KEGG   ENZYME: 1.13.11.59Help
Entry
EC 1.13.11.59               Enzyme                                 

Name
torulene dioxygenase;
CAO-2;
CarT
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
torulene:oxygen oxidoreductase
Reaction(IUBMB)
torulene + O2 = 4'-apo-beta,psi-caroten-4'-al + 3-methylbut-2-enal [RN:R09782]
Reaction(KEGG)
Substrate
torulene [CPD:C08613];
O2 [CPD:C00007]
Product
4'-apo-beta,psi-caroten-4'-al [CPD:C19892];
3-methylbut-2-enal [CPD:C07330]
Comment
It is assumed that 3-methylbut-2-enal is formed. The enzyme cannot cleave the saturated 3',4'-bond of gamma-carotene which implies that a 3',4'-double bond is neccessary for this reaction.
History
EC 1.13.11.59 created 2011
Pathway
ec00906  Carotenoid biosynthesis
ec01100  Metabolic pathways
Orthology
K17842  torulene dioxygenase
Genes
CCP: CHC_T00003476001 CHC_T00004955001
YLI: YALI0C18029g
NCR: NCU11424(cao-2)
NTE: NEUTE1DRAFT147619(NEUTE1DRAFT_147619)
SMP: SMAC_08627
PAN: PODANSg626
TTT: THITE_2122267
MGR: MGG_08016
SSCK: SPSK_06058
FGR: FGSG_02625
MAW: MAC_04503
MAJ: MAA_07825
CMT: CCM_06728
ANI: AN1704.2
ANG: ANI_1_1676184(An04g02710)
ABE: ARB_02211
TVE: TRV_00460
PTE: PTT_16702
ABP: AGABI1DRAFT80273(AGABI1DRAFT_80273)
ABV: AGABI2DRAFT207832(AGABI2DRAFT_207832)
 » show all
Taxonomy
Reference
1  [PMID:17493127]
  Authors
Prado-Cabrero A, Estrada AF, Al-Babili S, Avalos J
  Title
Identification and biochemical characterization of a novel carotenoid oxygenase:  elucidation of the cleavage step in the Fusarium carotenoid pathway.
  Journal
Mol Microbiol 64:448-60 (2007)
DOI:10.1111/j.1365-2958.2007.05665.x
  Sequence
Reference
2  [PMID:17610084]
  Authors
Saelices L, Youssar L, Holdermann I, Al-Babili S, Avalos J
  Title
Identification of the gene responsible for torulene cleavage in the Neurospora carotenoid pathway.
  Journal
Mol Genet Genomics 278:527-37 (2007)
DOI:10.1007/s00438-007-0269-2
Reference
3  [PMID:18812228]
  Authors
Estrada AF, Maier D, Scherzinger D, Avalos J, Al-Babili S
  Title
Novel apocarotenoid intermediates in Neurospora crassa mutants imply a new biosynthetic reaction sequence leading to neurosporaxanthin formation.
  Journal
Fungal Genet Biol 45:1497-505 (2008)
DOI:10.1016/j.fgb.2008.09.001
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.59
IUBMB Enzyme Nomenclature: 1.13.11.59
ExPASy - ENZYME nomenclature database: 1.13.11.59
BRENDA, the Enzyme Database: 1.13.11.59

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