KEGG   ENZYME: 1.14.13.114Help
Entry
EC 1.14.13.114              Enzyme                                 

Name
6-hydroxynicotinate 3-monooxygenase;
NicC;
6HNA monooxygenase;
HNA-3-monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating)
Reaction(IUBMB)
6-hydroxynicotinate + NADH + H+ + O2 = 2,5-dihydroxypyridine + NAD+ + H2O + CO2 [RN:R08764]
Reaction(KEGG)
Substrate
6-hydroxynicotinate [CPD:C01020];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2,5-dihydroxypyridine [CPD:C01059];
NAD+ [CPD:C00003];
H2O [CPD:C00001];
CO2 [CPD:C00011]
Comment
A flavoprotein (FAD) [1]. The reaction is involved in the aerobic catabolism of nicotinic acid.
History
EC 1.14.13.114 created 2010
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K14974  6-hydroxynicotinate 3-monooxygenase
Genes
GQU: AWC35_02980
SPE: Spro_2311
SRR: SerAS9_2268
SRL: SOD_c21410(nicC)
SRY: M621_11730
SPLY: Q5A_011865(nicC)
SRS: SerAS12_2268
SRA: SerAS13_2269
SMW: SMWW4_v1c23250
SMAR: SM39_1770
SERF: L085_17120
PPU: PP_3944(nicC)
PPF: Pput_1893
PPB: PPUBIRD1_1864(nahG)
PPI: YSA_08966
PPX: T1E_5123
PPUT: L483_21710
PPUN: PP4_17780
PFS: PFLU_2799
PFB: VO64_0126
PANR: A7J50_2716
PSIL: PMA3_12565
HAM: HALO0543
ADI: B5T_02296
REH: H16_A0922(h16_A0922)
CGD: CR3_3010(nicC)
BCN: Bcen_4324
BCJ: BCAM1146
BCEN: DM39_3876
BCEO: I35_4992
BMU: Bmul_4547
BMK: DM80_3717
BMUL: NP80_4072
BCED: DM42_3945
BCON: NL30_06905
BSEM: WJ12_25625
BPSL: WS57_08400
BMEC: WJ16_24255
BSTG: WT74_20840
BGU: KS03_3918
BGO: BM43_2602
BFN: OI25_6802
PSPU: NA29_11655
BPE: BP1954
BPC: BPTD_1926
BPER: BN118_0960
BPEU: Q425_15000
BPA: BPP2327
BBR: BB1778
BPT: Bpet1330
BAV: BAV1532
AMIM: MIM_c31140
AFQ: AFA_08350
ODI: ODI_R3895
AAV: Aave_3927
AAA: Acav_3824
DAC: Daci_1853
CTES: O987_23175
RLG: Rleg_6042
GXL: H845_1043
APK: APA386B_1213(nahG)
ALI: AZOLI_p20435(nahG)
 » show all
Taxonomy
Reference
1  [PMID:10091591]
  Authors
Nakano H, Wieser M, Hurh B, Kawai T, Yoshida T, Yamane T, Nagasawa T.
  Title
Purification, characterization and gene cloning of 6-hydroxynicotinate 3-monooxygenase from Pseudomonas fluorescens TN5.
  Journal
Eur J Biochem 260:120-6 (1999)
DOI:10.1046/j.1432-1327.1999.00124.x
Reference
2  [PMID:18678916]
  Authors
Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E
  Title
Deciphering the genetic determinants for aerobic nicotinic acid degradation: the  nic cluster from Pseudomonas putida KT2440.
  Journal
Proc Natl Acad Sci U S A 105:11329-34 (2008)
DOI:10.1073/pnas.0802273105
  Sequence
[ppu:PP_3944]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.114
IUBMB Enzyme Nomenclature: 1.14.13.114
ExPASy - ENZYME nomenclature database: 1.14.13.114
BRENDA, the Enzyme Database: 1.14.13.114

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