KEGG   ENZYME: 1.13.11.62Help
Entry
EC 1.13.11.62               Enzyme                                 

Name
linoleate 10R-lipoxygenase;
10R-DOX;
(10R)-dioxygenase;
10R-dioxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
linoleate:oxygen (10R)-oxidoreductase
Reaction(IUBMB)
linoleate + O2 = (8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate [RN:R09811]
Reaction(KEGG)
Substrate
linoleate [CPD:C01595];
O2 [CPD:C00007]
Product
(8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate [CPD:C19937]
Comment
The enzyme is involved in biosynthesis of oxylipins, which affect sporulation, development, and pathogenicity of Aspergillus spp.
History
EC 1.13.11.62 created 2011
Pathway
ec00591  Linoleic acid metabolism
Orthology
K17862  linoleate 10R-lipoxygenase
Genes
NHE: NECHADRAFT_40259
ANI: AN5028.2
AFM: AFUA_3G12120 AFUA_4G00180
AOR: AO090003000772
ANG: ANI_1_1118024(An02g07930)
AFV: AFLA_030430 AFLA_120760
ACT: ACLA_039980
NFI: NFIA_045480 NFIA_065200
PCS: Pc18g00240
CIM: CIMG_00042
ABE: ARB_07881
 » show all
Taxonomy
Reference
1  [PMID:19289462]
  Authors
Garscha U, Oliw EH
  Title
Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase  with epoxyalcohol synthase activity.
  Journal
J Biol Chem 284:13755-65 (2009)
DOI:10.1074/jbc.M808665200
  Sequence
Reference
2  [PMID:20045744]
  Authors
Jerneren F, Garscha U, Hoffmann I, Hamberg M, Oliw EH
  Title
Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus.
  Journal
Biochim Biophys Acta 1801:503-7 (2010)
DOI:10.1016/j.bbalip.2009.12.012
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.62
IUBMB Enzyme Nomenclature: 1.13.11.62
ExPASy - ENZYME nomenclature database: 1.13.11.62
BRENDA, the Enzyme Database: 1.13.11.62

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