KEGG   ENZYME: 1.14.11.1Help
Entry
EC 1.14.11.1                Enzyme                                 

Name
gamma-butyrobetaine dioxygenase;
alpha-butyrobetaine hydroxylase;
gamma-butyrobetaine hydroxylase;
butyrobetaine hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2 [RN:R02397]
Reaction(KEGG)
Substrate
4-trimethylammoniobutanoate [CPD:C01181];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
3-hydroxy-4-trimethylammoniobutanoate [CPD:C00487];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and ascorbate.
History
EC 1.14.11.1 created 1972
Pathway
ec00310  Lysine degradation
Orthology
K00471  gamma-butyrobetaine dioxygenase
Genes
HSA: 8424(BBOX1)
PTR: 466474(BBOX1)
PPS: 100987653(BBOX1)
GGO: 101131986(BBOX1)
PON: 100173794(BBOX1)
NLE: 100592137(BBOX1)
MCC: 100425366(BBOX1) 699465(BBOX1)
MCF: 101864912(BBOX1)
CSAB: 103238580(BBOX1)
RRO: 104671120(BBOX1)
RBB: 108523305(BBOX1) 108534462
CJC: 100394422(BBOX1)
SBQ: 101035393(BBOX1)
MMU: 170442(Bbox1)
RNO: 64564(Bbox1)
CGE: 100759730(Bbox1)
NGI: 103741027(Bbox1)
HGL: 101702765(Bbox1)
CCAN: 109680391(Bbox1)
OCU: 100356171(BBOX1)
TUP: 102477622(BBOX1)
CFA: 476894(BBOX1)
AML: 100467920(BBOX1)
UMR: 103659370(BBOX1)
ORO: 101381928(BBOX1)
FCA: 101082182(BBOX1)
PTG: 102966727(BBOX1)
AJU: 106970275(BBOX1)
BTA: 507159(BBOX1)
BOM: 102278682(BBOX1)
BIU: 109569931(BBOX1)
PHD: 102315518(BBOX1)
CHX: 102179499(BBOX1)
OAS: 101115823(BBOX1)
SSC: 100519353(BBOX1)
CFR: 102512431(BBOX1)
CDK: 105106403(BBOX1)
BACU: 103016705(BBOX1)
LVE: 103082783(BBOX1)
OOR: 101280530(BBOX1)
ECB: 100072253(BBOX1)
EPZ: 103552651(BBOX1)
EAI: 106824925(BBOX1)
MYB: 102248153(BBOX1)
MYD: 102755785(BBOX1)
HAI: 109373324(BBOX1)
RSS: 109456738(BBOX1)
PALE: 102894724(BBOX1)
LAV: 100668456(BBOX1)
TMU: 101348989
MDO: 100030745(BBOX1)
SHR: 100933762(BBOX1)
OAA: 100080259(BBOX1)
GGA: 426932(BBOX1)
MGP: 100548089(BBOX1)
CJO: 107314364(BBOX1)
APLA: 101793349(BBOX1)
ACYG: 106033948(BBOX1)
TGU: 100222550(BBOX1)
GFR: 102042420(BBOX1)
FAB: 101821064(BBOX1)
PHI: 102106518(BBOX1) 106628479
PMAJ: 107206111(BBOX1)
CCAE: 111930481(BBOX1)
CCW: 104692930(BBOX1)
FPG: 101921157(BBOX1)
FCH: 102053623(BBOX1)
CLV: 102092334(BBOX1)
EGZ: 104125702(BBOX1)
AAM: 106498227(BBOX1)
ASN: 102382469(BBOX1)
AMJ: 102567742(BBOX1)
PSS: 102444784(BBOX1)
CMY: 102936607(BBOX1)
CPIC: 101940563(BBOX1)
ACS: 100561261(bbox1)
PVT: 110077403(BBOX1)
PBI: 103066330(BBOX1)
GJA: 107122568(BBOX1)
XLA: 108715211(bbox1.S)
XTR: 100145728(bbox1)
NPR: 108793134(BBOX1)
DRE: 572649(bbox1)
IPU: 108259295(bbox1)
AMEX: 103030022(bbox1) 111196817
TRU: 101071219(bbox1)
LCO: 104920628(bbox1)
NCC: 104955316(bbox1)
MZE: 101466552(bbox1)
OLA: 101162990(bbox1)
XMA: 102227274(bbox1)
PRET: 103462718(bbox1)
NFU: 107381956(bbox1)
KMR: 108234810(bbox1)
CSEM: 103378801(bbox1)
LCF: 108887814(bbox1)
SDU: 111223802(bbox1)
HCQ: 109525776(bbox1)
BPEC: 110162466(bbox1)
MALB: 109965062(bbox1)
ELS: 105025966(bbox1)
SFM: 108942260(bbox1)
LCM: 102355837(BBOX1)
CMK: 103174979(bbox1)
CIN: 100180618
SPU: 577198
DME: Dmel_CG10814(CG10814) Dmel_CG4335(CG4335) Dmel_CG5321(CG5321)
DER: 6550626
DPE: 6590266
DSI: Dsimw501_GD16541(Dsim_GD16541) Dsimw501_GD17176(Dsim_GD17176) Dsimw501_GD25765(Dsim_GD25765)
DWI: 6652911
AAG: 5572067
BMOR: 101743493
PMAC: 106716042
PRAP: 110993693
HAW: 110380306
PXY: 105390519
ZNE: 110833534
FCD: 110852279
CEL: CELE_D2089.5(gbh-1) CELE_M05D6.7(gbh-2)
CBR: CBG03032(Cbr-gbh-1)
HMG: 101238208
PIC: PICST_33061(GBO1)
SMIN: v1.2.003014.t1(symbB.v1.2.003014.t1) v1.2.010310.t1(symbB.v1.2.010310.t1) v1.2.041171.t1(symbB.v1.2.041171.t1)
VTA: B1462
PMY: Pmen_0503
PFL: PFL_5756
PPRO: PPC_5702
PFS: PFLU_4654
PMAN: OU5_3943
PSEM: TO66_29120
PSOS: POS17_5690
PANR: A7J50_5402
PSIL: PMA3_28055
HAM: HALO1690
SALN: SALB1_1515
BPS: BPSS1110
BPSE: BDL_4396
BPSM: BBQ_5061
BPSU: BBN_4535
BPSD: BBX_3561
BPK: BBK_6001
BPSH: DR55_4217
BPSA: BBU_4952
BPSO: X996_4311
BUT: X994_6047
BVE: AK36_3372
BCN: Bcen_3320
BCJ: BCAM2290
BCEW: DM40_4990
BCEO: I35_6181
BAM: Bamb_4455
BCED: DM42_5701
BDL: AK34_3509
BCON: NL30_01110
BUB: BW23_3453
BLAT: WK25_27430
BTEI: WS51_08470
BSEM: WJ12_31340
BMEC: WJ16_29790
BSTG: WT74_30165
BGU: KS03_4173
BGO: BM43_4216
BUK: MYA_3007
HOH: Hoch_4369
MLO: mll1440
AVI: Avi_3411
RBM: TEF_17550
SIL: SPO3380
MMAE: MMARE11_06410(tauD_1)
MLI: MULP_00691(tauD_1)
SALJ: SMD11_6780
KSK: KSE_56020
LMOI: VV02_08475
PSEA: WY02_15675
PSEE: FRP1_27130
PSEH: XF36_26945
KAL: KALB_3391
 » show all
Taxonomy
Reference
1  [PMID:4396068]
  Authors
Lindstedt G, Lindstedt S.
  Title
Cofactor requirements of gamma-butyrobetaine hydroxylase from rat liver.
  Journal
J Biol Chem 245:4178-86 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.1
IUBMB Enzyme Nomenclature: 1.14.11.1
ExPASy - ENZYME nomenclature database: 1.14.11.1
BRENDA, the Enzyme Database: 1.14.11.1
CAS: 9045-31-2

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