KEGG   ENZYME: 1.13.11.9Help
Entry
EC 1.13.11.9                Enzyme                                 

Name
2,5-dihydroxypyridine 5,6-dioxygenase;
2,5-dihydroxypyridine oxygenase;
pyridine-2,5-diol dioxygenase;
NicX
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase
Reaction(IUBMB)
2,5-dihydroxypyridine + O2 = N-formylmaleamic acid [RN:R09125]
Reaction(KEGG)
Substrate
2,5-dihydroxypyridine [CPD:C01059];
O2 [CPD:C00007]
Product
N-formylmaleamic acid [CPD:C18232]
Comment
Requires Fe2+.
History
EC 1.13.11.9 created 1965 as EC 1.13.1.9, transferred 1972 to EC 1.13.11.9, modified 2010
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K18028  2,5-dihydroxypyridine 5,6-dioxygenase
Genes
GQU: AWC35_02975
SPE: Spro_2312
SRR: SerAS9_2269
SRL: SOD_c21420(nicX)
SRY: M621_11735
SPLY: Q5A_011870(nicX)
SRS: SerAS12_2269
SRA: SerAS13_2270
SMW: SMWW4_v1c23260
SMAR: SM39_1771
SERF: L085_17115
PPU: PP_3945(nicX)
PPF: Pput_1892
PPT: PPS_4058
PPI: YSA_08963
PPX: T1E_5122
PPUT: L483_21715
PPUN: PP4_17770
PFS: PFLU_2800
PFB: VO64_0127
PANR: A7J50_2717
PSIL: PMA3_12570
HAM: HALO0548
ADI: B5T_02297
REH: H16_A0925(h16_A0925) H16_B0813(h16_B0813)
CGD: CR3_0579(ampS) CR3_0803(ampS) CR3_3007(nicX)
BCN: Bcen_4327
BCJ: BCAM1142
BCEN: DM39_3879
BCEO: I35_4989
BMU: Bmul_4550
BMK: DM80_3720
BMUL: NP80_4069
BCED: DM42_3948
BCON: NL30_06920
BSEM: WJ12_25610
BPSL: WS57_08415
BMEC: WJ16_24240
BSTG: WT74_20825
BGO: BM43_2599
BXE: Bxe_C0216
BXB: DR64_8215
BFN: OI25_6799
PPNO: DA70_23280
PPNM: LV28_07430
PPUL: RO07_01615
PAPI: SG18_01755
BPET: B1917_3473
AFQ: AFA_13575 AFA_14965(nicX) AFA_15135(picD) AFA_18565(hpaX)
ODI: ODI_R3898
AAV: Aave_3930
AAA: Acav_3827
DAC: Daci_1850
CTES: O987_23190
LIM: L103DPR2_00582(nicX)
LIH: L63ED372_00060(nicX)
HYB: Q5W_22175
RLG: Rleg_6046
SHZ: shn_30285
OCH: CES85_3503(nicX)
BRS: S23_21870
AOL: S58_52840
BRAD: BF49_5545
PHL: KKY_3788
HDI: HDIA_0234(nicX)
CID: P73_3892
LVS: LOKVESSMR4R_03232(nicX)
GXL: H845_1042
KEU: S101446_01672(nicX)
MVQ: MYVA_3797
RFA: A3L23_03312(nicX)
RHS: A3Q41_00020(nicX)
SALU: DC74_1449
SALL: SAZ_07780
STRE: GZL_07763
SMAL: SMALA_0613
FAL: FRAAL6169
AOI: AORI_4776
AJA: AJAP_15760(nicX)
PSEA: WY02_22100
PSEE: FRP1_20590
PSEH: XF36_05315
 » show all
Taxonomy
Reference
1  [PMID:13475371]
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
2  [PMID:5578917]
  Authors
Gauthier JJ, Rittenberg SC.
  Title
The metabolism of nicotinic acid. I. Purification and properties of 2,5-dihydroxypyridine oxygenase from Pseudomonas putida N-9.
  Journal
J Biol Chem 246:3737-42 (1971)
  Sequence
[ppu:PP_3945]
Reference
3  [PMID:5578918]
  Authors
Gauthier JJ, Rittenberg SC.
  Title
The metabolism of nicotinic acid. II. 2,5-dihydroxypyridine oxidation, product formation, and oxygen 18 incorporation.
  Journal
J Biol Chem 246:3743-8 (1971)
  Sequence
[ppu:PP_3945]
Reference
4  [PMID:18678916]
  Authors
Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E
  Title
Deciphering the genetic determinants for aerobic nicotinic acid degradation: the  nic cluster from Pseudomonas putida KT2440.
  Journal
Proc Natl Acad Sci U S A 105:11329-34 (2008)
DOI:10.1073/pnas.0802273105
  Sequence
[ppu:PP_3945]
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.9
IUBMB Enzyme Nomenclature: 1.13.11.9
ExPASy - ENZYME nomenclature database: 1.13.11.9
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.9
BRENDA, the Enzyme Database: 1.13.11.9
CAS: 9029-57-6

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