KEGG   ENZYME: 1.13.11.58Help
Entry
EC 1.13.11.58               Enzyme                                 

Name
linoleate 9S-lipoxygenase;
9-lipoxygenase;
9S-lipoxygenase;
linoleate 9-lipoxygenase;
LOX1 (gene name);
9S-LOX
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
linoleate:oxygen 9S-oxidoreductase
Reaction(IUBMB)
linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate [RN:R07057]
Reaction(KEGG)
Substrate
linoleate [CPD:C01595];
O2 [CPD:C00007]
Product
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate [CPD:C14827]
Comment
Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and alpha-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C9 position with (S)-configuration. The enzyme plays a physiological role during the early stages of seedling growth. The enzyme from Arabidopsis thaliana shows comparable activity towards linoleate and linolenate [4]. EC 1.13.11.12 (linoleate 13S-lipoxygenase) catalyses a similar reaction at another position of these fatty acids.
History
EC 1.13.11.58 created 2011
Pathway
ec00591  Linoleic acid metabolism
Orthology
K15718  linoleate 9S-lipoxygenase
Genes
RSS: 109440107
ATH: AT1G55020(LOX1) AT3G22400(LOX5)
ALY: ARALYDRAFT_474776 ARALYDRAFT_479752
CRB: 17893758 17894417
CSAT: 104701021 104706342 104715474 104746689 104746690 104748430 104750191 104758943 104766136 104787362 104787405
EUS: EUTSA_v10020023mg EUTSA_v10023267mg
BRP: 103834572 103844546 103869043
BNA: 106352821 106376623 106388246 106433608 106433973 106453908 111198039
BOE: 106295789 106314534 106319746
THJ: 104801865 104806939 104820855 104823730 104825976
LJA: Lj0g3v0057299.1(Lj0g3v0057299.1) Lj0g3v0057299.2(Lj0g3v0057299.2) Lj0g3v0126519.1(Lj0g3v0126519.1) Lj0g3v0177819.1(Lj0g3v0177819.1) Lj0g3v0255679.1(Lj0g3v0255679.1) Lj0g3v0342749.1(Lj0g3v0342749.1) Lj0g3v0342759.1(Lj0g3v0342759.1) Lj1g3v4931510.1(Lj1g3v4931510.1) Lj3g3v0323570.1(Lj3g3v0323570.1) Lj3g3v0323580.1(Lj3g3v0323580.1) Lj3g3v0324640.1(Lj3g3v0324640.1) Lj3g3v0335680.1(Lj3g3v0335680.1) Lj3g3v0335690.1(Lj3g3v0335690.1) Lj3g3v2659870.1(Lj3g3v2659870.1) Lj3g3v2661200.1(Lj3g3v2661200.1) Lj3g3v2662120.1(Lj3g3v2662120.1) Lj5g3v2056200.1(Lj5g3v2056200.1) Lj5g3v2056200.2(Lj5g3v2056200.2) Lj5g3v2056200.3(Lj5g3v2056200.3)
DOSA: Os03t0699700-01(Os03g0699700) Os03t0700700-01(Os03g0700700) Os03t0738600-01(Os03g0738600) Os11t0575600-01(Os11g0575600)
ATS: 109751942(LOC109751942) 109755494(LOC109755494) 109765406(LOC109765406) 109766078(LOC109766078) 109767522(LOC109767522) 109774264(LOC109774264) 109781224(LOC109781224) 109781225(LOC109781225) 109787375(LOC109787375)
ZMA: 100037802(LOX2) 100037803(LOX4) 100037804(LOX5) 100037805(lox6) 541856(LOX) 542495
 » show all
Taxonomy
Reference
1  [PMID:17369372]
  Authors
Vellosillo T, Martinez M, Lopez MA, Vicente J, Cascon T, Dolan L, Hamberg M, Castresana C
  Title
Oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral  root development and defense responses through a specific signaling cascade.
  Journal
Plant Cell 19:831-46 (2007)
DOI:10.1105/tpc.106.046052
  Sequence
Reference
2  [PMID:18795358]
  Authors
Boeglin WE, Itoh A, Zheng Y, Coffa G, Howe GA, Brash AR
  Title
Investigation of substrate binding and product stereochemistry issues in two linoleate 9-lipoxygenases.
  Journal
Lipids 43:979-87 (2008)
DOI:10.1007/s11745-008-3230-1
Reference
3  [PMID:19037675]
  Authors
Andreou AZ, Hornung E, Kunze S, Rosahl S, Feussner I
  Title
On the substrate binding of linoleate 9-lipoxygenases.
  Journal
Lipids 44:207-15 (2009)
DOI:10.1007/s11745-008-3264-4
  Sequence
[ath:AT1G55020] [ag:AAB31252]
Reference
4  [PMID:18949503]
  Authors
Bannenberg G, Martinez M, Hamberg M, Castresana C
  Title
Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana.
  Journal
Lipids 44:85-95 (2009)
DOI:10.1007/s11745-008-3245-7
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.58
IUBMB Enzyme Nomenclature: 1.13.11.58
ExPASy - ENZYME nomenclature database: 1.13.11.58
BRENDA, the Enzyme Database: 1.13.11.58

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