KEGG   ENZYME: 1.14.11.27Help
Entry
EC 1.14.11.27               Enzyme                                 

Name
[histone-H3]-lysine-36 demethylase;
JHDM1A;
JmjC domain-containing histone demethylase 1A;
H3-K36-specific demethylase;
histone-lysine (H3-K36) demethylase;
histone demethylase;
protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
protein N6,N6-dimethyl-L-lysine + 2 2-oxoglutarate + 2 O2 = protein L-lysine + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction) [RN:R10056];
(1a) protein N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2 = protein N6-methyl-L-lysine + succinate + formaldehyde + CO2 [RN:R09510];
(1b) protein N6-methyl-L-lysine + 2-oxoglutarate + O2 = protein L-lysine + succinate + formaldehyde + CO2 [RN:R09511]
Reaction(KEGG)
Substrate
protein N6,N6-dimethyl-L-lysine [CPD:C05545];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
protein N6-methyl-L-lysine [CPD:C05544]
Product
protein L-lysine;
succinate [CPD:C00042];
formaldehyde [CPD:C00067];
CO2 [CPD:C00011];
protein N6-methyl-L-lysine [CPD:C05544]
Comment
Requires iron(II). Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys-36. Lysine residues exist in three methylation states (mono-, di- and trimethylated). The enzyme preferentially demethylates the dimethyl form of Lys-36 (K36me2), which is its natural substrate, to form the monomethyl and unmethylated forms of Lys-36. It can also demethylate the monomethyl- but not the trimethyl form of Lys-36.
History
EC 1.14.11.27 created 2006
Orthology
K10276  F-box and leucine-rich repeat protein 10/11
K10277  lysine-specific demethylase 8
K16914  bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
K19415  lysine-specific demethylase PHF8
Genes
HSA: 22992(KDM2A) 23133(PHF8) 79697(RIOX1) 79831(KDM8) 84678(KDM2B)
PTR: 104002100(RIOX1) 107967129(KDM2A) 454003(KDM8) 465184(KDM2B) 465652(PHF8)
PPS: 100968297(KDM8) 100973092(PHF8) 100983162(KDM2A) 100988129(KDM2B) 103787047(RIOX1)
GGO: 101133194(PHF8) 101140212(KDM2A) 101154151(KDM2B) 101154296(KDM8) 109025036 109025211 109028723
PON: 100434567(KDM2A) 100449217(KDM8) 100461475(PHF8) 100462645(KDM2B) 103892384(RIOX1)
NLE: 100579905(KDM2B) 100586240(KDM8) 100601220(PHF8) 100601545(KDM2A) 105739243(RIOX1)
MCC: 696773(RIOX1) 699938(KDM2B) 703323(KDM8) 703633(PHF8) 712907(KDM2A)
MCF: 102125851(KDM2B) 102128432(PHF8) 102130596(KDM8) 102135352(RIOX1) 102142242(KDM2A)
CSAB: 103219229(KDM2A) 103229309(RIOX1) 103230060(KDM8) 103232021(PHF8) 103239283(KDM2B)
RRO: 104656344(RIOX1) 104664750(KDM2A) 104665634(KDM8) 104666275(KDM2B) 104666278 104682297(PHF8)
RBB: 108518607(KDM2A) 108521261 108521720 108529633(KDM2B) 108536225(RIOX1) 108538874(KDM8)
CJC: 100397900(KDM2B) 100403232(KDM2A) 100404196(RIOX1) 100405966(PHF8) 100411932(KDM8) 103791420
SBQ: 101038744(PHF8) 101044630(KDM2B) 101047692(KDM8) 101049444(KDM2A) 104650789
MMU: 225876(Kdm2a) 30841(Kdm2b) 320595(Phf8) 71952(Riox1) 77035(Kdm8)
RNO: 304495(Kdm2b) 308976(Kdm8) 314300(RGD1307704) 317425(Phf8) 361700(Kdm2a)
CGE: 100756628(Phf8) 100762777(Kdm8) 100763039(Kdm2a) 100767158(Kdm2b) 100774109 103158922 103161768(Riox1)
NGI: 103725573(Kdm2a) 103739068(Kdm2b) 103741037(Kdm8) 103747314(Phf8) 103747411(Riox1)
HGL: 101696346(Kdm2b) 101702352(Kdm8) 101712659(Riox1) 101713712(Kdm2a) 101716284(Phf8)
CCAN: 109678510(Phf8) 109684942 109684944(Kdm2a) 109686393(Kdm2b) 109691362(Riox1) 109698038(Kdm8)
OCU: 100344764(PHF8) 100349603(KDM2B) 100352993(KDM2A) 100358867(KDM8) 103351690(RIOX1)
TUP: 102471383(KDM8) 102482421(KDM2A) 102482466(PHF8) 102484507(RIOX1) 102488934(KDM2B)
CFA: 106559177(RIOX1) 483702(KDM2A) 486262(KDM2B) 491897(PHF8) 608058(KDM8)
AML: 100467038(KDM2B) 100468557(RIOX1) 100469601(KDM2A) 100475840(KDM8) 100481292(PHF8)
UMR: 103657901(KDM8) 103661272(KDM2B) 103673481(RIOX1) 103679509(KDM2A) 103681294(PHF8)
ORO: 101368265(PHF8) 101368497(KDM2B) 101372656(KDM8) 101379219 101385046(KDM2A)
FCA: 101090549(KDM2A) 101092337(PHF8) 101094455(KDM2B) 101096528(KDM8) 102900260(RIOX1)
PTG: 102950473(KDM8) 102951883(PHF8) 102959050(KDM2A) 102960977(RIOX1) 102971585(KDM2B)
AJU: 106966184(KDM8) 106967547(KDM2B) 106971187(KDM2A) 106974332(RIOX1) 106985228(PHF8)
BTA: 507905(KDM8) 511031(RIOX1) 513959(PHF8) 540141(KDM2A) 614487(KDM2B)
BOM: 102264590(KDM8) 102274509(KDM2B) 102283438(PHF8) 102285244(RIOX1) 102286032(KDM2A)
BIU: 109554334(KDM2A) 109554894(PHF8) 109565323(RIOX1) 109571124(KDM2B) 109578552(KDM8)
PHD: 102316176(KDM2B) 102319685 102322396(KDM2A) 102329240(RIOX1) 102333064(PHF8) 102344908(KDM8)
CHX: 102173094(RIOX1) 102180467(KDM2A) 102180525(KDM2B) 102186078(KDM8) 102186671 108634296(PHF8)
OAS: 101103759(KDM2B) 101108003(KDM2A) 101108800(KDM8) 101118668(PHF8) 105602104 105606501(C7H14orf169)
SSC: 100294703(KDM2A) 100512074(KDM2B) 100519765(KDM8) 100520413(PHF8) 100523074(RIOX1)
CFR: 102503719(KDM2B) 102504419(KDM8) 102505373(RIOX1) 102518453(PHF8) 102523384(KDM2A)
CDK: 105086126(RIOX1) 105093683(PHF8) 105098259(KDM8) 105102511(KDM2B) 105104438(KDM2A)
BACU: 103000580(PHF8) 103004183(KDM2B) 103010328 103014019(RIOX1) 103016454(KDM8) 103019182(KDM2A)
LVE: 103068693 103069841(RIOX1) 103071419(PHF8) 103076521(KDM2A) 103086446(KDM8) 103088952(KDM2B)
OOR: 101275960 101280158(KDM2B) 101280561(KDM8) 101283255(KDM2A) 101287099(PHF8)
ECB: 100052955(KDM2A) 100059690(KDM2B) 100060410(PHF8) 100064574(KDM8) 100146448(RIOX1)
EAI: 106827349(PHF8) 106827705(RIOX1) 106829079(KDM8) 106833507(KDM2A) 106842217(KDM2B)
MYB: 102241201(PHF8) 102249116(KDM2A) 102253219(KDM2B) 102256784(RIOX1) 102259370(KDM8)
MYD: 102751904(KDM2B) 102752152(KDM8) 102757410(RIOX1) 102759691(PHF8) 102768553(KDM2A)
HAI: 109381570(RIOX1) 109384201(KDM2A) 109386110(KDM2B) 109386576(KDM8) 109396386(PHF8)
RSS: 109434124(PHF8) 109438480(KDM8) 109448262(CUNH14orf169) 109448556(KDM2B) 109450438(KDM2A)
PALE: 102883377(KDM2B) 102887644(RIOX1) 102893335(KDM8) 102893981(KDM2A) 102894028(PHF8)
LAV: 100654538(KDM8) 100660627(PHF8) 100668526(RIOX1) 100669609(KDM2B) 100672180(KDM2A)
MDO: 100015947(KDM2B) 100016278(KDM8) 100019755(PHF8) 100024523(RIOX1) 100029240(KDM2A)
SHR: 100914942(PHF8) 100921054(KDM8) 100924459(KDM2B) 100925042(KDM2A) 105749436 105750349(RIOX1)
OAA: 100078761(PHF8) 100079268(KDM8) 100079482(KDM2B) 100084241(KDM2A) 100086314(RIOX1)
GGA: 416583(KDM8) 416844(KDM2B) 423249(C5H14ORF169) 425999(KDM2A)
MGP: 100541114(KDM8) 100544042(KDM2B) 100545882(RIOX1) 100551270(KDM2A)
CJO: 107314187(KDM2A) 107314864(RIOX1) 107320716(KDM8) 107321115(KDM2B)
APLA: 101791557(KDM2B) 101795359(KDM2A) 101796369(KDM8) 101796505(RIOX1)
ACYG: 106029324(KDM2A) 106031144(KDM2B) 106040700 106046025(KDM8)
TGU: 100218907(KDM2B) 100219109(RIOX1) 100221235(KDM8) 100230512(KDM2A)
GFR: 102033306(KDM2A) 102035608(RIOX1) 102044247(KDM8) 102045075(KDM2B)
FAB: 101809416(KDM8) 101813982(KDM2B) 101818982(KDM2A) 101819482(RIOX1)
PHI: 102107110(KDM8) 102111633(RIOX1) 102113870(KDM2B) 102114250(KDM2A)
PMAJ: 107205486(C5H14orf169) 107206215(KDM2A) 107211302(KDM8) 107211564(KDM2B)
CCAE: 111930251(RIOX1) 111930406(KDM2A) 111936304(KDM8) 111936391(KDM2B) 111945915
CCW: 104684132 104685073(KDM8) 104688287(RIOX1) 104688702(KDM2B)
FPG: 101912390(KDM2B) 101913407(KDM8) 101914594(KDM2A) 101922675(RIOX1) 101923116(PHF8)
FCH: 102050781(KDM2B) 102052310(KDM2A) 102052952(RIOX1) 102059772(PHF8) 102060265(KDM8)
CLV: 102084883(KDM2B) 102085791(RIOX1) 102088060(KDM8) 102096388(KDM2A) 110356542
EGZ: 104129653(KDM2A) 104130143(KDM2B) 104131350(KDM8) 104132280
AAM: 106486126(KDM8) 106493402(KDM2A) 106495671(KDM2B) 106497482 106497483 106498095(RIOX1)
ASN: 102367801(PHF8) 102376489(RIOX1) 102379559(KDM2B) 102386519(KDM8) 102388715(KDM2A)
AMJ: 102560036(RIOX1) 102565389(KDM2A) 102575621(KDM8) 102576916(PHF8) 106736919(KDM2B)
PSS: 102446014(KDM2B) 102450180(RIOX1) 102452607 102454325 102458369(KDM8) 102464032(KDM2A)
CMY: 102933242(RIOX1) 102933550(KDM2B) 102946953(KDM2A) 102947016(KDM8)
CPIC: 101931158(PHF8) 101941489(KDM2B) 101944320(KDM2A) 101944361(KDM8) 101944414(RIOX1)
ACS: 100555582(kdm2a) 100557128(kdm2b) 100557464(riox1) 100560548(kdm8) 100566919(phf8)
PVT: 110078613(PHF8) 110083885(KDM2B) 110085034(KDM8) 110085628(KDM2A) 110088098(RIOX1)
PBI: 103055385(KDM2B) 103057322(PHF8) 103063143(KDM8) 103064072(RIOX1) 103064363(KDM2A)
GJA: 107106235(KDM8) 107109113(KDM2A) 107111814(RIOX1) 107115877 107115913 107120718(PHF8)
XTR: 100158649(kdm8) 100488246(c14orf169) 448624(kdm2b) 496596(kdm2a) 733740(phf8)
NPR: 108786201(KDM8) 108787819(KDM2B) 108788943(CUNH14orf169) 108790443(PHF8) 108801104(KDM2A)
DRE: 100536129 436936(kdm8) 560815(riox1) 566534(phf8) 799441(kdm2ab)
IPU: 100528124(kdm8) 108257725(riox1) 108262769 108264901(kdm2b) 108268705(kdm2a) 108276206(phf8)
AMEX: 103024695 103030174 103034250(kdm2b) 103035470(riox1) 103038657(phf8) 103039345(kdm2a) 103044249(kdm8)
CSEM: 103381232(c7h14orf169) 103384305 103384580(phf8) 103390456 103390943(kdm2a) 103392783(kdm8) 103398071(kdm2b)
LCF: 108872906 108873507(cunh14orf169) 108876399(phf8) 108878302(kdm2a) 108878436 108879821 108903012(kdm8)
ELS: 105013404(kdm8) 105013526(phf8) 105014887 105017561(riox1) 105022887 105024850(kdm2b) 105028557(kdm2a)
LCM: 102352369(RIOX1) 102358334(KDM2A) 102360659(PHF8) 102360974(KDM8) 102363992(KDM2B) 106702246
CMK: 103174084(phf8) 103180532(fbxl19) 103181758(riox1) 103184391(kdm2b) 103186634(kdm8)
CIN: 100179691 100181325 778852(zf(cxxc)-1)
DME: Dmel_CG11033(Kdm2) Dmel_CG13902(CG13902) Dmel_CG2982(CG2982)
DSI: Dsimw501_GD13505(Dsim_GD13505) Dsimw501_GD18594(Dsim_GD18594)
CEL: CELE_C06H2.3(jmjd-5) CELE_T26A5.5(jhdm-1) CELE_T28F2.4(jmjc-1)
ATH: AT3G20810(JMJD5)
CRB: 17891861
BRP: 103869271(JMJ30)
BOE: 106344094
THJ: 104816908
CPAP: 110811807
CIT: 102619679
TCC: 18589751
GRA: 105772548
VRA: 106755596
VAR: 108338976
LJA: Lj3g3v3271520.1(Lj3g3v3271520.1) Lj3g3v3271520.2(Lj3g3v3271520.2) Lj4g3v2140190.2(Lj4g3v2140190.2)
ADU: 107476784
AIP: 107629002
FVE: 101301573
PPER: 18774862
PMUM: 103341839
PAVI: 110770961
PXB: 103963740
ZJU: 107412622
CSV: 101210592
CMO: 103492075
MCHA: 111021407
JCU: 105650478
POP: 7496047
VVI: 100267241
SLY: 101251119(JMJ524)
SPEN: 107003102
SOT: 102591001
NSY: 104226658
NTO: 104094942
OEU: 111380176
CCAV: 112522168
DCR: 108227309
BVG: 104889940
SOE: 110801981
NNU: 104597503
DOSA: Os08t0508500-00(Os08g0508500) Os09t0489200-00(Os09g0489200)
ATS: 109731690(LOC109731690) 109755349(LOC109755349)
PDA: 103711389
EGU: 105050222
DCT: 110098668
ATR: 18439881
MNG: MNEG_6536
SCE: YER051W(JHD1)
ERC: Ecym_4349
KMX: KLMA_40344(JHD1)
TPF: TPHA_0C01220(TPHA0C01220)
TDL: TDEL_0H02210(TDEL0H02210)
CAL: CAALFM_CR00750CA(CaO19.3281)
CAUR: QG37_01522
SLB: AWJ20_3653(JHD1)
NCR: NCU10760
NTE: NEUTE1DRAFT79510(NEUTE1DRAFT_79510)
MGR: MGG_01543
SSCK: SPSK_04177
MAW: MAC_09414
MAJ: MAA_01258
CMT: CCM_04182
MBE: MBM_01658
ANG: ANI_1_3296014(An01g13820) ANI_1_3330024(An02g14310)
PBL: PAAG_01011 PAAG_11435(PAAG_02164)
SPO: SPCC622.16c(epe1)
ABP: AGABI1DRAFT53243(AGABI1DRAFT_53243)
ABV: AGABI2DRAFT216606(AGABI2DRAFT_216606)
DDI: DDB_G0270906(jcdD) DDB_G0286391(jcdC) DDB_G0287513(jcdG) DDB_G0290765(jcdA)
DFA: DFA_08281(jcdD) DFA_09741(jcdA) DFA_11649(jcdC) DFA_11703(jcdG) DFA_11942(jcdF)
SMIN: v1.2.004901.t1(symbB.v1.2.004901.t1) v1.2.006676.t1(symbB.v1.2.006676.t1) v1.2.016310.t2(symbB.v1.2.016310.t2) v1.2.016310.t3(symbB.v1.2.016310.t3) v1.2.022129.t1(symbB.v1.2.022129.t1) v1.2.037862.t1(symbB.v1.2.037862.t1)
TCR: 508141.30
SOD: Sant_0816
AMAL: I607_20302
AMAE: I876_01390
AMAO: I634_01490
AMAI: I635_21594
AOL: S58_72420
SLD: T261_7856
MARF: CJ739_3374
 » show all
Taxonomy
Reference
1  [PMID:16362057]
  Authors
Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y.
  Title
Histone demethylation by a family of JmjC domain-containing proteins.
  Journal
Nature 439:811-6 (2006)
DOI:10.1038/nature04433
  Sequence
[hsa:22992 84678] [sce:YER051W]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.27
IUBMB Enzyme Nomenclature: 1.14.11.27
ExPASy - ENZYME nomenclature database: 1.14.11.27
BRENDA, the Enzyme Database: 1.14.11.27

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