KEGG   ENZYME: 1.13.12.3Help
Entry
EC 1.13.12.3                Enzyme                                 

Name
tryptophan 2-monooxygenase;
tms1 (gene name);
iaaM (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
BRITE hierarchy
Sysname
L-tryptophan:oxygen 2-oxidoreductase (decarboxylating)
Reaction(IUBMB)
L-tryptophan + O2 = (indol-3-yl)acetamide + CO2 + H2O [RN:R00679]
Reaction(KEGG)
Substrate
L-tryptophan [CPD:C00078];
O2 [CPD:C00007]
Product
(indol-3-yl)acetamide [CPD:C02693];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
The enzyme, studied from phytopathogenic bacteria such as Pseudomonas savastanoi, is involved in a pathway for the production of (indol-3-yl)acetate (IAA), the main auxin hormone in plants.
History
EC 1.13.12.3 created 1972
Pathway
ec00380  Tryptophan metabolism
Orthology
K00466  tryptophan 2-monooxygenase
Genes
DDD: Dda3937_01279(iaaM)
DZE: Dd1591_3740
DDQ: DDI_0143
XPO: XPG1_3347(iaaM)
PAP: PSPA7_3191
PRE: PCA10_04900
PCQ: PcP3B5_32620(iaaM)
PPU: PP_0383(davB)
PPF: Pput_0407
PPG: PputGB1_0411
PPI: YSA_05771
PPX: T1E_2171
PPUH: B479_02390
PPUT: L483_01950
PPUN: PP4_04120
PPUD: DW66_0391
PSYR: N018_02455
PFL: PFL_5670
PPRC: PFLCHA0_c56220(iaaM)
PPRO: PPC_5615
PMAN: OU5_4020
PEN: PSEEN0401
PPUU: PputUW4_04962(iaaM)
PKC: PKB_2893
PSES: PSCI_1278
PSOS: POS17_5602
PANR: A7J50_5326
PSET: THL1_442
PSIL: PMA3_27685
GAI: IMCC3135_25895(iaaM)
BPSE: BDL_5500
BPSD: BBX_4666
BVE: AK36_4384
BSEM: WJ12_25165
BUG: BC1001_PA6282(iaaM)
BUK: MYA_4068
BXE: Bxe_C1245
BXB: DR64_8566
BPH: Bphy_7769
HYB: Q5W_21180
ATU: Atu6011(tms1)
ATF: Ach5_51170(tms1)
AVI: Avi_8288(tms1)
RDE: RD1_1495
KRO: BVG79_p1000114(iaaM)
CID: P73_2156
SPSE: SULPSESMR1_04820(iaaM)
ACR: Acry_2670
MAB: MAB_0818
MABO: NF82_04135
ASD: AS9A_4558
RER: RER_05790
REY: O5Y_02765
ROP: ROP_33250
RHB: NY08_2002
RFA: A3L23_00334(iaaM)
RHS: A3Q41_03073(iaaM)
TPR: Tpau_1414
SCO: SCO1454(SCL6.11c)
SGR: SGR_6070
SGB: WQO_05045
SCT: SCAT_5364
SFA: Sfla_5404
SHY: SHJG_2887
SVE: SVEN_1051
SALB: XNR_5396
SALS: SLNWT_6481
STRP: F750_1215
SFI: SFUL_973
SALU: DC74_1908
SALL: SAZ_10120
STRE: GZL_07240
SPRI: SPRI_6108
SRW: TUE45_01867(iaaM)
SLE: sle_56450(sle_56450)
SRN: A4G23_00701(iaaM)
STRD: NI25_31935
SLAU: SLA_0954
SALJ: SMD11_5570
SLX: SLAV_08180(iaaM1) SLAV_30455(iaaM2)
SFK: KY5_1236c
ART: Arth_1110
ARR: ARUE_c11570(iaaM)
AAU: AAur_1221
ACH: Achl_1186
PSIM: KR76_13980
NDA: Ndas_3618
NAL: B005_0760
GOB: Gobs_1732
KRA: Krad_1432
AMD: AMED_6946
AMN: RAM_35635
AMM: AMES_6839
AMZ: B737_6839
PSEA: WY02_17480
PSEE: FRP1_25145
PSEH: XF36_24010
SESP: BN6_37070
CAI: Caci_8157
 » show all
Taxonomy
Reference
1  [PMID:5916389]
  Authors
Kosuge T, Heskett MG, Wilson EE.
  Title
Microbial synthesis and degradation of indole-3-acetic acid. I. The conversion of L-tryptophan to indole-3-acetamide by an enzyme system from Pseudomonas savastanoi.
  Journal
J Biol Chem 241:3738-44 (1966)
Reference
2
  Authors
Kuo, T.T. and Kosuge, T.
  Title
Factors influencing the production and further metabolism of indole-3-acetic acid by Pseudomonas savastanoi.
  Journal
J Gen Appl Microbiol 15:51-63 (1969)
Reference
3  [PMID:3997822]
  Authors
Hutcheson SW, Kosuge T
  Title
Regulation of 3-indoleacetic acid production in Pseudomonas syringae pv. savastanoi. Purification and properties of tryptophan 2-monooxygenase.
  Journal
J Biol Chem 260:6281-7 (1985)
Reference
4
  Authors
Onckelen, H.V., Prinsen, E., Inze, D., Ruedeisheim, P., Lijsebettens, M.V., Follin, A., Schell, J., Montagu, M.V. and Greef, J.D.
  Title
AgrobacteriumT-DNA gene1codes for tryptophan 2-monooxygenase activity in tobacco crown gall cells.
  Journal
FEBS Lett 198:357-360 (1986)
Reference
5  [PMID:7893667]
  Authors
Emanuele JJ, Fitzpatrick PF
  Title
Mechanistic studies of the flavoprotein tryptophan 2-monooxygenase. 1. Kinetic mechanism.
  Journal
Biochemistry 34:3710-5 (1995)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.12.3
IUBMB Enzyme Nomenclature: 1.13.12.3
ExPASy - ENZYME nomenclature database: 1.13.12.3
BRENDA, the Enzyme Database: 1.13.12.3
CAS: 37256-65-8

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