KEGG   ENZYME: 1.14.14.11Help
Entry
EC 1.14.14.11               Enzyme                                 

Name
styrene monooxygenase;
StyA;
SMO;
NSMOA
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
styrene,FADH2:oxygen oxidoreductase
Reaction(IUBMB)
styrene + FADH2 + O2 = (S)-2-phenyloxirane + FAD + H2O [RN:R05488]
Reaction(KEGG)
Substrate
styrene [CPD:C07083];
FADH2 [CPD:C01352];
O2 [CPD:C00007]
Product
(S)-2-phenyloxirane [CPD:C20782];
FAD [CPD:C00016];
H2O [CPD:C00001]
Comment
The enzyme catalyses the first step in the aerobic styrene degradation pathway. It forms a two-component system with a reductase (StyB) that utilizes NADH to reduce flavin-adenine dinucleotide, which is then transferred to the oxygenase.
History
EC 1.14.14.11 created 2011
Pathway
ec00643  Styrene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14481  styrene monooxygenase
Genes
PSV: PVLB_26557
Taxonomy
Reference
1  [PMID:15292130]
  Authors
Otto K, Hofstetter K, Rothlisberger M, Witholt B, Schmid A
  Title
Biochemical characterization of StyAB from Pseudomonas sp. strain VLB120 as a two-component flavin-diffusible monooxygenase.
  Journal
J Bacteriol 186:5292-302 (2004)
DOI:10.1128/JB.186.16.5292-5302.2004
  Sequence
Reference
2  [PMID:20675468]
  Authors
Tischler D, Kermer R, Groning JA, Kaschabek SR, van Berkel WJ, Schlomann M
  Title
StyA1 and StyA2B from Rhodococcus opacus 1CP: a multifunctional styrene monooxygenase system.
  Journal
J Bacteriol 192:5220-7 (2010)
DOI:10.1128/JB.00723-10
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.11
IUBMB Enzyme Nomenclature: 1.14.14.11
ExPASy - ENZYME nomenclature database: 1.14.14.11
BRENDA, the Enzyme Database: 1.14.14.11

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