Entry
Name
2-hydroxycyclohexanone 2-monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing)
Reaction(IUBMB)
2-hydroxycyclohexan-1-one + NADPH + H+ + O2 = 6-hydroxyhexan-6-olide + NADP+ + H2O [RN:
R03281 ]
Reaction(KEGG)
Substrate
Product
Comment
The product decomposes spontaneously to 6-oxohexanoic acid (adipic semialdehyde).
History
EC 1.14.13.66 created 1978 as EC 1.14.12.6, transferred 1999 to EC 1.14.13.66
Pathway
Reference
Authors
Davey JF, Trudgill PW.
Title
The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species.
Journal
Other DBs