)

Other DBs

ExplorEnz - The Enzyme Database:

1.13.11.46

IUBMB Enzyme Nomenclature:

1.13.11.46

ExPASy - ENZYME nomenclature database:

1.13.11.46

BRENDA, the Enzyme Database:

1.13.11.46

CAS:	280566-04-3

DBGET integrated database retrieval system