KEGG   ENZYME: 1.14.15.11Help
Entry
EC 1.14.15.11               Enzyme                                 

Name
pentalenic acid synthase;
CYP105D7;
sav7469 (gene name);
1-deoxypentalenate,reduced ferredoxin:O2 oxidoreductase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
1-deoxypentalenate,reduced ferredoxin:oxygen oxidoreductase
Reaction(IUBMB)
1-deoxypentalenate + reduced ferredoxin + O2 = pentalenate + oxidized ferredoxin + H2O [RN:R10158]
Reaction(KEGG)
Substrate
1-deoxypentalenate [CPD:C20404];
reduced ferredoxin [CPD:C00138];
O2 [CPD:C00007]
Product
pentalenate [CPD:C20405];
oxidized ferredoxin [CPD:C00139];
H2O [CPD:C00001]
Comment
A heme-thiolate enzyme (P-450). Isolated from the bacterium Streptomyces avermitilis. The product, pentalenate, is a co-metabolite from pentalenolactone biosynthesis.
History
EC 1.14.15.11 created 2012
Pathway
ec00999  Biosynthesis of secondary metabolites - unclassified
Orthology
K17876  pentalenic acid synthase
Genes
NBR: O3I_015060
NTP: CRH09_24060
SCO: SCO0774(3SCF60.06c)
SMA: SAVERM_7469(cyp28)
SGR: SGR_264
SGB: WQO_33270
SCT: SCAT_0296(CYP105D)
SCY: SCATT_03050
SHY: SHJG_8085
SHO: SHJGH_7847
SALS: SLNWT_4127
SFI: SFUL_245
SALU: DC74_6505
SALL: SAZ_33560
SLV: SLIV_34060(cyp105D1)
STRE: GZL_02304
SLD: T261_1672
SLE: cxm22(cxm22)
SNR: SNOUR_10640(cyp105D1)
STRD: NI25_02520
SALJ: SMD11_2051
SFK: KY5_6369c
 » show all
Taxonomy
Reference
1  [PMID:21081950]
  Authors
Takamatsu S, Xu LH, Fushinobu S, Shoun H, Komatsu M, Cane DE, Ikeda H
  Title
Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis.
  Journal
J Antibiot (Tokyo) 64:65-71 (2011)
DOI:10.1038/ja.2010.135
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.15.11
IUBMB Enzyme Nomenclature: 1.14.15.11
ExPASy - ENZYME nomenclature database: 1.14.15.11
BRENDA, the Enzyme Database: 1.14.15.11

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