KEGG   ENZYME: 1.14.13.61Help
Entry
EC 1.14.13.61               Enzyme                                 

Name
2-hydroxyquinoline 8-monooxygenase;
2-oxo-1,2-dihydroquinoline 8-monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating)
Reaction(IUBMB)
quinolin-2-ol + NADH + H+ + O2 = quinolin-2,8-diol + NAD+ + H2O [RN:R05158]
Reaction(KEGG)
Substrate
quinolin-2-ol [CPD:C06338];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
quinolin-2,8-diol [CPD:C06342];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
Requires iron. Quinolin-2-ol exists largely as the quinolin-2(1H)-one tautomer.
History
EC 1.14.13.61 created 1999
Reference
1  [PMID:7629085]
  Authors
Rosche B, Tshisuaka B, Fetzner S, Lingens F.
  Title
2-Oxo-1,2-dihydroquinoline 8-monooxygenase, a two-component enzyme system from Pseudomonas putida 86.
  Journal
J Biol Chem 270:17836-42 (1995)
DOI:10.1074/jbc.270.30.17836
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.61
IUBMB Enzyme Nomenclature: 1.14.13.61
ExPASy - ENZYME nomenclature database: 1.14.13.61
BRENDA, the Enzyme Database: 1.14.13.61
CAS: 166799-89-9

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