KEGG   ENZYME: 1.13.11.71Help
Entry
EC 1.13.11.71               Enzyme                                 

Name
carotenoid-9',10'-cleaving dioxygenase;
BCO2 (gene name);
beta-carotene 9',10'-monooxygenase (misleading);
all-trans-beta-carotene:O2 oxidoreductase (9',10'-cleaving)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
all-trans-beta-carotene:oxygen oxidoreductase (9',10'-cleaving)
Reaction(IUBMB)
all-trans-beta-carotene + O2 = all-trans-10'-apo-beta-carotenal + beta-ionone [RN:R10559]
Reaction(KEGG)
Substrate
all-trans-beta-carotene [CPD:C02094];
O2 [CPD:C00007]
Product
all-trans-10'-apo-beta-carotenal [CPD:C20695];
beta-ionone [CPD:C12287]
Comment
Requires Fe2+. The enzyme catalyses the asymmetric oxidative cleavage of carotenoids. The mammalian enzyme can also cleave all-trans-lycopene.
History
EC 1.13.11.71 created 2012
Orthology
K10252  beta,beta-carotene 9',10'-dioxygenase
Genes
HSA: 83875(BCO2)
PTR: 451548(BCO2)
PPS: 100968503(BCO2)
GGO: 101146575(BCO2)
PON: 100434189(BCO2)
NLE: 100585752(BCO2)
MCC: 712095(BCO2)
MCF: 102136772(BCO2)
CSAB: 103248467(BCO2)
RRO: 104659457 104677360(BCO2)
RBB: 108536440(BCO2)
CJC: 100397428(BCO2)
SBQ: 101053395(BCO2)
MMU: 170752(Bco2)
RNO: 315644(Bco2)
CGE: 100774947(Bco2)
NGI: 103733876(Bco2)
HGL: 101704023(Bco2)
CCAN: 109699438(Bco2)
OCU: 100344631(BCO2)
TUP: 102485450(BCO2)
CFA: 479437(BCO2)
AML: 100482102(SDHD)
UMR: 103662381(SDHD)
ORO: 101370083(BCO2)
FCA: 101095765(BCO2)
AJU: 106986370
BTA: 514135(BCO2)
BOM: 102280946
BIU: 109569909(BCO2)
PHD: 102335122(BCO2)
CHX: 102176146(BCO2)
SSC: 100517547(BCO2)
CFR: 102520302(BCO2)
CDK: 105094181(BCO2)
BACU: 103012517(BCO2)
LVE: 103086674(BCO2)
OOR: 101288737(BCO2)
ECB: 100070518(BCO2)
EPZ: 103565878(BCO2)
EAI: 106840222(BCO2)
MYB: 102262734(BCO2)
MYD: 102751608(PTS) 102756952(BCO2)
HAI: 109394784(BCO2)
RSS: 109436575(BCO2)
PALE: 102884496(BCO2)
TMU: 101357485
MDO: 100032246(BCO2)
SHR: 100919673(BCO2)
OAA: 100087018(BCO2)
GGA: 419792(BCO2)
MGP: 100549031(BCO2)
CJO: 107324119(BCO2)
APLA: 101802069(BCO2)
ACYG: 106039773(BCO2)
TGU: 100217865 100220531(BCO2)
GFR: 102041586(BCO2)
FAB: 101819010(BCO2)
PHI: 102105953(BCO2)
PMAJ: 107214399(BCO2)
CCAE: 111939279(BCO2)
CCW: 104692076(BCO2)
FPG: 101911275(BCO2)
FCH: 102054794(BCO2)
CLV: 102093604(BCO2)
EGZ: 104125905(BCO2)
AAM: 106495924(BCO2)
ASN: 102369219(BCO2)
AMJ: 102569970(BCO2)
PSS: 102463932(BCO2)
CMY: 102946859(BCO2)
CPIC: 101953792(BCO2)
ACS: 100568148(bco2)
PVT: 110078727(BCO2)
PBI: 103051556(BCO2)
GJA: 107116138(BCO2)
XLA: 108696498(xpo) 446869(bco2.L)
XTR: 100487224 448408(bco2)
DRE: 678554(bco2b) 793849(bco2a) 84041(bco2l)
IPU: 108260373(bco2) 108260375
LCO: 104917970(bco2) 104922805
CSEM: 103377768(bco2) 103398249
MALB: 109957023 109959541(bco2)
SFM: 108928652(bco2) 108936233
LCM: 102356793(BCO2)
CMK: 103190786(bco2)
CLEC: 106669856
ZNE: 110827803
ADF: 107351383
SMIN: v1.2.036047.t1(symbB.v1.2.036047.t1)
 » show all
Taxonomy
Reference
1  [PMID:11278918]
  Authors
Kiefer C, Hessel S, Lampert JM, Vogt K, Lederer MO, Breithaupt DE, von Lintig J
  Title
Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A.
  Journal
J Biol Chem 276:14110-6 (2001)
DOI:10.1074/jbc.M011510200
  Sequence
[hsa:83875] [mmu:170752] [dre:84041]
Reference
2  [PMID:15983114]
  Authors
Lindqvist A, He YG, Andersson S
  Title
Cell type-specific expression of beta-carotene 9',10'-monooxygenase in human tissues.
  Journal
J Histochem Cytochem 53:1403-12 (2005)
DOI:10.1369/jhc.5A6705.2005
  Sequence
[hsa:83875]
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.71
IUBMB Enzyme Nomenclature: 1.13.11.71
ExPASy - ENZYME nomenclature database: 1.13.11.71
BRENDA, the Enzyme Database: 1.13.11.71

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