KEGG   ENZYME: 1.14.11.16Help
Entry
EC 1.14.11.16               Enzyme                                 

Name
peptide-aspartate beta-dioxygenase;
aspartate beta-hydroxylase;
aspartylpeptide beta-dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
peptide-L-aspartate + 2-oxoglutarate + O2 = peptide-3-hydroxy-L-aspartate + succinate + CO2 [RN:R04073]
Reaction(KEGG)
Substrate
peptide-L-aspartate;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
peptide-3-hydroxy-L-aspartate;
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+. Some vitamin K-dependent coagulation factors, as well as synthetic peptides based on the structure of the first epidermal growth factor domain of human coagulation factor IX or X, can act as acceptors.
History
EC 1.14.11.16 created 1992
Orthology
K00476  aspartate beta-hydroxylase
Genes
HSA: 444(ASPH)
PTR: 464202(ASPH)
PPS: 100977040(ASPH)
GGO: 101139593(ASPH)
PON: 100189667(ASPH)
NLE: 100581524(ASPH)
MCC: 699884(ASPH)
MCF: 101925502(ASPH)
CSAB: 103236861(ASPH)
RRO: 104660101(ASPH)
RBB: 108543145(ASPH)
CJC: 100403503(ASPH)
SBQ: 101045507(ASPH)
MMU: 65973(Asph)
RNO: 312981(Asph)
CGE: 100755768(Asph)
NGI: 103737741(Asph)
HGL: 101725986(Asph)
CCAN: 109678257 109697332(Asph)
OCU: 100008743(ASPH) 108176505
TUP: 102478772(ASPH)
CFA: 403846(ASPH)
AML: 100479314(ASPH) 109489064
UMR: 103677467(ASPH)
ORO: 101373057(ASPH)
FCA: 105260207(ASPH)
PTG: 102960536(ASPH)
AJU: 106973810(ASPH)
BTA: 286771(ASPH)
BOM: 102285100(ASPH) 106701278
BIU: 109568307(ASPH)
PHD: 102341776(ASPH)
CHX: 102189496(ASPH)
OAS: 101118195(ASPH)
SSC: 100526167(ASPH)
CFR: 102505456(ASPH)
CDK: 105093932(ASPH)
BACU: 103017679(ASPH)
LVE: 103068515(ASPH)
OOR: 101274120(ASPH)
ECB: 100065909(ASPH)
EPZ: 103547567(ASPH)
EAI: 106843667(ASPH)
MYB: 102255804(ASPH)
MYD: 102769038(ASPH)
HAI: 109377781 109392555(ASPH)
RSS: 109458623(ASPH)
PALE: 102885216(ASPH)
LAV: 100670793(ASPH)
TMU: 101360914
MDO: 100029689(ASPH)
SHR: 100923835(ASPH)
OAA: 100082566(ASPH)
GGA: 421142(ASPH)
MGP: 100540272(ASPH)
CJO: 107310216(ASPH)
APLA: 101796017(ASPH)
ACYG: 106039040(ASPH)
GFR: 102038570(ASPH)
FAB: 101809173(ASPH)
PHI: 102100401(ASPH)
PMAJ: 107199898(ASPH)
CCAE: 111924696(ASPH)
CCW: 104690358(ASPH)
FPG: 101911221(ASPH)
FCH: 102046157(ASPH)
CLV: 102097223(ASPH)
EGZ: 104127600(ASPH)
AAM: 106494372(ASPH)
AMJ: 102572092(ASPH)
PSS: 102460072(ASPH)
CMY: 102937266(ASPH)
CPIC: 101934659(ASPH)
ACS: 100563401(asph) 107982748
PVT: 110088966(ASPH)
PBI: 103048046(ASPH)
GJA: 107114049(ASPH)
XLA: 100137711(asph.L) 108695316
XTR: 548451(asph)
NPR: 108791345(ASPH) 108796606
DRE: 559236(unm_hu7910)
AMEX: 103023508(asph) 103042371
TRU: 101061760 101072889(asph)
LCO: 104932208(asph)
PRET: 103456947(asph)
NFU: 107384363 107395322(asph)
CSEM: 103377197 103396808(asph)
LCF: 108884981(asph)
SDU: 111237396(asph)
HCQ: 109515224(asph)
BPEC: 110155726 110163976(asph)
SFM: 108929627(asph)
CMK: 103180766(asph)
CIN: 100185342
APLC: 110979582
SKO: 100369952
DME: Dmel_CG8421(Asph)
DSI: Dsimw501_GD11159(Dsim_GD11159)
MDE: 101896755
AAG: 5566108
BIM: 100741740
BTER: 110119633
AEC: 105151125
ACEP: 105619868
HST: 105187020
DQU: 106744918
CFO: 105258212
LHU: 105675763
PGC: 109863593
PCF: 106788602
MDL: 103568298
TCA: 656627
DPA: 109540998
NVL: 108563626
BMOR: 101746449
PMAC: 106709062
PRAP: 110994810
HAW: 110383774
CLEC: 106670352
ZNE: 110834569
CEL: CELE_K09A9.6(K09A9.6)
CBR: CBG07728
BMY: Bm1_33860
TSP: Tsp_03380
CRG: 105324538
MYI: 110454515
OBI: 106878285
LAK: 106164016
EPA: 110241474
ADF: 107336775
MIS: MICPUN_107436(AAH)
SMIN: v1.2.002447.t1(symbB.v1.2.002447.t1) v1.2.004766.t1(symbB.v1.2.004766.t1) v1.2.008170.t1(symbB.v1.2.008170.t1) v1.2.009162.t1(symbB.v1.2.009162.t1) v1.2.011486.t1(symbB.v1.2.011486.t1) v1.2.016784.t2(symbB.v1.2.016784.t2) v1.2.017558.t1(symbB.v1.2.017558.t1) v1.2.017824.t1(symbB.v1.2.017824.t1) v1.2.034247.t1(symbB.v1.2.034247.t1) v1.2.039705.t1(symbB.v1.2.039705.t1)
SPE: Spro_3198
SPLY: Q5A_016760
SMAR: SM39_2723
SERF: L085_12380
AMAL: I607_20347
AMAE: I876_01435
AMAO: I634_01535
AMAI: I635_21639
LPN: lpg2463
LPF: lpl2383
LPP: lpp2530
LPC: LPC_2013
BMA: BMAA0571
BMAI: DM57_12665
BMAF: DM51_4292
BMAZ: BM44_4841
BMAB: BM45_4892
BPS: BPSS1421
BPSE: BDL_4728
BPSM: BBQ_4727
BPSU: BBN_4866
BPSD: BBX_3891
BPK: BBK_4030
BPSH: DR55_3854
BPSA: BBU_4617
BPSO: X996_3642
BUT: X994_5697
BTQ: BTQ_4266
BTJ: BTJ_5304
BTZ: BTL_3766
BTD: BTI_3913
BTV: BTHA_4117
BTHE: BTN_3892
BTHM: BTRA_3763
BTHA: DR62_3934
BTHL: BG87_3722
BOK: DM82_5577
BOC: BG90_5033
BVE: AK36_3296
BCN: Bcen_3204
BCJ: BCAM2401
BCEN: DM39_5439
BCEW: DM40_3067
BCEO: I35_6299
BAM: Bamb_4559
BMU: Bmul_3492
BMK: DM80_4883
BMUL: NP80_5043
BCT: GEM_3287
BCED: DM42_5585
BDL: AK34_3415
BCON: NL30_00395
BUB: BW23_3625
BLAT: WK25_27910
BTEI: WS51_08995
BSEM: WJ12_31980
BPSL: WS57_02085
BMEC: WJ16_30505
BGU: KS03_5435
BGO: BM43_4267
BUK: MYA_3088
BUL: BW21_5907
MLO: mll1937
SYND: KR52_00915
 » show all
Taxonomy
Reference
1  [PMID:2187868]
  Authors
Gronke RS, Welsch DJ, VanDusen WJ, Garsky VM, Sardana MK, Stern AM, Friedman PA.
  Title
Partial purification and characterization of bovine liver aspartyl beta-hydroxylase.
  Journal
J Biol Chem 265:8558-65 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.16
IUBMB Enzyme Nomenclature: 1.14.11.16
ExPASy - ENZYME nomenclature database: 1.14.11.16
BRENDA, the Enzyme Database: 1.14.11.16
CAS: 122544-66-5

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