KEGG   ENZYME: 1.14.15.3Help
Entry
EC 1.14.15.3                Enzyme                                 

Name
alkane 1-monooxygenase;
alkane 1-hydroxylase;
omega-hydroxylase;
fatty acid omega-hydroxylase;
alkane monooxygenase;
1-hydroxylase;
alkane hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
alkane,reduced-rubredoxin:oxygen 1-oxidoreductase
Reaction(IUBMB)
octane + 2 reduced rubredoxin + O2 + 2 H+ = 1-octanol + 2 oxidized rubredoxin + H2O [RN:R02879]
Reaction(KEGG)
Substrate
octane [CPD:C01387];
reduced rubredoxin [CPD:C00340];
O2 [CPD:C00007];
H+ [CPD:C00080]
Product
1-octanol [CPD:C00756];
oxidized rubredoxin [CPD:C00435];
H2O [CPD:C00001]
Comment
Some enzymes in this group are heme-thiolate proteins (P-450). Also hydroxylates fatty acids in the omega-position.
History
EC 1.14.15.3 created 1972
Pathway
ec00071  Fatty acid degradation
ec00590  Arachidonic acid metabolism
ec00930  Caprolactam degradation
Orthology
K00496  alkane 1-monooxygenase
Genes
ENL: A3UG_02310
LNI: CWR52_10205
SRR: SerAS9_1141
SRL: SOD_c10380(alkB1)
SRY: M621_05855
SPLY: Q5A_005825(alkB1)
SRS: SerAS12_1141
SRA: SerAS13_1141
PSD: DSC_08960
DTX: ATSB10_28120
PAE: PA1525(alkB2) PA2574(alkB1)
PAEV: N297_1567(alkB2) N297_2651(alkB1)
PAEI: N296_1567(alkB2) N296_2651(alkB1)
PAU: PA14_30810(alkB1) PA14_44700(alkB2)
PAG: PLES_27201(alkB1) PLES_38031(alkB2)
PAF: PAM18_2419(alkB1) PAM18_3523(alkB2)
PNC: NCGM2_2412(alkB2) NCGM2_3586(alkB1)
PAEB: NCGM1900_3944(alkB1) NCGM1900_5055(alkB2)
PAEU: BN889_01620(alkB2) BN889_02835(alkB1)
PAEC: M802_1564(alkB2) M802_2648(alkB1)
PAEO: M801_1566(alkB2) M801_2516(alkB1)
PMK: MDS_1928
PCQ: PcP3B5_23990(alkB2) PcP3B5_31900(alkB1)
PFL: PFL_2935(alkB)
PPRC: PFLCHA0_c29810(alkB1)
PPRO: PPC_2966(alkB)
PFS: PFLU_3535
PFC: PflA506_2496(alkB)
PFB: VO64_0643
PKC: PKB_2028(alkB2)
PSOS: POS17_2902(alkB)
PANR: A7J50_2574
PSET: THL1_2688
ACB: A1S_1641
ABM: ABSDF1860(alkM)
ABY: ABAYE2014(alkM)
ABN: AB57_1863
ABX: ABK1_2124
ABH: M3Q_2018
ABAD: ABD1_16260(alkM)
ABAZ: P795_9080
ABAU: IX87_19025
ABAA: IX88_10110
ACC: BDGL_001009(alkM)
ACI: ACIAD1411(alkM)
ASJ: AsACE_CH01534(alkB)
MHC: MARHY2735(alkM) MARHY2847(alkB)
MAD: HP15_2574(alkB) HP15_2892(alkB)
MBS: MRBBS_1602(alkB1)
GNI: GNIT_1689
SAGA: M5M_18065
MICC: AUP74_02288(alkB)
LPN: lpg2997
LPH: LPV_3385
LPO: LPO_3336
LPM: LP6_3036
LPF: lpl2925
LPP: lpp3068
LPC: LPC_3312
LPA: lpa_04391
LPE: lp12_2989
LLO: LLO_2382
LHA: LHA_3251(alkB)
LCD: clem_00120(alkB2)
LLG: 44548918_02745(alkB1)
HCH: HCH_04734(alkB)
ABO: ABO_0122(alkB2) ABO_2707(alkB1)
KGE: TQ33_1162
SALN: SALB1_1966
GPB: HDN1F_04190(alkM)
RPI: Rpic_4109
BMA: BMA0635(alkB)
BMV: BMASAVP1_A2377(alkB)
BML: BMA10229_A2910(alkB)
BMN: BMA10247_1692(alkB)
BMAL: DM55_2005
BMAE: DM78_1223
BMAQ: DM76_1980
BMAI: DM57_2646
BMAF: DM51_417
BMAZ: BM44_1494
BMAB: BM45_1057
BPS: BPSL2350
BPL: BURPS1106A_2735(alkB)
BPSE: BDL_3139
BPSM: BBQ_961
BPSU: BBN_1088
BPSD: BBX_1540
BPSH: DR55_2170
BPSA: BBU_3210
BPSO: X996_1814
BUT: X994_86
BTE: BTH_I1814
BTQ: BTQ_2100
BTJ: BTJ_212
BTZ: BTL_1506
BTD: BTI_1284
BTV: BTHA_1610
BTHE: BTN_3269
BTHM: BTRA_1732
BTHA: DR62_39
BTHL: BG87_1719
BOK: DM82_1965
BOC: BG90_2747
BVE: AK36_2960
BCN: Bcen_0501
BCJ: BCAL3029
BCEN: DM39_808
BCEW: DM40_1635
BCEO: I35_0839
BAM: Bamb_0841
BMU: Bmul_2418
BMJ: BMULJ_00816(alkB)
BMK: DM80_719
BMUL: NP80_1069
BCED: DM42_859
BDL: AK34_2200
BCON: NL30_10915
BUB: BW23_760
BLAT: WK25_04595
BTEI: WS51_15120
BSEM: WJ12_04495
BPSL: WS57_22415
BMEC: WJ16_04520
BSTG: WT74_04805
BGU: KS03_3293
BGO: BM43_306
BUK: MYA_0870
BUL: BW21_1432
BXE: Bxe_B1208
BXB: DR64_6524
BFN: OI25_6965
LIH: L63ED372_00180(alkB)
MPT: Mpe_B0606(alkB)
CARE: LT85_p026
PBH: AAW51_0818(alkB1_2)
BBA: Bd2197
BBAT: Bdt_2153
BBAC: EP01_07265
HDN: Hden_0732
RVA: Rvan_1309
MCG: GL4_1311
CAK: Caul_5439
RSP: RSP_1467
PDE: Pden_2098
DSH: Dshi_0027(alkB1)
PSF: PSE_3490(alkB)
PGD: Gal_03414
OAT: OAN307_c47130(alkB1)
OTM: OSB_09520(alkB2_1) OSB_30800(alkB2_2)
PTP: RCA23_c00460(alkB)
SPSE: SULPSESMR1_02992(alkB2) SULPSESMR1_04191(alkB1)
LVS: LOKVESSMR4R_03748(alkB2)
SPHK: SKP52_24510(alkB)
SFLA: SPHFLASMR4Y_00404(alkB1)
ACR: Acry_1262
AMV: ACMV_13020(alkB)
RCE: RC1_0393(alkB)
MTU: Rv3252c(alkB)
MTC: MT3350(alkB)
MRA: MRA_3293(alkB)
MTUR: CFBS_3441(alkB)
MTO: MTCTRI2_3319(alkB)
MTD: UDA_3252c(alkB)
MTN: ERDMAN_3566(alkB)
MTUC: J113_22685
MTUE: J114_17435
MTUL: TBHG_03188
MTUT: HKBT1_3428(alkB)
MTUU: HKBT2_3435(alkB)
MTQ: HKBS1_3438(alkB)
MBO: BQ2027_MB3280C(alkB)
MBB: BCG_3281c(alkB)
MBT: JTY_3277(alkB)
MBM: BCGMEX_3279c(alkB)
MBX: BCGT_3119
MAF: MAF_32630(alkB)
MMIC: RN08_3588
MCE: MCAN_32711(alkB)
MCQ: BN44_70036(alkB)
MCV: BN43_60261(alkB)
MCX: BN42_41302(alkB)
MCZ: BN45_60281(alkB)
MPA: MAP_3364c
MAO: MAP4_0418
MAVI: RC58_01995
MAVU: RE97_02005
MAV: MAV_4215
MIT: OCO_40740
MIA: OCU_40650
MID: MIP_06136
MYO: OEM_41000
MIR: OCQ_42010
MLP: MLM_3375
MUL: MUL_2749(alkB_1)
MMC: Mmcs_1333
MKM: Mkms_1350
MJL: Mjls_1369
MMI: MMAR_1291(alkB) MMAR_3516(alkB_1)
MMAE: MMARE11_12570(alkB) MMARE11_34330(alkB_1)
MMM: W7S_20340
MLI: MULP_01451(alkB) MULP_03769(alkB_1)
MSG: MSMEI_1797(alkB)
MPHL: MPHLCCUG_01637(alkB)
MVQ: MYVA_1486 MYVA_2975(alkB)
MTHN: 4412656_00281(alkB) 4412656_01195(alkB1)
MAB: MAB_3598c
MABB: MASS_3605
MCHE: BB28_18405
MSTE: MSTE_03730
MJD: JDM601_2991(alkB) JDM601_3998(alkB)
MTER: 4434518_02979(alkB_1) 4434518_03945(alkB_2)
CJK: jk1916(alkM)
CVA: CVAR_0139(alkB)
CTER: A606_11475
CGY: CGLY_01080(alkB)
NFR: ERS450000_00739(alkB1_1) ERS450000_05310(alkB) ERS450000_05314(alkB1_2)
NCY: NOCYR_2725(alkB) NOCYR_2826(alkB) NOCYR_4338(alkB) NOCYR_4341(alkA)
RHA: RHA1_ro02534(alkB)
RER: RER_07460(alkB) RER_21620(alkB)
ROP: ROP_22570(alkB) ROP_pROB01-04350(alkB)
REQ: REQ_33430(alkB)
RFA: A3L23_00039(alkB_1) A3L23_01166(alkB_2) A3L23_01600(alkB_3)
RHS: A3Q41_01756(alkB_1) A3Q41_02203(alkB_2) A3Q41_03374(alkB_3)
RHU: A3Q40_00237(alkB) A3Q40_02026(alkB1_1) A3Q40_02998(alkB1_2)
RRT: 4535765_03344(alkB_2) 4535765_04073(alkB1)
GBR: Gbro_4212
GOR: KTR9_2914
TPR: Tpau_2750
SRT: Srot_0768
SALS: SLNWT_0909
LMOI: VV02_18530
NCA: Noca_0122
NDK: I601_1337(alkB)
TCU: Tcur_0560
FAL: FRAAL1986
AMD: AMED_6400
AMN: RAM_32810
AMM: AMES_6308
AMZ: B737_6308
AOI: AORI_4274
PSEA: WY02_07625
PSEE: FRP1_16935
PSEH: XF36_17955
MIL: ML5_4476
ASE: ACPL_4910(alkB)
ACTS: ACWT_4780
CAI: Caci_1373
CWO: Cwoe_5739
FLM: MY04_0667
DDO: I597_0625(alkB2)
MLT: VC82_1335
NDO: DDD_1421
WIN: WPG_1326
KOS: KORDIASMS9_01136(alkB1)
 » show all
Taxonomy
Reference
1  [PMID:4317878]
  Authors
Cardini G, Jurtshuk P.
  Title
The enzymatic hydroxylation of n-octane by Corynebacterium sp. strain 7E1C.
  Journal
J Biol Chem 245:2789-96 (1970)
Reference
2  [PMID:4395379]
  Authors
McKenna EJ, Coon MJ.
  Title
Enzymatic omega-oxidation. IV. Purification and properties of the omega-hydroxylase of Pseudomonas oleovorans.
  Journal
J Biol Chem 245:3882-9 (1970)
Reference
3  [PMID:4294330]
  Authors
Peterson JA, Kusunose M, Kusunose E, Coon MJ.
  Title
Enzymatic omega-oxidation. II. Function of rubredoxin as the electron carrier in omega-hydroxylation.
  Journal
J Biol Chem 242:4334-40 (1967)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.15.3
IUBMB Enzyme Nomenclature: 1.14.15.3
ExPASy - ENZYME nomenclature database: 1.14.15.3
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.15.3
BRENDA, the Enzyme Database: 1.14.15.3
CAS: 9059-16-9

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