KEGG   ENZYME: 1.14.13.24Help
Entry
EC 1.14.13.24               Enzyme                                 

Name
3-hydroxybenzoate 6-monooxygenase;
3-hydroxybenzoate 6-hydroxylase;
m-hydroxybenzoate 6-hydroxylase;
3-hydroxybenzoic acid-6-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating)
Reaction(IUBMB)
3-hydroxybenzoate + NADH + H+ + O2 = 2,5-dihydroxybenzoate + NAD+ + H2O [RN:R02589]
Reaction(KEGG)
Substrate
3-hydroxybenzoate [CPD:C00587];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2,5-dihydroxybenzoate [CPD:C00628];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). Acts also on a number of analogues of 3-hydroxybenzoate substituted in the 2, 4, 5 and 6 positions; NADPH can act instead of NADH, but more slowly.
History
EC 1.14.13.24 created 1984
Pathway
ec00362  Benzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K22270  3-hydroxybenzoate 6-monooxygenase
Genes
ECE: Z3390
ECS: ECs3027
ECF: ECH74115_3267
ETW: ECSP_3013
ELX: CDCO157_2790
ECOO: ECRM13514_5372
ECOH: ECRM13516_3724
EOK: G2583_2678
ELR: ECO55CA74_13240
EAL: EAKF1_ch3857
STY: STY2405
STT: t0680
STM: STM2175
SENI: CY43_11700
SPT: SPA0676
SEK: SSPA0635
SEI: SPC_1527
SEC: SCH_2192(nhg)
SHB: SU5_02767
SENS: Q786_10795
SED: SeD_A2522
SEG: SG2211
SEL: SPUL_0714
SET: SEN2168
SENA: AU38_10960
SENO: AU37_10970
SENV: AU39_10970
SENQ: AU40_12270
SENL: IY59_11265
SEEP: I137_03245
SENE: IA1_10880
SBG: SBG_1987
SBZ: A464_2299
KOX: KOX_25675
KOE: A225_4035
EAE: EAE_23875
EAR: CCG29101
CKO: CKO_00654
CRO: ROD_22631
CAMA: F384_11420
EBF: D782_1486
SMAR: SM39_2826(mhbM)
SMAC: SMDB11_2639(mhbM)
XBV: XBW1_2121(mhbM)
PEN: PSEEN2596(mhbM)
PSEM: TO66_18335
OCE: GU3_03005
PSE: NH8B_2047
REH: H16_B0876(h16_B0876)
CNC: CNE_2c08340(mhbM) CNE_BB2p00890(xlnD)
BCN: Bcen_4218
BCJ: BCAM1274(mhbM)
BCEN: DM39_3727(mhbM)
BCEO: I35_5123(mhbM)
BMU: Bmul_4439
BMJ: BMULJ_04070(nahG)
BMK: DM80_3604(mhbM)
BMUL: NP80_4175(mhbM)
BCT: GEM_4469
BCED: DM42_3818(mhbM)
BCON: NL30_06230
BTEI: WS51_04055
BPSL: WS57_07660
BMEC: WJ16_24850
BGO: BM43_4139(nagX)
PPNO: DA70_13155
PPNM: LV28_17545
PPUL: RO07_11650
PSPU: NA29_07575
PAPI: SG18_11980
BAV: BAV1787
BHZ: ACR54_02471(mhbM)
AXY: AXYL_05897(mhbM)
AXX: ERS451415_00540(mhbM)
POL: Bpro_2128
PNA: Pnap_3144
DAC: Daci_3703
RTA: Rta_17950
LIH: L63ED372_01176(nagX)
HYR: BSY239_3884(nagX)
LCH: Lcho_3669
EBA: ebA1378(s5h)
AZO: azo2422(nahG)
AOA: dqs_2566
TCL: Tchl_1075
MES: Meso_0052
OCH: CES85_5237(xlnD)
RBM: TEF_07880
SIL: SPO3692
JAN: Jann_2908
PGD: Gal_04153
CID: P73_1457
BACO: OXB_0838
BEO: BEH_11950
BKW: BkAM31D_03935(mhbM) BkAM31D_23545(xlnD_2)
SIV: SSIL_3714
SAY: TPY_1281
MAB: MAB_0288
MABB: MASS_0290
MABO: NF82_01455
MCHE: BB28_01425
CGL: NCgl2923(Cgl3026)
CGB: cg3354
CGU: WA5_2923
CGT: cgR_2913
CGM: cgp_3354
CGJ: AR0_14655
CEF: CE2863
ROP: ROP_15470
SALB: XNR_0599
SGU: SGLAU_17245(xlnD1) SGLAU_17380(xlnD2)
STRM: M444_18400
SAMB: SAM23877_1103(mhbM)
SRW: TUE45_05046(xlnD)
STRD: NI25_24455
SALJ: SMD11_3540
KSK: KSE_58270
ART: Arth_2055
AAU: AAur_0334
ACH: Achl_0762
CFI: Celf_3007
 » show all
Taxonomy
Reference
1  [PMID:4357436]
  Authors
Groseclose EE, Ribbons DW, Hughes H.
  Title
3-Hydroxybenzoate 6-hydroxylase from Pseudomonas aeruginosa.
  Journal
Biochem Biophys Res Commun 55:897-903 (1973)
DOI:10.1016/0006-291X(73)91228-X
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.24
IUBMB Enzyme Nomenclature: 1.14.13.24
ExPASy - ENZYME nomenclature database: 1.14.13.24
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.24
BRENDA, the Enzyme Database: 1.14.13.24
CAS: 51570-26-4

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