KEGG   ENZYME: 1.13.12.19Help
Entry
EC 1.13.12.19               Enzyme                                 

Name
2-oxoglutarate dioxygenase (ethene-forming);
ethylene-forming enzyme;
EFE;
2-oxoglutarate dioxygenase (ethylene-forming);
2-oxoglutarate:oxygen oxidoreductase (decarboxylating, ethylene-forming)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
BRITE hierarchy
Sysname
2-oxoglutarate:oxygen oxidoreductase (decarboxylating, ethene-forming)
Reaction(IUBMB)
2-oxoglutarate + O2 = ethene + 3 CO2 + H2O [RN:R09784]
Reaction(KEGG)
Substrate
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
ethene [CPD:C06547];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
This is one of two simultaneous reactions catalysed by the enzyme, which is responsible for ethene production in bacteria of the Pseudomonas syringae group. In the other reaction [EC 1.14.20.7, 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)] the enzyme catalyses the mono-oxygenation of both 2-oxoglutarate and L-arginine, forming succinate, carbon dioxide and L-hydroxyarginine, which is subsequently cleaved into guanidine and (S)-1-pyrroline-5-carboxylate.The enzymes catalyse two cycles of the ethene-forming reaction for each cycle of the succinate-forming reaction, so that the stoichiometry of the products ethene and succinate is 2:1.
History
EC 1.13.12.19 created 2011
Orthology
K21815  2-oxoglutarate dioxygenase / 2-oxoglutarate/L-arginine monooxygenase/decarboxylase
Genes
XOR: XOC_2500
RSO: RSp1529(efe)
RSL: RPSI07_mp1626(efe)
RSN: RSPO_m00454(efe)
RSM: CMR15_mp30178(efe)
RSE: F504_5001
MSD: MYSTI_05925
SCB: SCAB_86241
FRI: FraEuI1c_2575
AMD: AMED_9132
AMN: RAM_46840
AMM: AMES_8995
AMZ: B737_8996
 » show all
Taxonomy
Reference
1  [PMID:1770346]
  Authors
Nagahama K, Ogawa T, Fujii T, Tazaki M, Tanase S, Morino Y, Fukuda H
  Title
Purification and properties of an ethylene-forming enzyme from Pseudomonas syringae pv. phaseolicola PK2.
  Journal
J Gen Microbiol 137:2281-6 (1991)
DOI:10.1099/00221287-137-10-2281
  Sequence
Reference
2  [PMID:1445291]
  Authors
Fukuda H, Ogawa T, Tazaki M, Nagahama K, Fujii T, Tanase S, Morino Y
  Title
Two reactions are simultaneously catalyzed by a single enzyme: the arginine-dependent simultaneous formation of two products, ethylene and succinate, from 2-oxoglutarate by an enzyme from Pseudomonas syringae.
  Journal
Biochem Biophys Res Commun 188:483-9 (1992)
DOI:10.1016/0006-291X(92)91081-Z
  Sequence
Reference
3  [PMID:1445325]
  Authors
Fukuda H, Ogawa T, Ishihara K, Fujii T, Nagahama K, Omata T, Inoue Y, Tanase S, Morino Y
  Title
Molecular cloning in Escherichia coli, expression, and nucleotide sequence of the gene for the ethylene-forming enzyme of Pseudomonas syringae pv. phaseolicola PK2.
  Journal
Biochem Biophys Res Commun 188:826-32 (1992)
DOI:10.1016/0006-291X(92)91131-9
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.12.19
IUBMB Enzyme Nomenclature: 1.13.12.19
ExPASy - ENZYME nomenclature database: 1.13.12.19
BRENDA, the Enzyme Database: 1.13.12.19

DBGET integrated database retrieval system