KEGG   ENZYME: 1.14.13.40Help
Entry
EC 1.14.13.40               Enzyme                                 

Name
anthraniloyl-CoA monooxygenase;
anthraniloyl coenzyme A reductase;
2-aminobenzoyl-CoA monooxygenase/reductase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
anthraniloyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing)
Reaction(IUBMB)
anthraniloyl-CoA + 2 NAD(P)H + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NAD(P)+ [RN:R03998 R03999]
Reaction(KEGG)
Substrate
anthraniloyl-CoA [CPD:C02247];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2-amino-5-oxocyclohex-1-enecarboxyl-CoA [CPD:C05165];
H2O [CPD:C00001];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Comment
A flavoprotein (FAD). The non-aromatic product is unstable and releases CO2 and NH3, forming 1,4-cyclohexanedione.
History
EC 1.14.13.40 created 1992
Pathway
ec00627  Aminobenzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K09461  anthraniloyl-CoA monooxygenase
Genes
EBT: EBL_c27870
XDO: XDD1_0582
XHO: A9255_13140
PRG: RB151_004980(namA_1)
PALA: CO695_02395
PHEI: NCTC12003_00494(namA_1)
PFN: HZ99_07200
GAI: IMCC3135_14605(sdgC)
HAM: HALO3237
HCO: LOKO_00703(namA)
RSN: RSPO_m00049(namA)
RPI: Rpic_3831
REH: H16_A2461(abmA)
CNC: CNE_1c23700(abmA) CNE_2c20790(namA2)
RME: Rmet_2202(abmA)
CGD: CR3_1773
BXE: Bxe_B0282
BXB: DR64_5623
BPH: Bphy_4068
BFN: OI25_5793
PPNO: DA70_00035
PPNM: LV28_06240
PPUL: RO07_00230
PSPU: NA29_11405
PAPI: SG18_00525
BPA: BPP3944
BBR: BB4417
BPT: Bpet0549
BAV: BAV3024
BHO: D560_1950
BHZ: ACR54_04143(namA_2)
BTRM: SAMEA390648700754(namA)
AXX: ERS451415_00587(namA_1)
PUT: PT7_3490
AMIM: MIM_c32190
AFQ: AFA_00270
POL: Bpro_0593
PNA: Pnap_3617
AAV: Aave_3180
ACRA: BSY15_1915
VEI: Veis_2872
DAC: Daci_4472
CTES: O987_02010
RTA: Rta_18140
LIM: L103DPR2_00573(namA)
LIH: L63ED372_00049(namA_1)
HYB: Q5W_17685
JAG: GJA_4016
EBA: ebA2164(abmA)
AZO: azo1934(abmA)
AZA: AZKH_1863(abmA)
AOA: dqs_2089
TCL: Tchl_1894
SCL: sce8661
HOH: Hoch_4888
MLO: mll5434
AMIH: CO731_05561(namA_2)
RHT: NT26_3993
OAN: Oant_4014
OAH: DR92_4241
BJA: blr3436
BRA: BRADO2322
BBT: BBta_2683
BRS: S23_21950
AOL: S58_52750
BRAD: BF49_5553
RPE: RPE_3229
AZC: AZC_3190
MNO: Mnod_1202
MAQU: Maq22A_c15065(nemA)
MMED: Mame_00669(namA)
RBM: TEF_16560
SIL: SPOA0407
JAN: Jann_1323
PDE: Pden_5087
PSF: PSE_3147
PGD: Gal_01043
CID: P73_0181
MALG: MALG_04450
SPSE: SULPSESMR1_00933(sdgC)
SPHP: LH20_14085
SGI: SGRAN_0827(namA)
SWI: Swit_0827
SPHD: HY78_22560
SSAN: NX02_11385
SPKC: KC8_08260
BLAS: BSY18_666
MAGX: XM1_3864(yqjM)
MAGN: WV31_20535
TXI: TH3_14060
MID: MIP_00169
MMM: W7S_08110
ROP: ROP_34330
RHB: NY08_2116
RHU: A3Q40_02700(namA_2)
SCO: SCO5980(StBAC16H6.15)
SGR: SGR_1568
SGB: WQO_27505
SFA: Sfla_1378
SBH: SBI_03207
SHY: SHJG_7042
SVE: SVEN_5801
SALS: SLNWT_4232
STRP: F750_5505
SFI: SFUL_5891
SALU: DC74_5977
SALL: SAZ_30965
STRE: GZL_02816
SLD: T261_2068
STRM: M444_26250
SPRI: SPRI_1837
SRW: TUE45_06576(namA_2)
SLE: sle_17320(sle_17320)
STRD: NI25_09500
SMAL: SMALA_0965
SLAU: SLA_5838
SALJ: SMD11_1628
SLX: SLAV_10190(namA1)
SFK: KY5_6122
MTS: MTES_3603
XCE: Xcel_0307
PSIM: KR76_15920
NAL: B005_0467
SEN: SACE_3134
AMD: AMED_8366
AMN: RAM_42960
AMM: AMES_8237
AMZ: B737_8238
AOI: AORI_7153
PSEE: FRP1_17295
PSEH: XF36_18085
SESP: BN6_40630
KAL: KALB_3438
ALL: CRK57982
CAI: Caci_5522
SNA: Snas_0297
RXY: Rxyl_2274
CWO: Cwoe_2161
MRB: Mrub_2111
GAU: GAU_3276
FIN: KQS_01615
 » show all
Taxonomy
Reference
1  [PMID:2591379]
  Authors
Buder R, Fuchs G.
  Title
2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Purification and some properties of the enzyme.
  Journal
Eur J Biochem 185:629-35 (1989)
DOI:10.1111/j.1432-1033.1989.tb15159.x
Reference
2  [PMID:2591380]
  Authors
Buder R, Ziegler K, Fuchs G, Langkau B, Ghisla S.
  Title
2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Studies on the stoichiometry and the course of the reaction.
  Journal
Eur J Biochem 185:637-43 (1989)
DOI:10.1111/j.1432-1033.1989.tb15160.x
Reference
3  [PMID:2384085]
  Authors
Langkau B, Ghisla S, Buder R, Ziegler K, Fuchs G.
  Title
2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Identification of the reaction products.
  Journal
Eur J Biochem 191:365-71 (1990)
DOI:10.1111/j.1432-1033.1990.tb19131.x
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.40
IUBMB Enzyme Nomenclature: 1.14.13.40
ExPASy - ENZYME nomenclature database: 1.14.13.40
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.40
BRENDA, the Enzyme Database: 1.14.13.40
CAS: 112692-57-6

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