KEGG   ENZYME: 1.13.99.3Help
Entry
EC 1.13.99.3                Enzyme                                 

Name
tryptophan 2'-dioxygenase;
indole-3-alkane alpha-hydroxylase;
tryptophan side-chain alpha,beta-oxidase;
tryptophan side chain oxidase II;
tryptophan side-chain oxidase;
TSO;
indolyl-3-alkan alpha-hydroxylase;
tryptophan side chain oxidase type I;
TSO I ;
TSO II;
tryptophan side chain oxidase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
Miscellaneous
BRITE hierarchy
Sysname
L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)
Reaction(IUBMB)
L-tryptophan + O2 = (indol-3-yl)glycolaldehyde + CO2 + NH3 [RN:R00681]
Reaction(KEGG)
Substrate
L-tryptophan [CPD:C00078];
O2 [CPD:C00007]
Product
(indol-3-yl)glycolaldehyde [CPD:C03230];
CO2 [CPD:C00011];
NH3 [CPD:C00014]
Comment
A hemoprotein. Acts on a number of indole-3-alkane derivatives, oxidizing the 3-side-chain in the 2'-position. Best substrates were L-tryptophan and 5-hydroxy-L-tryptophan.
History
EC 1.13.99.3 created 1984
Pathway
ec00380  Tryptophan metabolism
Reference
1  [PMID:15994]
  Authors
Roberts J, Rosenfeld HJ.
  Title
Isolation, crystallization, and properties of indolyl-3-alkane alpha-hydroxylase. A novel tryptophan-metabolizing enzyme.
  Journal
J Biol Chem 252:2640-7 (1977)
Reference
2  [PMID:15995]
  Authors
Takai K, Ushiro H, Noda Y, Narumiya S, Tokuyama T.
  Title
Crystalline hemoprotein from Pseudomonas that catalyzes oxidation of side chain of tryptophan and other indole derivatives.
  Journal
J Biol Chem 252:2648-56 (1977)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.99.3
IUBMB Enzyme Nomenclature: 1.13.99.3
ExPASy - ENZYME nomenclature database: 1.13.99.3
BRENDA, the Enzyme Database: 1.13.99.3
CAS: 64295-81-4

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