KEGG   ENZYME: 1.14.15.5Help
Entry
EC 1.14.15.5                Enzyme                                 

Name
corticosterone 18-monooxygenase;
corticosterone 18-hydroxylase;
corticosterone methyl oxidase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
corticosterone,reduced-adrenodoxin:oxygen oxidoreductase (18-hydroxylating)
Reaction(IUBMB)
corticosterone + 2 reduced adrenodoxin + O2 + 2 H+ = 18-hydroxycorticosterone + 2 oxidized adrenodoxin + H2O [RN:R03262]
Reaction(KEGG)
R03262;
(other) R03263
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Substrate
corticosterone [CPD:C02140];
reduced adrenodoxin [CPD:C00662];
O2 [CPD:C00007];
H+ [CPD:C00080]
Product
18-hydroxycorticosterone [CPD:C01124];
oxidized adrenodoxin [CPD:C00667];
H2O [CPD:C00001]
History
EC 1.14.15.5 created 1972
Pathway
ec00140  Steroid hormone biosynthesis
ec01100  Metabolic pathways
Orthology
K07433  steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
Genes
HSA: 1585(CYP11B2)
PPS: 100971238
MCC: 695914(CYP11B2)
MCF: 102137301
MMU: 110115(Cyp11b1)
RNO: 500892(Cyp11b1)
Taxonomy
Reference
1  [PMID:4381410]
  Authors
Raman PB, Sharma DC, Dorfman RI.
  Title
Studies on aldosterone biosynthesis in vitro.
  Journal
Biochemistry 5:1795-804 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.15.5
IUBMB Enzyme Nomenclature: 1.14.15.5
ExPASy - ENZYME nomenclature database: 1.14.15.5
BRENDA, the Enzyme Database: 1.14.15.5
CAS: 37256-75-0

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