KEGG   ENZYME: 1.13.11.54Help
Entry
EC 1.13.11.54               Enzyme                                 

Name
acireductone dioxygenase [iron(II)-requiring];
ARD';
2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase (ambiguous);
acireductone dioxygenase (ambiguous);
E-2';
E-3 dioxygenase;
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one:oxygen oxidoreductase (formate-forming)
Reaction(IUBMB)
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-(methylsulfanyl)-2-oxobutanoate + formate [RN:R07364]
Reaction(KEGG)
Substrate
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one [CPD:C15606];
O2 [CPD:C00007]
Product
4-(methylsulfanyl)-2-oxobutanoate [CPD:C01180];
formate [CPD:C00058]
Comment
Requires iron(II). If Ni2+ is bound instead of iron(II), the reaction catalysed by EC 1.13.11.53, acireductone dioxygenase (Ni2+-requiring), occurs instead. The enzyme from the bacterium Klebsiella oxytoca (formerly Klebsiella pneumoniae) ATCC strain 8724 is involved in the methionine salvage pathway.
History
EC 1.13.11.54 created 2006
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K08967  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Genes
HSA: 55256(ADI1)
PTR: 743384(ADI1)
PPS: 100973573(ADI1)
GGO: 101127803(ADI1)
PON: 100451787(ADI1)
NLE: 100603415(ADI1)
MCC: 722050(ADI1)
MCF: 102141197(ADI1)
CSAB: 103220917(ADI1)
RRO: 104658017(ADI1)
RBB: 108520801(ADI1)
CJC: 100385518(ADI1)
SBQ: 101028666(ADI1)
MMU: 104923(Adi1)
RNO: 298934(Adi1)
CGE: 100754671 100765075(Adi1)
NGI: 103747650(Adi1)
HGL: 101715211(Adi1)
CCAN: 109681863(Adi1)
OCU: 100345201(ADI1)
TUP: 102502690(ADI1)
CFA: 100855962(ADI1)
AML: 100465706(ADI1)
ORO: 101384523(ADI1)
FCA: 101097719(ADI1)
PTG: 102966913(ADI1)
AJU: 106976610(ADI1)
BTA: 615764(ADI1)
BOM: 102272056(ADI1)
BIU: 109563422(ADI1)
PHD: 102316835(ADI1)
CHX: 102181302(ADI1)
OAS: 101113992(ADI1)
SSC: 100626434(ADI1)
CFR: 102510774(ADI1)
CDK: 105094025(ADI1)
BACU: 103007455 103011047(ADI1)
LVE: 103076213 103090632(ADI1)
OOR: 101276143 101276602(ADI1)
ECB: 100072837(ADI1)
EPZ: 103567840(ADI1)
EAI: 106847502(ADI1)
MYB: 102259900(ADI1)
MYD: 102753209(ADI1)
HAI: 109384710(ADI1)
RSS: 109443095 109458393(ADI1)
PALE: 102895914(ADI1)
LAV: 100660105(ADI1)
TMU: 101355764
MDO: 100032300(ADI1) 103096762
SHR: 100934309(ADI1)
OAA: 100092733(ADI1)
GGA: 421918(ADI1)
MGP: 100547720(ADI1)
CJO: 107312177(ADI1)
APLA: 101798237(ADI1)
ACYG: 106030692(ADI1)
TGU: 100229689(ADI1)
GFR: 102035237(ADI1)
FAB: 101811709(ADI1)
PHI: 102109414(ADI1)
PMAJ: 107201628(ADI1)
CCW: 104685463(ADI1)
FPG: 101922892(ADI1)
FCH: 102050788(ADI1)
CLV: 102096012(ADI1)
EGZ: 104122164(ADI1)
AAM: 106492988(ADI1)
ASN: 102381843(ADI1) 102383574
AMJ: 102560467(ADI1)
PSS: 102449726(ADI1)
CMY: 102939421(ADI1)
CPIC: 101931464(ADI1)
ACS: 100559971(adi1)
PVT: 110073419(ADI1)
PBI: 103061729(ADI1)
GJA: 107122318(ADI1)
XLA: 734860(adi1.L)
XTR: 100494108 448325(adi1)
NPR: 108790276(ADI1)
DRE: 324079(adi1)
SRX: 107753353
SANH: 107684237(adi1)
SGH: 107570259(adi1)
CCAR: 109051629(adi1)
IPU: 108270011(adi1)
AMEX: 103047522(adi1)
TRU: 101080180(adi1)
LCO: 104929301(adi1) 109140909
NCC: 104961009(adi1)
MZE: 101476590(adi1)
OLA: 101172696(adi1)
XMA: 102222168(adi1)
PRET: 103458656(adi1)
NFU: 107391711(adi1)
CSEM: 103376620(adi1)
LCF: 108896096(adi1)
HCQ: 109519816(adi1)
SASA: 100196838(adi1)
ELS: 105015760(adi1)
SFM: 108923054(adi1)
LCM: 102364832(ADI1)
CMK: 103185966(adi1)
CIN: 100183249
SPU: 584367
APLC: 110985779
SKO: 100369535
DME: Dmel_CG32068(Adi1)
DSI: Dsimw501_GD14255(Dsim_GD14255)
AAG: 5565540
AME: 551839
BIM: 100742325
BTER: 100646563
SOC: 105195479
AEC: 105144924
ACEP: 105620871
PBAR: 105430865
HST: 105185016
CFO: 105255839
LHU: 105667885
PGC: 109854245
NVI: 100122447
NVL: 108566942
BMOR: 101740178
PRAP: 111001864
API: 100161243
DNX: 107163946
FCD: 110852368
TUT: 107364243
CEL: CELE_F42F12.4(F42F12.4)
CBR: CBG00142
BMY: Bm1_10660
CRG: 109619887
MYI: 110452000
OBI: 106880043
EPA: 110234388
ADF: 107336900
HMG: 100208060
AQU: 100634313
ATH: AT2G26400(ARD3) AT4G14710(ATARD2) AT4G14716(ARD1) AT5G43850(ARD4)
LJA: Lj1g3v0112720.1(Lj1g3v0112720.1) Lj1g3v0112750.1(Lj1g3v0112750.1) Lj1g3v0112780.1(Lj1g3v0112780.1) Lj3g3v0754950.1(Lj3g3v0754950.1) Lj3g3v0754950.2(Lj3g3v0754950.2) Lj5g3v2045410.1(Lj5g3v2045410.1) Lj5g3v2045460.1(Lj5g3v2045460.1)
VVI: 100232920(SIP) 104879260
SLY: 101255136 101255431(ARD)
HAN: 110915626
DOSA: Os03t0161800-01(Os03g0161800) Os04t0345800-00(Os04g0345800) Os10t0419400-01(Os10g0419400) Os10t0419500-01(Os10g0419500)
ATS: 109732573(LOC109732573) 109763703(LOC109763703)
CRE: CHLREDRAFT_137265(ARD1)
VCN: VOLCADRAFT_106957(adi1)
APRO: F751_6856
SCE: YMR009W(ADI1)
ERC: Ecym_4462
KMX: KLMA_50412(ADI1)
NCS: NCAS_0F00990(NCAS0F00990)
NDI: NDAI_0H01480(NDAI0H01480)
TPF: TPHA_0H02500(TPHA0H02500)
TBL: TBLA_0A04840(TBLA0A04840)
TDL: TDEL_0H03380(TDEL0H03380)
KAF: KAFR_0K00850(KAFR0K00850)
CAL: CAALFM_C111100WA(CaO19.2306)
CAUR: QG37_03647
SLB: AWJ20_4826(ADI1)
NCR: NCU00147
NTE: NEUTE1DRAFT63115(NEUTE1DRAFT_63115)
MGR: MGG_06443
SSCK: SPSK_02752
MAJ: MAA_03647
CMT: CCM_05825
BFU: BCIN_03g05390(Bcadi1)
MBE: MBM_03767
ANG: ANI_1_1156134(An15g00990)
ABE: ARB_04132
TVE: TRV_07169
CNE: CNH03570
CNB: CNBI3200
ABP: AGABI1DRAFT116763(AGABI1DRAFT_116763)
ABV: AGABI2DRAFT195510(AGABI2DRAFT_195510)
DDI: DDB_G0291376(adi1)
DFA: DFA_11400(adi1)
NGD: NGA_0085400(MTND)
ENC: ECL_03088
ECLO: ENC_21190
EEC: EcWSU1_01187(mtnD)
ECLX: LI66_05760
ECLY: LI62_06660
ECLZ: LI64_06260
ESA: ESA_02726
CSK: ES15_2796(mtnD)
CTU: CTU_12360(mtnD)
KPN: KPN_00643
KPU: KP1_1594(mtnD)
KPP: A79E_3597
KPT: VK055_1890(mtnD)
KPE: KPK_3931(mtnD)
KPR: KPR_3933(mtnD)
KPJ: N559_3682
KPX: PMK1_02976(mtnD)
KPNU: LI86_18885
KPNK: BN49_1701(mtnD)
KVA: Kvar_3724
KOX: KOX_14110
KOE: A225_1640
EAE: EAE_13730
EAR: CCG31225
CKO: CKO_03973
YPS: YPTB0876
YPO: BZ17_1670(mtnD)
YPY: YPK_3319
YPB: YPTS_0917
YPQ: DJ40_1482(mtnD)
YPU: BZ21_121(mtnD)
YPR: BZ20_1171(mtnD)
YPC: BZ23_398(mtnD)
YPF: BZ19_234(mtnD)
YEN: YE3231(mntD)
YEY: Y11_21591
YEW: CH47_2599(mtnD)
YET: CH48_2607(mtnD)
YAL: AT01_1542(mtnD)
YFR: AW19_2210(mtnD)
YIN: CH53_2777(mtnD)
YKR: CH54_3576
YRO: CH64_3497(mtnD)
SPE: Spro_0944
SRL: SOD_c07990(mtnD)
SPLY: Q5A_004250(mtnD_1)
SMAF: D781_0894
SMAR: SM39_0249(mtnD)
SMAC: SMDB11_0201(mtnD)
SERF: L085_24080
RAA: Q7S_04485
SGL: SG0273
SOD: Sant_3601
DDQ: DDI_3215
ETA: ETA_26070
EAM: EAMY_0875
EAY: EAM_0887
EBI: EbC_08710
PAM: PANA_0873(mtnD)
PAJ: PAJ_0208(mtnD)
PVA: Pvag_0266
PSTW: DSJ_19580
TPTY: NCTC11468_02957(mtnD)
XFA: XF_2210
XFT: PD_1259
XCC: XCC1819
XCB: XC_2370
XCP: XCR_2070
XCV: XCV1885
XAX: XACM_1865
XAC: XAC1839
XOO: XOO2138
XOM: XOO2007(XOO2007)
XOR: XOC_2227
XAL: XALC_1321
SML: Smlt2188
SMT: Smal_1781
SMZ: SMD_1971(mtnD)
PSUW: WQ53_14315
PSD: DSC_09800
LAB: LA76x_3213(mtnD)
LAQ: GLA29479_3661(mtnD)
LCP: LC55x_3258(mtnD)
LGU: LG3211_1960(mtnD)
LEZ: GLE_1911
LEM: LEN_3079
DKO: I596_1905
PAE: PA1684
PAEV: N297_1730(mtnD)
PAEI: N296_1730(mtnD)
PAEP: PA1S_17590
PAEM: U769_17310
PAEL: T223_18645
PAEG: AI22_16395
PAEC: M802_1727(mtnD)
PAEO: M801_1729(mtnD)
PMY: Pmen_1884
PMK: MDS_1943
PRE: PCA10_37330(mtnD)
PPSE: BN5_2551
PCQ: PcP3B5_39750(mtnD)
PPU: PP_1832
PPF: Pput_3878
PPT: PPS_1473
PPI: YSA_02089
PPX: T1E_1597
PPUH: B479_07115
PPUT: L483_06690
PPUN: PP4_39470
PPUD: DW66_1759
PMON: X969_05310
PMOT: X970_05285
PSB: Psyr_1856
PSYR: N018_08655
PFL: PFL_4346
PPRC: PFLCHA0_c44180(mtnD)
PPRO: PPC_4456
PFS: PFLU_4336
PFB: VO64_5196
PMAN: OU5_5344(mtnD)
PEN: PSEEN1531
PSA: PST_2431
PSTT: CH92_08465
PPUU: PputUW4_03698(mtnD)
PKC: PKB_1889(mtnD)
PSES: PSCI_3698
PSEM: TO66_22760
PSEC: CCOS191_3841(mtnD)
PSOS: POS17_4427
PANR: A7J50_4012
PSET: THL1_3691
PSIL: PMA3_07890
PSM: PSM_A3024
PSEO: OM33_15840
PPHE: PP2015_164
PEA: PESP_a3749(mtnD)
PSPO: PSPO_b0240(mtnD)
PART: PARC_a0117(mtnD)
PTU: PTUN_a0116(mtnD)
PTD: PTET_a3414(mtnD)
PSEN: PNC201_16985(mtnD)
MAQ: Maqu_0908
MHC: MARHY2380
MAD: HP15_1261
MCA: MCA0798
MAH: MEALZ_2472(mtnD)
PSAL: PSLF89_564
NHL: Nhal_0742
NWA: Nwat_0695
TEE: Tel_07800
NTT: TAO_1470
TGR: Tgr7_2624
HCH: HCH_01845
HAM: HALO0804
ABO: ABO_1446
ADI: B5T_02226
APAC: S7S_09665
AXE: P40_10730
TOL: TOL_3009
SLIM: SCL_2744
SVA: SVA_3843
PLG: NCTC10937_01837(mtnD)
AXX: ERS451415_05675(mtnD)
DAC: Daci_3175
RGE: RGE_20920(mtnD)
DSU: Dsui_2065
CCX: COCOR_07003(mtnD)
HOH: Hoch_4249
PLA: Plav_1853
BBT: BBta_2511
RPA: RPA2352
RPT: Rpal_2596
SPHI: TS85_07965
SSAN: NX02_24545
SPHT: K426_21264
GOX: GOX1243
GOH: B932_0888
GOY: GLS_c13300(mtnD)
ACR: Acry_0018
AMV: ACMV_00180(mtnD)
GDI: GDI0586(mtnD)
GDJ: Gdia_1414
GXY: GLX_12670
GXL: H845_2505
KEU: S101446_01813(mtnD)
APK: APA386B_2240(mtnD)
ASZ: ASN_417(mtnD)
TMO: TMO_a0146(mtnD)
AFR: AFE_0433
ACU: Atc_2431
BSU: BSU13620(mtnD)
BSR: I33_1533
BSL: A7A1_1506
BSH: BSU6051_13620(mtnD)
BSUT: BSUB_01482(mtnD)
BSUL: BSUA_01482(mtnD)
BSUS: Q433_07785
BSS: BSUW23_06995(mtnD)
BST: GYO_1689
BSO: BSNT_07853(ykrZ)
BSQ: B657_13620(mtnD)
BSX: C663_1403(mtnD)
BLI: BL03542(mtnZ)
BLD: BLi01517(mtnD)
BLH: BaLi_c15970(mtnD)
BAY: RBAM_013400(mtnD)
BAQ: BACAU_1317(mtnZ)
BYA: BANAU_1276(mtnZ)
BAMP: B938_06970
BAML: BAM5036_1276(mtnD)
BAMA: RBAU_1318(mtnD)
BAMN: BASU_1297(mtnD)
BAMB: BAPNAU_2423(mtnZ)
BAMT: AJ82_07695
BAMY: V529_12920(mtnD)
BMP: NG74_01396(mtnD)
BAO: BAMF_1443(mtnD)
BAZ: BAMTA208_10325(mtnD)
BQL: LL3_01464(mtnD)
BXH: BAXH7_02111(mtnD)
BQY: MUS_1443(mtnD)
BAMI: KSO_012665
BAMC: U471_13630
BAMF: U722_07160
BATR: TD68_04060
BAN: BA_4258
BAR: GBAA_4258
BAT: BAS3949
BAI: BAA_4281
BANT: A16_42590
BANR: A16R_43130
BANS: BAPAT_4083
BANV: DJ46_2950
BCE: BC4039
BCA: BCE_4106
BCQ: BCQ_3829
BCX: BCA_4152
BNC: BCN_3951
BCF: bcf_20090
BCER: BCK_15005
BTL: BALH_3656
BTT: HD73_4338
BTHI: BTK_21355
BTM: MC28_3331(mtnD)
BTG: BTB_c41740(mtnD)
BTI: BTG_29225
BTW: BF38_5212
BWW: bwei_0912(mtnD)
BMYO: BG05_1983
BMYC: DJ92_1134
BPU: BPUM_1255
BPUM: BW16_07080
BPUS: UP12_06585
BMQ: BMQ_1253(mtnD)
BMD: BMD_1237(mtnD)
BMEG: BG04_3552
BJS: MY9_1491
BMET: BMMGA3_05060(mtnD)
BACW: QR42_06440
BACP: SB24_03015
BACB: OY17_09795
BACY: QF06_05820
BACL: BS34A_15130(mtnD)
BALM: BsLM_1443
BEO: BEH_04830
BGY: BGLY_1455(mtnD)
BKW: BkAM31D_06410(mtnD)
GKA: GK0956
GTN: GTNG_0844
GGH: GHH_c08930(mtnD)
GEA: GARCT_00968(mtnD)
AFL: Aflv_1994
AAMY: GFC30_1265
ANL: GFC29_151
MCAK: MCCS_23740(mtnD)
ESI: Exig_0427
EAN: Eab7_0402(mtnD)
BBE: BBR47_48930(mtnD)
PPY: PPE_02563
PPM: PPSC2_13705(ykrZ)
PPO: PPM_2690(ykrZ)
PPOL: X809_30105
PPOY: RE92_23030
PMS: KNP414_02920(mtnD)
PMW: B2K_15985
PLV: ERIC2_c25920(mtnD)
PSWU: SY83_17980
ASOC: CB4_03888(mtnD)
AAC: Aaci_0094
AAD: TC41_0115(mtnD)
JEO: JMA_33150
SAY: TPY_2542(mtnD)
NFR: ERS450000_02672(mtnD_1) ERS450000_05387(mtnD_2)
NNO: NONO_c39570(mtnD)
NSR: NS506_04591(mtnD)
SCT: SCAT_3260(mtnD)
SRW: TUE45_02089(mtnD)
SLE: sle_00880(sle_00880)
SMAL: SMALA_8346
SFK: KY5_1466
MTS: MTES_1960
FAL: FRAAL1410
SEN: SACE_3605
AOI: AORI_2694(mtnD)
AJA: AJAP_25350(mtnD)
AMI: Amir_0987
SESP: BN6_11440(mtnD)
KAL: KALB_7736
ACTI: UA75_13675
ACAD: UA74_13580
AHG: AHOG_12810(mtnD)
ALL: CRK55075
AYM: YM304_28010(mtnD)
SYW: SYNW0652
SYC: syc0916_c
SYG: sync_0589
SYNR: KR49_05310
SYND: KR52_06170
CYI: CBM981_1736(mtnD)
HHG: XM38_007090(mtnD)
PMT: PMT_0197
MAR: MAE_46350
MPK: VL20_5991
CYL: AA637_01920(mtnD)
TER: Tery_2668
GLJ: GKIL_1170(mtnD)
ANA: all2724
AVA: Ava_4291
NAZ: Aazo_0775
CTHE: Chro_2929
PSL: Psta_3140
PIR: VN12_23810(mtnD_2)
LIL: LB_293
LIE: LIF_B235
LIC: LIC_20227(ard)
LBJ: LBJ_4219
LBL: LBL_4233
LBF: LBF_1254
LST: LSS_08914
ABAC: LuPra_00084(mtnD)
SGN: SGRA_3041(mtnD)
AAE: aq_1975
HTH: HTH_1580
LFC: LFE_0826
MOX: DAMO_2927(mtnD)
CDIV: CPM_1787
 » show all
Taxonomy
Reference
1  [PMID:8407993]
  Authors
Wray JW, Abeles RH.
  Title
A bacterial enzyme that catalyzes formation of carbon monoxide.
  Journal
J Biol Chem 268:21466-9 (1993)
  Sequence
[kpn:KPN_00643]
Reference
2  [PMID:7852397]
  Authors
Wray JW, Abeles RH.
  Title
The methionine salvage pathway in Klebsiella pneumoniae and rat liver. Identification and characterization of two novel dioxygenases.
  Journal
J Biol Chem 270:3147-53 (1995)
DOI:10.1074/jbc.270.7.3147
Reference
3  [PMID:2838472]
  Authors
Furfine ES, Abeles RH.
  Title
Intermediates in the conversion of 5'-S-methylthioadenosine to methionine in Klebsiella pneumoniae.
  Journal
J Biol Chem 263:9598-606 (1988)
Reference
4  [PMID:9880484]
  Authors
Dai Y, Wensink PC, Abeles RH.
  Title
One protein, two enzymes.
  Journal
J Biol Chem 274:1193-5 (1999)
DOI:10.1074/jbc.274.3.1193
  Sequence
Reference
5  [PMID:10481280]
  Authors
Mo H, Dai Y, Pochapsky SS, Pochapsky TC.
  Title
1H, 13C and 15N NMR assignments for a carbon monoxide generating metalloenzyme from Klebsiella pneumoniae.
  Journal
J Biomol NMR 14:287-8 (1999)
Reference
6  [PMID:11371200]
  Authors
Dai Y, Pochapsky TC, Abeles RH.
  Title
Mechanistic studies of two dioxygenases in the methionine salvage pathway of Klebsiella pneumoniae.
  Journal
Biochemistry 40:6379-87 (2001)
DOI:10.1021/bi010110y
  Sequence
[kpn:KPN_00643]
Reference
7  [PMID:12022880]
  Authors
Al-Mjeni F, Ju T, Pochapsky TC, Maroney MJ.
  Title
XAS investigation of the structure and function of Ni in acireductone dioxygenase.
  Journal
Biochemistry 41:6761-9 (2002)
DOI:10.1021/bi012209a
Reference
8  [PMID:12402029]
  Authors
Pochapsky TC, Pochapsky SS, Ju T, Mo H, Al-Mjeni F, Maroney MJ.
  Title
Modeling and experiment yields the structure of acireductone dioxygenase from Klebsiella pneumoniae.
  Journal
Nat Struct Biol 9:966-72 (2002)
DOI:10.1038/nsb863
  Sequence
[kpn:KPN_00643]
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.54
IUBMB Enzyme Nomenclature: 1.13.11.54
ExPASy - ENZYME nomenclature database: 1.13.11.54
BRENDA, the Enzyme Database: 1.13.11.54

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