KEGG   ENZYME: 1.14.11.8Help
Entry
EC 1.14.11.8                Enzyme                                 

Name
trimethyllysine dioxygenase;
trimethyllysine alpha-ketoglutarate dioxygenase;
TML-alpha-ketoglutarate dioxygenase;
TML hydroxylase;
6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2 [RN:R03451]
Reaction(KEGG)
Substrate
N6,N6,N6-trimethyl-L-lysine [CPD:C03793];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
(3S)-3-hydroxy-N6,N6,N6-trimethyl-L-lysine [CPD:C01259];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and ascorbate.
History
EC 1.14.11.8 created 1983
Pathway
ec00310  Lysine degradation
Orthology
K00474  trimethyllysine dioxygenase
Genes
HSA: 55217(TMLHE)
PTR: 107966584(TMLHE)
PPS: 100989743(TMLHE)
GGO: 101130045(TMLHE)
PON: 100459640(TMLHE)
NLE: 100595389(TMLHE)
MCC: 703711(TMLHE)
MCF: 102133795(TMLHE)
CSAB: 103232863(TMLHE)
RRO: 104662412(TMLHE)
RBB: 108521721(TMLHE)
CJC: 100396173(TMLHE) 108587670
SBQ: 101039644(TMLHE)
MMU: 192289(Tmlhe)
RNO: 170898(Tmlhe)
CGE: 100757720(Tmlhe)
NGI: 103741300(Tmlhe)
HGL: 101700950(Tmlhe)
CCAN: 109699598(Tmlhe)
OCU: 100338782(TMLHE)
CFA: 481090(TMLHE)
AML: 100484567(TMLHE)
UMR: 103659283(TMLHE)
ORO: 101362600(TMLHE)
FCA: 101094166(TMLHE)
PTG: 102953719(TMLHE)
AJU: 106987211(TMLHE)
BTA: 535630(TMLHE)
BOM: 102265906(TMLHE)
PHD: 102335932(TMLHE)
CHX: 102188121(TMLHE)
OAS: 101106308(TMLHE)
SSC: 100515702(TMLHE)
CFR: 102524405(TMLHE)
CDK: 105089418(TMLHE)
BACU: 103017558(TMLHE)
LVE: 103082632(TMLHE)
OOR: 101287109(TMLHE)
ECB: 100062170(TMLHE)
EPZ: 103541356(TMLHE)
EAI: 106827068(TMLHE)
HAI: 109373621(TMLHE)
RSS: 109437103(TMLHE)
PALE: 102877948(TMLHE)
LAV: 100658531(TMLHE)
TMU: 101360038
MDO: 100024134(TMLHE)
SHR: 100920162(TMLHE) 105751119
OAA: 100084207(TMLHE)
GGA: 422296(TMLHE)
MGP: 100544092(TMLHE)
CJO: 107312861(TMLHE)
APLA: 101794183(TMLHE)
ACYG: 106047518(TMLHE)
TGU: 100230324(TMLHE)
GFR: 102041991(TMLHE)
FAB: 101816366(TMLHE)
PHI: 102099827(TMLHE)
PMAJ: 107204076(TMLHE)
CCAE: 111929269(TMLHE)
CCW: 104691701(TMLHE)
FPG: 101920173(TMLHE)
FCH: 102049828(TMLHE)
CLV: 102085186(TMLHE)
EGZ: 104129538(TMLHE)
AAM: 106489870(TMLHE)
ASN: 102383970(TMLHE)
AMJ: 102558694(TMLHE)
PSS: 102450043(TMLHE)
CMY: 102943917(TMLHE)
CPIC: 101937011(TMLHE)
ACS: 100568254(tmlhe)
PVT: 110084930(TMLHE)
PBI: 103053306(TMLHE)
GJA: 107118207(TMLHE)
XLA: 100189568(tmlhe.L) 399066(tmlhe.S)
XTR: 100124877(tmlhe)
NPR: 108797003(TMLHE)
DRE: 555271(tmlhe)
IPU: 108278764(tmlhe)
AMEX: 103033955(tmlhe)
TRU: 101077347(tmlhe)
LCO: 104920012(tmlhe)
NCC: 104948915
MZE: 101473435(tmlhe)
OLA: 101160186(tmlhe)
XMA: 102235647(tmlhe)
NFU: 107386621(tmlhe)
KMR: 108233816(tmlhe)
CSEM: 103394733(tmlhe)
LCF: 108893980(tmlhe)
SDU: 111222374(tmlhe)
HCQ: 109508849(tmlhe)
BPEC: 110165115(tmlhe)
MALB: 109960422(tmlhe)
SASA: 106563395 106603194(TMLH)
OTW: 112228784 112231363(tmlhe)
ELS: 105024591(tmlhe)
SFM: 108919972(tmlhe)
LCM: 102359408(TMLHE)
CMK: 103177255(tmlhe)
SPU: 584681
SKO: 100375730
DSI: Dsimw501_GD20068(Dsim_GD20068)
AAG: 5572349
NVL: 108557604
BMOR: 101743938
PMAC: 106715682
HAW: 110377408
PXY: 105382967
API: 100168280
DNX: 107167220
ZNE: 110837782
FCD: 110856262
CRG: 105348070
MYI: 110446010
LAK: 106172265
ADF: 107354987
ERC: Ecym_1338
PIC: PICST_46425(TML1)
CAL: CAALFM_C502920WA(CaO19.4316)
CAUR: QG37_02716
NCR: NCU03802(cbs-1)
NTE: NEUTE1DRAFT76877(NEUTE1DRAFT_76877)
MGR: MGG_07454
SSCK: SPSK_02400
MAW: MAC_08951
MAJ: MAA_08416
CMT: CCM_07727
MBE: MBM_01235
ANG: ANI_1_1402164(An18g05220)
ABE: ARB_05432
TVE: TRV_03837
PTE: PTT_08702
CNE: CNF02980
CNB: CNBF1730
SMIN: v1.2.019441.t1(symbB.v1.2.019441.t1)
FCY: FRACYDRAFT_262191(TMLD)
 » show all
Taxonomy
Reference
1  [PMID:627563]
  Authors
Hulse JD, Ellis SR, Henderson LM.
  Title
Carnitine biosynthesis. beta-Hydroxylation of trimethyllysine by an alpha-ketoglutarate-dependent mitochondrial dioxygenase.
  Journal
J Biol Chem 253:1654-9 (1978)
Reference
2  [PMID:27730239]
  Authors
Al Temimi AH, Pieters BJ, Reddy YV, White PB, Mecinovic J
  Title
Substrate scope for trimethyllysine hydroxylase catalysis.
  Journal
Chem Commun (Camb) 52:12849-12852 (2016)
DOI:10.1039/c6cc07845a
Reference
3  [PMID:27965989]
  Authors
Lesniak RK, Markolovic S, Tars K, Schofield CJ
  Title
Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N(epsilon)-trimethyllysine.
  Journal
Chem Commun (Camb) 53:440-442 (2016)
DOI:10.1039/c6cc08381a
Reference
4  [PMID:28045275]
  Authors
Reddy YV, Al Temimi AH, White PB, Mecinovic J
  Title
Evidence That Trimethyllysine Hydroxylase Catalyzes the Formation of (2S,3S)-3-Hydroxy-N(epsilon)-trimethyllysine.
  Journal
Org Lett 19:400-403 (2017)
DOI:10.1021/acs.orglett.6b03608
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.8
IUBMB Enzyme Nomenclature: 1.14.11.8
ExPASy - ENZYME nomenclature database: 1.14.11.8
BRENDA, the Enzyme Database: 1.14.11.8
CAS: 74622-49-4

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