KEGG   ENZYME: 1.13.11.8Help
Entry
EC 1.13.11.8                Enzyme                                 

Name
protocatechuate 4,5-dioxygenase;
protocatechuate 4,5-oxygenase;
protocatechuic 4,5-dioxygenase;
protocatechuic 4,5-oxygenase;
protocatechuate:oxygen 4,5-oxidoreductase (decyclizing);
protocatechuate:oxygen 4,5-oxidoreductase (ring-opening)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
3,4-dihydroxybenzoate:oxygen 4,5-oxidoreductase (ring-opening)
Reaction(IUBMB)
3,4-dihydroxybenzoate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde [RN:R01632]
Reaction(KEGG)
Substrate
3,4-dihydroxybenzoate [CPD:C00230];
O2 [CPD:C00007]
Product
4-carboxy-2-hydroxymuconate semialdehyde [CPD:C04484]
Comment
Requires Fe2+.
History
EC 1.13.11.8 created 1965 as EC 1.13.1.8, transferred 1972 to EC 1.13.11.8
Pathway
ec00362  Benzoate degradation
ec00624  Polycyclic aromatic hydrocarbon degradation
ec00627  Aminobenzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K04100  protocatechuate 4,5-dioxygenase, alpha chain
K04101  protocatechuate 4,5-dioxygenase, beta chain
Genes
XCC: XCC0804(pcaH) XCC0805(ligA)
XCB: XC_3426 XC_3427
XCA: xcc-b100_3546(ligA) xcc-b100_3547(ligB)
XCP: XCR_0984 XCR_0985
XCV: XCV0913(ligB) XCV0914(ligA)
XAX: XACM_0859(ligB) XACM_0860
XAC: XAC0878(pcaH) XAC0879(ligA)
XCI: XCAW_03701(ligA) XCAW_03702(pcaH)
XCT: J151_01005 J151_01006
XCJ: J158_01002 J158_01003
XOO: XOO3734(pcaH)
XOM: XOO3524(XOO3524) XOO3525(XOO3525)
XOP: PXO_04631
XPH: XppCFBP6546_07115(XppCFBP6546P_07115) XppCFBP6546_07120(XppCFBP6546P_07120)
PPUT: L483_17500
RFO: REIFOR_00545(ligA) REIFOR_00546(ligB)
KKI: KKKWG1_0313(ligB)
HYF: DTO96_100892(ligA_1) DTO96_100893(ligB)
AFQ: AFA_05515 AFA_05520(ligA)
VEI: Veis_1369
LIM: L103DPR2_01497(ligA_1) L103DPR2_01498(ligB_1) L103DPR2_01514(ligA_2) L103DPR2_01515(ligB_2)
LIH: L63ED372_01144(ligA_1) L63ED372_01145(ligB)
AZO: azo2522(ligB1) azo2523(ligA1) azo2537(ligB2) azo2538(ligA2)
BRA: BRADO2341(ligA) BRADO2342(ligB) BRADO2379 BRADO2380(mhpB)
BBT: BBta_2701(ligA) BBta_2702(ligB) BBta_2733 BBta_2734(mhpB)
BRO: BRAD285_4958(ligB) BRAD285_4959(ligA) BRAD285_4995(ligB) BRAD285_4996(ligA)
RPA: RPA1006 RPA1007(mhpB) RPA4701(ligA) RPA4702(ligB)
MMED: Mame_04593(ligB)
SPHP: LH20_03910
SPHR: BSY17_3446(ligB) BSY17_3447(ligA)
BLAS: BSY18_3523(ligA) BSY18_3524(ligB)
AAY: WYH_01045(ligB_1) WYH_01046(ligA_2) WYH_01908(ligA_3) WYH_01909(ligB_2) WYH_03214(ligB_3) WYH_03215(ligA_4)
ADO: A6F68_01079(ligB) A6F68_01080(ligA_1)
TMO: TMO_b0114 TMO_b0115(mhpB)
MAGQ: MGMAQ_2661(ligB) MGMAQ_2662(ligA) MGMAQ_2669(ligA) MGMAQ_2670(ligB)
AUW: AURUGA1_00419(ligA_1) AURUGA1_00420(ligB)
BSD: BLASA_2598(ligA) BLASA_2599(ligB)
MMAR: MODMU_2843(ligB) MODMU_2844(ligA) MODMU_3384
PSEA: WY02_25080
ACTN: L083_0820
AFS: AFR_03865
AFO: Afer_2021
PYR: P186_1889
POG: Pogu_1799
 » show all
Taxonomy
Reference
1
  Authors
Trippett, S., Dagley, S. and Stopher, D.A.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
Biochem J 76:9 (1960)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.8
IUBMB Enzyme Nomenclature: 1.13.11.8
ExPASy - ENZYME nomenclature database: 1.13.11.8
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.8
BRENDA, the Enzyme Database: 1.13.11.8
CAS: 9029-56-5

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