KEGG   ENZYME: 1.14.14.8Help
Entry
EC 1.14.14.8                Enzyme                                 

Name
anthranilate 3-monooxygenase (FAD);
anthranilate 3-hydroxylase;
anthranilate hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
anthranilate,FADH2:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
anthranilate + FADH2 + O2 = 3-hydroxyanthranilate + FAD + H2O [RN:R09517]
Reaction(KEGG)
Substrate
anthranilate [CPD:C00108];
FADH2 [CPD:C01352];
O2 [CPD:C00007]
Product
3-hydroxyanthranilate [CPD:C00632];
FAD [CPD:C00016];
H2O [CPD:C00001]
Comment
This enzyme, isolated from the bacterium Geobacillus thermodenitrificans, participates in the pathway of tryptophan degradation. The enzyme is part of a system that also includes a bifunctional riboflavin kinase/FMN adenylyltransferase and an FAD reductase, which ensures ample supply of FAD to the monooxygenase.
History
EC 1.14.14.8 created 2010
Pathway
ec00380  Tryptophan metabolism
Orthology
K16901  anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase
Genes
BCA: BCE_2148
BCX: BCA_2146
BCF: bcf_10170
BCER: BCK_24265
BCEF: BcrFT9_01682
BTL: BALH_1835
BMYC: DJ92_4629
BMQ: BMQ_3596(hpaB)
BMD: BMD_3581(hpaB)
GST: HW35_13010
GTN: GTNG_3160
PDX: Psed_0216
 » show all
Taxonomy
Reference
1  [PMID:19942660]
  Authors
Liu X, Dong Y, Li X, Ren Y, Li Y, Wang W, Wang L, Feng L
  Title
Characterization of the anthranilate degradation pathway in Geobacillus thermodenitrificans NG80-2.
  Journal
Microbiology 156:589-95 (2010)
DOI:10.1099/mic.0.031880-0
  Sequence
[gtn:GTNG_3160]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.8
IUBMB Enzyme Nomenclature: 1.14.14.8
ExPASy - ENZYME nomenclature database: 1.14.14.8
BRENDA, the Enzyme Database: 1.14.14.8

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