KEGG   ENZYME: 1.14.13.10Help
Entry
EC 1.14.13.10               Enzyme                                 

Name
2,6-dihydroxypyridine 3-monooxygenase;
2,6-dihydroxypyridine oxidase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
2,6-dihydroxypyridine + NADH + H+ + O2 = 2,3,6-trihydroxypyridine + NAD+ + H2O [RN:R04130]
Reaction(KEGG)
Substrate
2,6-dihydroxypyridine [CPD:C03056];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2,3,6-trihydroxypyridine [CPD:C03458];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
A flavoprotein.
History
EC 1.14.13.10 created 1976
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K19189  2,6-dihydroxypyridine 3-monooxygenase
Genes
MSA: Mycsm_00621
MYV: G155_18735
MSM: MSMEG_6489
MSG: MSMEI_6317
MSB: LJ00_32075
MSN: LI99_32080
MSH: LI98_32085
MCB: Mycch_5202
MNE: D174_16010
MGO: AFA91_04745
ROP: ROP_27430
SBH: SBI_01580
SHY: SHJG_1751
NCA: Noca_0592
NML: Namu_4899
STI: Sthe_2312
 » show all
Taxonomy
Reference
1  [PMID:4344227]
  Authors
Holmes PE, Rittenberg SC.
  Title
The bacterial oxidation of nicotine. VII. Partial purification and properties of 2,6-dihydroxypyridine oxidase.
  Journal
J Biol Chem 247:7622-7 (1972)
Reference
2  [PMID:4636328]
  Authors
Holmes PE, Rittenberg SC, Knackmuss HJ.
  Title
The bacterial oxidation of nicotine. 8. Synthesis of 2,3,6-trihydroxypyridine and accumulation and partial characterization of the product of 2,6-dihydroxypyridine oxidation.
  Journal
J Biol Chem 247:7628-33 (1972)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.10
IUBMB Enzyme Nomenclature: 1.14.13.10
ExPASy - ENZYME nomenclature database: 1.14.13.10
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.10
BRENDA, the Enzyme Database: 1.14.13.10
CAS: 39279-38-4

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