KEGG   ENZYME: 1.14.13.148Help
Entry
EC 1.14.13.148              Enzyme                                 

Name
trimethylamine monooxygenase;
flavin-containing monooxygenase 3;
FMO3;
tmm (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
N,N,N-trimethylamine,NADPH:oxygen oxidoreductase (N-oxide-forming)
Reaction(IUBMB)
N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O [RN:R05623]
Reaction(KEGG)
Substrate
N,N,N-trimethylamine;
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
N,N,N-trimethylamine N-oxide;
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A flavoprotein. The bacterial enzyme enables bacteria to use trimethylamine as the sole source of carbon and energy [1,4]. The mammalian enzyme is involved in detoxification of trimethylamine. Mutations in the human enzyme cause the inheritable disease known as trimethylaminuria (fish odor syndrome) [2,3].
History
EC 1.14.13.148 created 2012
Pathway
ec00680  Methane metabolism
Orthology
K18277  trimethylamine monooxygenase
Genes
STEK: AXG53_01325
PMY: Pmen_3459
PRE: PCA10_14390
PCQ: PcP3B5_34340(hapE_3)
PPG: PputGB1_2270
PPUT: L483_19090
PPUN: PP4_21860
PFS: PFLU_2331
PFE: PSF113_3540
PMAN: OU5_0413
PSET: THL1_1501
PSIL: PMA3_11125
PHA: PSHAa1699
PTN: PTRA_a2101(tmm)
PNG: PNIG_a2218(tmm)
OCE: GU3_01635
BAV: BAV1821
BTRM: SAMEA390648701700(hapE_2)
HAR: HEAR2456
LCH: Lcho_0154
MXA: MXAN_0506
MLO: mlr7328
AMIH: CO731_04990(hapE_2)
SME: SMc04149
SMER: DU99_00555
SMD: Smed_3315
ARA: Arad_8377
RLE: pRL110548
RLG: Rleg_6584
AZC: AZC_1374
MSL: Msil_3604
SIL: SPO1551(tmm)
RDE: RD1_0632
PAMN: pAMV1p0112(tmm)
CID: P73_0139
SSAN: NX02_15600
GXL: H845_65
MVA: Mvan_1201
MGI: Mflv_5135
MPHL: MPHLCCUG_02553(pamO_2)
MVQ: MYVA_1579
CGL: NCgl1096(Cgl1141)
CGB: cg1292
CGU: WA5_1096
CGT: cgR_1225
CGM: cgp_1292
CGJ: AR0_06205
CEF: CE1213
REQ: REQ_34750
RRT: 4535765_01758(hapE_3)
ARM: ART_3120
NAL: B005_2927
TER: Tery_0516
SMIZ: 4412673_01531(hapE)
MPW: MPR_3295
 » show all
Taxonomy
Reference
1  [PMID:4404764]
  Authors
Large PJ, Boulton CA, Crabbe MJ
  Title
The reduced nicotinamide-adenine dinucleotide phosphate- and oxygen-dependent N-oxygenation of trimethylamine by Pseudomonas aminovorans.
  Journal
Biochem J 128:137P-138P (1972)
Reference
2  [PMID:9417913]
  Authors
Dolphin CT, Riley JH, Smith RL, Shephard EA, Phillips IR
  Title
Structural organization of the human flavin-containing monooxygenase 3 gene (FMO3), the favored candidate for fish-odor syndrome, determined directly from genomic DNA.
  Journal
Genomics 46:260-7 (1997)
DOI:10.1006/geno.1997.5031
  Sequence
[hsa:2328]
Reference
3  [PMID:9536088]
  Authors
Treacy EP, Akerman BR, Chow LM, Youil R, Bibeau C, Lin J, Bruce AG, Knight M, Danks DM, Cashman JR, Forrest SM
  Title
Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication.
  Journal
Hum Mol Genet 7:839-45 (1998)
DOI:10.1093/hmg/7.5.839
  Sequence
[rno:84493]
Reference
4  [PMID:22006322]
  Authors
Chen Y, Patel NA, Crombie A, Scrivens JH, Murrell JC
  Title
Bacterial flavin-containing monooxygenase is trimethylamine monooxygenase.
  Journal
Proc Natl Acad Sci U S A 108:17791-6 (2011)
DOI:10.1073/pnas.1112928108
  Sequence
[msl:Msil_3604]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.148
IUBMB Enzyme Nomenclature: 1.14.13.148
ExPASy - ENZYME nomenclature database: 1.14.13.148
BRENDA, the Enzyme Database: 1.14.13.148

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