KEGG   ENZYME: 1.14.13.34Help
Entry
EC 1.14.13.34               Enzyme                                 

Name
leukotriene-E4 20-monooxygenase;
leukotriene-E4 omega-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)
Reaction(IUBMB)
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + H+ + O2 = 20-hydroxyleukotriene E4 + NADP+ + H2O [RN:R04256]
Reaction(KEGG)
Substrate
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate [CPD:C05952];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
20-hydroxyleukotriene E4 [CPD:C03577];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
Also acts on N-acetyl-leukotriene E4, but more slowly. Not identical with EC 1.14.13.30 leukotriene-B4 20-monooxygenase.
History
EC 1.14.13.34 created 1989
Pathway
ec00590  Arachidonic acid metabolism
Reference
1  [PMID:2826163]
  Authors
Orning L.
  Title
Omega-oxidation of cysteine-containing leukotrienes by rat-liver microsomes. Isolation and characterization of omega-hydroxy and omega-carboxy metabolites of leukotriene E4 and N-acetylleukotriene E4.
  Journal
Eur J Biochem 170:77-85 (1987)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.34
IUBMB Enzyme Nomenclature: 1.14.13.34
ExPASy - ENZYME nomenclature database: 1.14.13.34
BRENDA, the Enzyme Database: 1.14.13.34
CAS: 111940-51-3

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