KEGG   ENZYME: 1.14.11.4Help
Entry
EC 1.14.11.4                Enzyme                                 

Name
procollagen-lysine 5-dioxygenase;
lysine hydroxylase;
lysine,2-oxoglutarate 5-dioxygenase;
protocollagen lysine dioxygenase;
collagen lysine hydroxylase;
lysine-2-oxoglutarate dioxygenase;
lysyl hydroxylase;
lysylprotocollagen dioxygenase;
protocollagen lysyl hydroxylase;
peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase;
peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase;
protocollagen lysine hydroxylase;
procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating);
L-lysine-[procollagen],2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
[procollagen]-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)
Reaction(IUBMB)
[procollagen]-L-lysine + 2-oxoglutarate + O2 = [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2 [RN:R03376]
Reaction(KEGG)
Substrate
[procollagen]-L-lysine;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
[procollagen]-(2S,5R)-5-hydroxy-L-lysine [CPD:C01211];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and ascorbate.
History
EC 1.14.11.4 created 1972, modified 1983
Pathway
ec00310  Lysine degradation
Orthology
K00473  procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
K13645  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
K13646  lysyl hydroxylase/galactosyltransferase/glucosyltransferase
K13647  procollagen-lysine,2-oxoglutarate 5-dioxygenase, invertebrate
K21236  procollagen lysyl hydroxylase and glycosyltransferase
Genes
HSA: 5351(PLOD1) 5352(PLOD2) 8985(PLOD3)
PTR: 457956(PLOD1) 460754(PLOD2) 463618(PLOD3)
PPS: 100968399(PLOD3) 100969240(PLOD2) 100973324(PLOD1)
GGO: 101123821(PLOD2) 101141181(PLOD1) 101151570(PLOD3)
PON: 100174498(PLOD1) 100189797(PLOD3) 100460115(PLOD2)
NLE: 100597272(PLOD3) 100598845(PLOD1) 100605215(PLOD2)
MCC: 714283(PLOD3) 715820(PLOD2) 722763(PLOD1)
MCF: 101865444(PLOD1) 101866274(PLOD2) 101867014(PLOD3)
CSAB: 103225979(PLOD1) 103241535(PLOD2) 103246688(PLOD3)
RRO: 104657553(PLOD1) 104662391(PLOD2) 104681188(PLOD3)
RBB: 108518931(PLOD3) 108539328(PLOD1) 108540316(PLOD2)
CJC: 100390092(PLOD3) 100393790(PLOD1) 100409327(PLOD2)
SBQ: 101036449(PLOD1) 101039285(PLOD2) 101043341(PLOD3)
MMU: 18822(Plod1) 26432(Plod2) 26433(Plod3)
RNO: 116552(Plod1) 288583(Plod3) 300901(Plod2)
CGE: 100762939(Plod2) 100763844(Plod1)
NGI: 103733492(Plod3) 103740758(Plod2) 103747474(Plod1)
HGL: 101701075(Plod3) 101708679(Plod2) 101716463(Plod1)
TUP: 102475334(PLOD1) 102476916(PLOD3) 102495899(PLOD2)
CFA: 479730(PLOD3) 485702(PLOD2) 487440(PLOD1)
AML: 100467680(PLOD2) 100472371(PLOD1) 100484476(PLOD3)
UMR: 103666856(PLOD1) 103670197(PLOD3) 103681519(PLOD2)
ORO: 101369558(PLOD1) 101373342(PLOD2) 101383290(PLOD3)
FCA: 101085741(PLOD2) 101089668(PLOD3) 101100822(PLOD1)
PTG: 102950927(PLOD3) 102968272(PLOD1) 102970252(PLOD2)
AJU: 106971863(PLOD1) 106975178(PLOD2) 106988106(PLOD3)
BTA: 281409(PLOD1) 514996(PLOD3) 533642(PLOD2)
BOM: 102276636(PLOD3) 102281451(PLOD2) 102288243(PLOD1)
BIU: 109559474(PLOD2) 109570554(PLOD1) 109578633(PLOD3)
PHD: 102317489(PLOD2) 102321876(PLOD3) 102325667(PLOD1)
CHX: 100861039(PLOD3) 102168374(PLOD1) 102176366(PLOD2)
OAS: 101103613(PLOD2) 101111306(PLOD1) 101121738(PLOD3)
SSC: 100525583(PLOD1) 100624420(PLOD3) 641354(PLOD2)
CFR: 102505707(PLOD3) 102508417(PLOD1) 102512817(PLOD2)
CDK: 105092397(PLOD3) 105096764(PLOD2) 105107039(PLOD1)
BACU: 102997634(PLOD2) 103018042(PLOD3) 103020558(PLOD1)
LVE: 103080972(PLOD1) 103086765 103090004(PLOD2) 103090807(PLOD3)
OOR: 101271625(PLOD2) 101272678(PLOD3) 101289080(PLOD1)
ECB: 100050902(PLOD1) 100059479(PLOD3) 100061030(PLOD2)
EPZ: 103547353(PLOD2) 103552180(PLOD1) 103566973(PLOD3)
EAI: 106823925(PLOD2) 106836665(PLOD1) 106839342(PLOD3)
MYB: 102249872(PLOD3) 102257428(PLOD1) 102259135(PLOD2)
MYD: 102753806(PLOD2) 102755224(PLOD3) 102762645(PLOD1)
HAI: 109375944(PLOD2) 109381293(PLOD1) 109385048(PLOD3)
RSS: 109437458(PLOD2) 109458817(PLOD3) 109460667(PLOD1)
PALE: 102879015(PLOD3) 102881554(PLOD1) 102893099(PLOD2)
LAV: 100657833(PLOD1) 100659652(PLOD2) 100675876(PLOD3)
MDO: 100017782(PLOD3) 100017955(PLOD1) 100018666(PLOD2)
SHR: 100921874(PLOD3) 100928031(PLOD2) 100928370(PLOD1)
OAA: 100074679(PLOD2) 100076869(PLOD1) 100086224(PLOD3)
GGA: 419485(PLOD1) 424882(PLOD2)
MGP: 100542606(PLOD1) 100544189(PLOD2)
CJO: 107318094(PLOD2) 107323370(PLOD1)
APLA: 101789966(PLOD1) 101803465(PLOD2)
ACYG: 106036169(PLOD2) 106040199(PLOD1)
TGU: 100217784(PLOD1) 100224084(PLOD2)
GFR: 102035759(PLOD2) 102038926(PLOD1)
FAB: 101811005(PLOD2) 101816277(PLOD1)
PHI: 102103019(PLOD2) 102110217(PLOD1)
PMAJ: 107208890(PLOD2) 107213713(PLOD1)
CCAE: 111933495(PLOD2) 111938717(PLOD1)
CCW: 104693245(PLOD1) 104693463(PLOD2)
FPG: 101910585(PLOD2) 101912951(PLOD1)
FCH: 102049083(PLOD2) 102058202(PLOD1)
CLV: 102087276(PLOD2) 102088770(PLOD1)
EGZ: 104127078(PLOD2) 104133143(PLOD1)
AAM: 106482461(PLOD1) 106485827(PLOD2)
AMJ: 102561107(PLOD3) 102572097(PLOD2) 102572760(PLOD1)
PSS: 102444474(PLOD3) 102445695 102447271(PLOD1)
CMY: 102934230(PLOD1) 102938302(PLOD2)
CPIC: 101943910(PLOD3) 101944198(PLOD1) 101949154(PLOD2)
ACS: 100558042(plod3) 100558233(plod2) 103282406(plod1)
PVT: 110073214(PLOD1) 110087641(PLOD3) 110091206(PLOD2)
PBI: 103051832(PLOD3) 103054432(PLOD2) 103065765(PLOD1) 103067401
GJA: 107111573(PLOD1) 107112451(PLOD2) 107118151(PLOD3)
XLA: 108717073(plod2.L) 108718143(plod2.S) 380138(plod3.L) 398437(plod1.S) 495112(plod1.L) 495489
XTR: 100489636(plod2) 734090(plod3) 779793(plod1)
NPR: 108798039(PLOD2) 108799425(PLOD1) 108800474(PLOD3)
DRE: 100036767(plod2) 556077(plod3) 777635(plod1a)
IPU: 108265030(plod1) 108272656(plod2) 108275691(plod3)
TRU: 100101241(plod1) 100101242(plod3) 100101243(plod2)
LCO: 104933041(plod1) 104937263(plod2)
NCC: 104967336(plod1)
OLA: 101154842(plod3) 101160794(plod1) 101171207(plod2)
XMA: 102223949 102230892(plod2) 102234789(plod1)
PRET: 103456927(plod2) 103460325 103466985(plod1)
KMR: 108229759 108230460(plod2) 108250888(plod1)
CSEM: 103377154(plod2) 103384866(plod1) 103389255
SDU: 111233777(plod1) 111237911(plod2) 111239991
HCQ: 109518414(plod3) 109519490(plod2) 109528507(plod1)
BPEC: 110165616(plod1) 110170034(plod2) 110174873
MALB: 109951041(plod1) 109952454(plod3) 109954107 109961443(plod2)
SASA: 100196315(plod3) 106572195(plod1) 106579751 106590681
ELS: 105005915(plod2) 105008588 105013858(plod1)
SFM: 108920367(plod3) 108923182 108924878(plod1) 108927772(plod2) 108934983
LCM: 102347396(PLOD3) 102357354(PLOD1) 102364901(PLOD2)
CMK: 103177516(plod2) 103181397(plod1)
CIN: 100178986
SPU: 576306
DME: Dmel_CG6199(Plod)
DER: 6543814
DSI: Dsimw501_GD12814(Dsim_GD12814)
DWI: 6645854
AAG: 5570134
AME: 100578909
BIM: 100745672
BTER: 100645351
SOC: 105201584
AEC: 105143839
ACEP: 105620057
HST: 105189644
CFO: 105249535
LHU: 105678519
PGC: 109855880
NVI: 100117467
TCA: 662642
DPA: 109537317
NVL: 108567706
BMOR: 101743038
PMAC: 106717249
PRAP: 110995385
PXY: 105394559
API: 100162555
DNX: 107164149
ZNE: 110827234
TUT: 107363543
CEL: CELE_F52H3.1(let-268)
CBR: CBG13377(Cbr-let-268)
BMY: Bm1_42125
TSP: Tsp_03029
MYI: 110462775
LAK: 106160356
EPA: 110241798
ADF: 107346845
HMG: 100212717
 » show all
Taxonomy
Reference
1  [PMID:6033801]
  Authors
Hausmann E.
  Title
Cofactor requirements for the enzymatic hydroxylation of lysine in a polypeptide precursor of collagen.
  Journal
Biochim Biophys Acta 133:591-3 (1967)
DOI:10.1016/0005-2795(67)90566-1
Reference
2  [PMID:5244754]
  Authors
Rhoads RE, Udenfriend S.
  Title
Decarboxylation of alpha-ketoglutarate coupled to collagen proline hydroxylase.
  Journal
Proc Natl Acad Sci U S A 60:1473-8 (1968)
DOI:10.1073/pnas.60.4.1473
Reference
3  [PMID:6766066]
  Authors
Puistola U, Turpeenniemi-Hujanen TM, Myllyla R, Kivirikko KI
  Title
Studies on the lysyl hydroxylase reaction. I. Initial velocity kinetics and related aspects.
  Journal
Biochim Biophys Acta 611:40-50 (1980)
DOI:10.1016/0005-2744(80)90040-6
Reference
4  [PMID:6766067]
  Authors
Puistola U, Turpeenniemi-Hujanen TM, Myllyla R, Kivirikko KI
  Title
Studies on the lysyl hydroxylase reaction. II. Inhibition kinetics and the reaction mechanism.
  Journal
Biochim Biophys Acta 611:51-60 (1980)
DOI:10.1016/0005-2744(80)90041-8
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.4
IUBMB Enzyme Nomenclature: 1.14.11.4
ExPASy - ENZYME nomenclature database: 1.14.11.4
BRENDA, the Enzyme Database: 1.14.11.4
CAS: 9059-25-0

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