KEGG   ENZYME: 1.14.16.1Help
Entry
EC 1.14.16.1                Enzyme                                 

Name
phenylalanine 4-monooxygenase;
phenylalaninase;
phenylalanine 4-hydroxylase;
phenylalanine hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
Reaction(IUBMB)
L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4a-hydroxytetrahydrobiopterin [RN:R07211]
Reaction(KEGG)
R07211;
(other) R01795
Show
Substrate
L-phenylalanine [CPD:C00079];
tetrahydrobiopterin [CPD:C00272];
O2 [CPD:C00007]
Product
L-tyrosine [CPD:C00082];
4a-hydroxytetrahydrobiopterin [CPD:C15522]
Comment
The active centre contains mononuclear iron(II). The reaction involves an arene oxide that rearranges to give the phenolic hydroxy group. This results in the hydrogen at C-4 migrating to C-3 and in part being retained. This process is known as the NIH-shift. The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7-dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34, 6,7-dihydropteridine reductase, or slowly rearranges into the more stable compound 7,8-dihydrobiopterin.
History
EC 1.14.16.1 created 1961 as EC 1.99.1.2, transferred 1965 to EC 1.14.3.1, transferred 1972 to EC 1.14.16.1, modified 2002, modified 2003
Pathway
ec00360  Phenylalanine metabolism
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec00790  Folate biosynthesis
ec01100  Metabolic pathways
Orthology
K00500  phenylalanine-4-hydroxylase
Genes
HSA: 5053(PAH)
PTR: 741097(PAH)
PPS: 100982303(PAH)
GGO: 101125405(PAH)
PON: 100171844(PAH)
NLE: 100596095(PAH)
MCC: 698696(PAH)
MCF: 102130988(PAH)
CSAB: 103238962(PAH)
RRO: 104657462(PAH)
RBB: 108543127(PAH)
CJC: 100395351(PAH)
SBQ: 101037263(PAH)
MMU: 18478(Pah)
RNO: 24616(Pah)
CGE: 100774376(Pah)
NGI: 103733720(Pah)
HGL: 101705870(Pah)
CCAN: 109697465(Pah)
OCU: 100354678(PAH)
TUP: 102491503(PAH)
CFA: 475446(PAH)
AML: 100473514(PAH)
UMR: 103676494(PAH)
ORO: 101362687(PAH)
FCA: 101081741(PAH)
PTG: 102972479(PAH)
AJU: 106971908(PAH)
BTA: 510583(PAH)
BOM: 102273628(PAH)
BIU: 109559451(PAH)
PHD: 102318189(PAH)
CHX: 102178605(PAH)
OAS: 101110405(PAH)
SSC: 100521900(PAH)
CFR: 102516611(PAH)
CDK: 105097469(PAH)
BACU: 103014510(PAH)
LVE: 103079765(PAH)
OOR: 101269705(PAH)
ECB: 100053361(PAH)
EPZ: 103549362(PAH)
EAI: 106827269(PAH)
MYB: 102251276(PAH)
MYD: 102752111(PAH)
HAI: 109387787(PAH)
RSS: 109447597(PAH)
PALE: 102889914(PAH)
LAV: 100665000(PAH)
TMU: 101340897
MDO: 100021400(PAH)
SHR: 100919346(PAH)
OAA: 100076018(PAH)
GGA: 408024(PAH)
MGP: 100543812(PAH)
CJO: 107316298(PAH)
APLA: 101793775(PAH)
ACYG: 106035810(PAH)
TGU: 100229122(PAH)
GFR: 102032052(PAH)
FAB: 101808898(PAH)
PHI: 102112757(PAH)
PMAJ: 107204609(PAH)
CCAE: 111936097(PAH)
CCW: 104696231
FPG: 101922827(PAH)
FCH: 102060234(PAH)
CLV: 102092338
EGZ: 104135584(PAH)
AAM: 106488436(PAH)
ASN: 102372044(PAH)
AMJ: 102563310(PAH)
PSS: 102454689(PAH)
CMY: 102941454(PAH)
CPIC: 101942952(PAH)
ACS: 100562752(pah)
PVT: 110084785(PAH)
PBI: 103048910(PAH)
GJA: 107119993(PAH)
XLA: 108711027(pah.L) 108713207(pah.S)
XTR: 613076(pah)
NPR: 108789615
DRE: 378962(pah)
SANH: 107695873
SGH: 107587527(pah) 107590936
IPU: 108279870(pah)
AMEX: 103026480(pah)
TRU: 446049(pah)
LCO: 104926294(pah)
NCC: 104945799(pah)
MZE: 101478105(pah)
OLA: 101163702(pah)
XMA: 102221816(pah)
PRET: 103459395(pah)
NFU: 107386776(pah)
KMR: 108233301(pah)
CSEM: 103382571(pah)
LCF: 108897566(pah)
SDU: 111224520(pah)
HCQ: 109530102(pah)
BPEC: 110161446(pah)
MALB: 109967837(pah)
OTW: 112214201(pah) 112217195
ELS: 105030162(pah)
SFM: 108931648(pah)
LCM: 102350205
CMK: 103179867(pah)
CIN: 100181935
SPU: 581035
SKO: 100313702
DME: Dmel_CG7399(Hn)
DER: 6543832
DSI: Dsimw501_GD14035(Dsim_GD14035)
DWI: 6643178
DYA: Dyak_GE21640(Dyak_Hn)
MDE: 101888256
AAG: 23687449
AME: 408622
BIM: 100749265
BTER: 100650566
SOC: 105208034
AEC: 105149428
ACEP: 105627268
HST: 105190713
DQU: 106742584
CFO: 105257274
LHU: 105676062
PGC: 109851997
PCF: 106793909
NVI: 100115984
MDL: 103569754
TCA: 655392
DPA: 109539248
NVL: 108565046
BMOR: 101742825(PAH)
PMAC: 106715940
PRAP: 111003375
HAW: 110379372
PXY: 105388781
API: 100166971
DNX: 107166331
CLEC: 106668455
ZNE: 110827451
FCD: 110853633
CEL: CELE_K08F8.4(pah-1)
CBR: CBG03166(Cbr-pah-1)
TSP: Tsp_08577
MYI: 110459063
OBI: 106880309
LAK: 106163209
ADF: 107340378
HMG: 100197101
PPP: 112285965
MNG: MNEG_4320
DDI: DDB_G0278781(pah)
DFA: DFA_06982(pah)
SMIN: v1.2.028016.t1(symbB.v1.2.028016.t1) v1.2.028017.t1(symbB.v1.2.028017.t1)
TPS: THAPSDRAFT_bd415(PAH1)
NGD: NGA_0605700(PHHA)
LMA: LMJF_28_1280(PAH)
LIF: LINJ_28_1390(PAH)
LBZ: LBRM_28_1380(PAH)
XCC: XCC0156(phhA)
XCB: XC_0165
XCA: xcc-b100_0173(phhA)
XCP: XCR_4381(phhA)
XCV: XCV0157(phhA)
XAX: XACM_0158(phhA)
XAC: XAC0174(pah)
XCI: XCAW_00569(phhA)
XAO: XAC29_00890(phhA)
XOO: XOO0267(pah)
XOM: XOO0243(XOO0243)
XOP: PXO_03285(phhA)
XOR: XOC_0260(phhA)
XAL: XALC_0054(phhA)
XPH: XppCFBP6546_11060(XppCFBP6546P_11060)
SML: Smlt0077(phhA)
SMT: Smal_0032
SMZ: SMD_0029(phhA)
SACZ: AOT14_37130(phhA)
PSUW: WQ53_07765
PSD: DSC_01655(phhA)
LAB: LA76x_0054(phhA)
LAQ: GLA29479_1318(phhA)
LCP: LC55x_0072(phhA)
LGU: LG3211_0066(phhA)
LEZ: GLE_5254(phhA)
LEM: LEN_0064
DKO: I596_3495
VCH: VCA0828(phhA)
VCF: IR04_03610(phhA)
VCS: MS6_A0869
VCE: Vch1786_II0518(phhA)
VCQ: EN18_02465(phhA)
VCI: O3Y_17393(phhA)
VCO: VC0395_0407(phhA)
VCR: VC395_A0852(phhA)
VCM: VCM66_A0787(phhA)
VCX: VAA049_2146(phhA)
VCZ: VAB027_358(phhA)
VVU: VV2_0455(phhA)
VVY: VVA1005
VVL: VV93_v1c39510(phhA)
VPA: VPA0576(phhA)
VPK: M636_02105(phhA)
VPF: M634_23655(phhA)
VCA: M892_24285(phhA)
VAG: N646_4584
VNA: PN96_22475(phhA)
VSP: VS_II1509
VEJ: VEJY3_21801(phhA)
VNI: VIBNI_B1215(phhA)
VAN: VAA_02977
LAG: N175_18040(phhA)
VAU: VANGNB10_cII0203(phhA)
VCY: IX92_21755(phhA)
VCT: JV59_17840(phhA)
VTU: IX91_18100(phhA)
VSC: VSVS12_03581(phhA)
VTA: B1781(phhA)
PPR: PBPRB1164(PP4490)
PAE: PA0872(phhA)
PAEV: N297_900(phhA)
PAEI: N296_900(phhA)
PAU: PA14_52990(phhA)
PAP: PSPA7_4644(phhA)
PAG: PLES_44441(phhA)
PAF: PAM18_4167(phhA)
PNC: NCGM2_1648(phhA)
PAEB: NCGM1900_1852(phhA)
PDK: PADK2_21340(phhA)
PSG: G655_20990(phhA)
PRP: M062_04250(phhA)
PAEP: PA1S_22080(phhA)
PAEM: U769_21450(phhA)
PAEL: T223_22715(phhA)
PAEU: BN889_00906(phhA)
PAEG: AI22_11860(phhA)
PAEC: M802_896(phhA)
PAEO: M801_900(phhA)
PMY: Pmen_3112
PMK: MDS_3411
PRE: PCA10_16580(phhA)
PPSE: BN5_1308(phhA)
PALC: A0T30_14750(phhA)
PCQ: PcP3B5_43910(phhA)
PPU: PP_4490(phhA)
PPF: Pput_1424
PPT: PPS_3835
PPB: PPUBIRD1_1411(phhA)
PPI: YSA_07921
PPX: T1E_4057(phhA)
PPUH: B479_19060(phhA)
PPUT: L483_24525(phhA)
PPUN: PP4_13300(phhA)
PPUD: DW66_4271
PMON: X969_18465(phhA)
PMOT: X970_18100(phhA)
PMOS: O165_015790(phhA)
PST: PSPTO_1822(phhA)
PSB: Psyr_3575(phhA)
PSYR: N018_07545(phhA)
PSP: PSPPH_3531(phhA)
PFL: PFL_1611(phhA)
PPRC: PFLCHA0_c16480(phhA)
PPRO: PPC_1664(phhA)
PFS: PFLU_4458
PFE: PSF113_1529(phhA)
PFC: PflA506_3764(phhA)
PFN: HZ99_25770(phhA)
PFW: PF1751_v1c39510(phhA)
PFF: PFLUOLIPICF716440(phhA)
PPZ: H045_13220(phhA)
PFB: VO64_5077
PMAN: OU5_5116
PTV: AA957_22525(phhA)
PCG: AXG94_23205(phhA)
PAZO: AYR47_28990(phhA)
PEN: PSEEN3892(phhA)
PSA: PST_3562(phhA)
PSZ: PSTAB_3534(phhA)
PSR: PSTAA_3659(phhA)
PSC: A458_03640(phhA)
PSJ: PSJM300_16230(phhA)
PSTU: UIB01_03450(phhA)
PSTT: CH92_04085(phhA)
PBM: CL52_17030(phhA)
PBC: CD58_08095(phhA)
PPUU: PputUW4_03913(phhA)
PDR: H681_17035(phhA)
PSV: PVLB_17595(phhA)
PSK: U771_23210(phhA)
PKC: PKB_3952(phhA)
PCH: EY04_07560(phhA)
PCP: JM49_22310(phhA)
PFZ: AV641_15480(phhA)
PSW: LK03_12185(phhA)
PPV: NJ69_11310(phhA)
PSEM: TO66_07970(phhA)
PSEC: CCOS191_1425(phhA)
PSOS: POS17_1631(phhA)
PKR: AYO71_10395(phhA)
PANR: A7J50_4139
PSET: THL1_1675
PSIL: PMA3_21805(phhA)
AVN: Avin_34650(phhA)
AVL: AvCA_34650(phhA)
AVD: AvCA6_34650(phhA)
ACX: Achr_13760(phhA)
PALI: A3K91_1206
PSYC: DABAL43B_1837(phhA)
PSYA: AOT82_326
SON: SO_1666(phhA)
SDN: Sden_2595
SFR: Sfri_1328
SAZ: Sama_2222
SBL: Sbal_1484
SLO: Shew_1435
SSE: Ssed_2930
SPL: Spea_1448
SHL: Shal_1531
SWD: Swoo_1715
SWP: swp_1650
SVO: SVI_1532(phhA)
SPSW: Sps_03666
ILO: IL0725
ILI: K734_03635(phhA)
CPS: CPS_3766(phhA)
COM: CMT41_13065(phhA)
COZ: A3Q34_03565(phhA)
COLW: A3Q33_02905(phhA)
PHA: PSHAa2043(phhA)
PAT: Patl_2999
PSM: PSM_A2107(phhA)
PSEO: OM33_12855(phhA)
PBW: D172_012710(phhA)
PRR: AT705_16930(phhA)
PTN: PTRA_a2508(phhA)
PLZ: S4054249_16835(phhA)
PEA: PESP_a2663(phhA)
PSPO: PSPO_a2129(phhA)
PART: PARC_a1235(phhA)
PTU: PTUN_a1425(phhA)
PNG: PNIG_a2707(phhA)
PTD: PTET_a2387(phhA)
PSEN: PNC201_11445(phhA)
AMC: MADE_1006175(phhA)
AMH: I633_05855(phhA)
AMAA: amad1_05550(phhA)
AMAL: I607_05330(phhA)
AMAE: I876_05625(phhA)
AMAO: I634_05650(phhA)
AMAD: I636_05560(phhA)
AMAI: I635_05525(phhA)
AMAC: MASE_05135(phhA)
AMB: AMBAS45_05365(phhA)
AMG: AMEC673_05220(phhA)
AMK: AMBLS11_05245(phhA)
ALT: ambt_13010(phhA)
AAL: EP13_05490(phhA)
AAUS: EP12_05560(phhA)
ASQ: AVL57_10695(phhA)
AAW: AVL56_09830(phhA)
ALE: AV939_09710(phhA)
GNI: GNIT_2313(phhA)
GPS: C427_3616(phhA)
LAL: AT746_05795(phhA)
SALH: HMF8227_00842(phhA)
FBL: Fbal_2580
MVS: MVIS_3538(phhA)
SAGA: M5M_12225
MTHD: A3224_07465(phhA)
MICC: AUP74_02685(phhA)
LPN: lpg2647(phhA)
LPH: LPV_2990(phhA)
LPO: LPO_2925(phhA)
LPM: LP6_2678(phhA)
LPF: lpl2572(phhA)
LPP: lpp2700(phhA)
LPC: LPC_0492(phhA)
LPA: lpa_03875
LPE: lp12_2640
LLO: LLO_2654(phhA)
LFA: LFA_2589(phhA)
LHA: LHA_0829(phhA)
LOK: Loa_00825
LCD: clem_10755(phhA)
LLG: 44548918_02009(phhA)
TMC: LMI_2483(phhA)
HCH: HCH_00956(phhA)
HEL: HELO_2254(phhA)
HHU: AR456_08350(phhA)
HCO: LOKO_00072(phhA)
HBE: BEI_2100
KGE: TQ33_0927
AHA: AHA_1883(phhA)
AHY: AHML_10190(phhA)
AHD: AI20_09715(phhA)
AHR: V428_10490(phhA)
AHP: V429_10495(phhA)
AHJ: V469_12905(phhA)
AHH: RY45_10120(phhA)
AHI: VU14_12810(phhA)
ASA: ASA_2420(phhA)
AVR: B565_1620
AVO: AMS64_08000(phhA)
AMED: B224_2628
ASR: WL1483_3766(phhA)
ACAV: VI35_09730
OCE: GU3_14495(phhA)
ZDF: AN401_15125(phhA)
NWE: SAMEA3174300_1883(phhA)
CVI: CV_3180(phhA)
PSE: NH8B_0637
AMAH: DLM_2715
RSO: RSc3355(phhA)
RSC: RCFBP_10110(phhA)
RSL: RPSI07_0089(phhA)
RSN: RSPO_c00086(phhA)
RSM: CMR15_10113(phhA)
RSE: F504_3403
RPI: Rpic_3549
RIN: ACS15_3658(phhA)
REH: H16_A3678(phhA)
CNC: CNE_1c36300(phhA)
RME: Rmet_3533(phhA)
CTI: RALTA_A3134(phhA)
CGD: CR3_2837
BMA: BMA2927(phhA)
BMV: BMASAVP1_A3383(phhA)
BML: BMA10229_A1616(phhA)
BMN: BMA10247_2986(phhA)
BMAL: DM55_963(phhA)
BMAE: DM78_58(phhA)
BMAQ: DM76_938(phhA)
BMAI: DM57_1726
BMAF: DM51_2540(phhA)
BMAZ: BM44_363(phhA)
BMAB: BM45_2977(phhA)
BPS: BPSL3424(phhA)
BPM: BURPS1710b_0206(phhA)
BPL: BURPS1106A_4075(phhA)
BPD: BURPS668_4001(phhA)
BPR: GBP346_A4179(phhA)
BPSE: BDL_1953(phhA)
BPSM: BBQ_3413(phhA)
BPSU: BBN_3534(phhA)
BPSD: BBX_344(phhA)
BPZ: BP1026B_I3716(phhA)
BPK: BBK_1440(phhA)
BPSH: DR55_1081(phhA)
BPSA: BBU_2111(phhA)
BPSO: X996_686(phhA)
BUT: X994_2675(phhA)
BTE: BTH_I3337(phhA)
BTQ: BTQ_11(phhA)
BTJ: BTJ_2434(phhA)
BTZ: BTL_377(phhA)
BTD: BTI_135(phhA)
BTV: BTHA_407(phhA)
BTHE: BTN_1016(phhA)
BTHM: BTRA_551(phhA)
BTHA: DR62_1180
BTHL: BG87_551(phhA)
BOK: DM82_3149(phhA)
BOC: BG90_1586(phhA)
BVE: AK36_679(phhA)
BCN: Bcen_2977
BCJ: BCAL0010(phhA)
BCEN: DM39_3351(phhA)
BCEW: DM40_855(phhA)
BCEO: I35_0012(phhA)
BAM: Bamb_0069
BMU: Bmul_0078
BMJ: BMULJ_03187(pah)
BMK: DM80_1612(phhA)
BMUL: NP80_208(phhA)
BCT: GEM_0073
BCED: DM42_1702(phhA)
BDL: AK34_3008(phhA)
BCON: NL30_19115
BUB: BW23_1631(phhA)
BLAT: WK25_02295
BTEI: WS51_11225
BSEM: WJ12_00430
BPSL: WS57_13380
BMEC: WJ16_00395
BSTG: WT74_00540
BGU: KS03_966(phhA)
BGO: BM43_1459(phhA)
BUK: MYA_0073
BUL: BW21_207(phhA)
BGP: BGL_1c00500(phhA)
BXE: Bxe_A0011
BXB: DR64_2191(phhA)
BFN: OI25_1520(phhA)
PPNO: DA70_16390
PPNM: LV28_14355
PPUL: RO07_08410
PSPU: NA29_04205
PAPI: SG18_08855
PLG: NCTC10937_03882(phhA)
AKA: TKWG_18190(phhA)
AMIM: MIM_c10430(phhA)
PNA: Pnap_1117
AAV: Aave_4193
AJS: Ajs_0518
AAA: Acav_4063
ACK: C380_02955(phhA)
ACRA: BSY15_2010(phhA)
VEI: Veis_2136
DAC: Daci_1267
VPD: VAPA_1c49240(phhA)
CTES: O987_25290
RTA: Rta_05490(phhA)
HYR: BSY239_3652(phhA)
HYB: Q5W_20365
MPT: Mpe_A0347
HSE: Hsero_4280(phhA)
HRB: Hrubri_4203(phhA)
CFU: CFU_4019(pah)
CARE: LT85_4572
CPRA: CPter91_5005(phhA)
LCH: Lcho_2046
TIN: Tint_1003
THI: THI_1261(phhA)
RGE: RGE_43970(phhA)
RBN: RBXJA2T_01665(phhA)
PBH: AAW51_4751(phhA)
ADE: Adeh_2800
MXA: MXAN_5127
CCX: COCOR_04907(phhA)
SCL: sce5266(phhA)
BBA: Bd3537
BBAT: Bdt_3444(phhA)
BBW: BDW_13045
BBAC: EP01_02870
BEX: A11Q_2247
BSTO: C0V70_13310(phhA)
RBE: RBE_1408
RBO: A1I_07840(phhA)
MLO: mlr4831
AMIH: CO731_05212(phhA)
ARA: Arad_8207(phhA)
RET: RHE_CH01742(phhA)
REC: RHECIAT_CH0001823(phhA)
REL: REMIM1_CH01782(phhA)
REP: IE4803_CH01762(phhA)
REI: IE4771_CH01814(phhA)
RLE: RL1860(phhA)
RLG: Rleg_1507
RGA: RGR602_CH01436(phhA)
RHN: AMJ98_CH01785(phhA)
RPHA: AMC79_CH01796(phhA)
RHX: AMK02_CH01795(phhA)
RHK: Kim5_CH01881(phhA)
REZ: AMJ99_CH01864(phhA)
NGL: RG1141_CH11310(forM)
NGG: RG540_CH11610(forM)
MSC: BN69_0991
BRN: D1F64_18590(phhA)
RBM: TEF_11500
CCR: CC_1612(phhA)
CAK: Caul_2208
CSE: Cseg_2596
PZU: PHZ_c1409(phhA)
PARO: CUV01_10040(phhA)
MALG: MALG_01429
HAT: RC74_19475(phhA)
HNE: HNE_1395(phhA)
HBA: Hbal_2665
NAR: Saro_3187
SPHK: SKP52_06925(phhA1) SKP52_17450(phhA2)
SGI: SGRAN_3375(phhA)
SPHU: SPPYR_0265(phhA) SPPYR_0716(phhA) SPPYR_2260(phhA)
SPHM: G432_16830(phhA)
STAX: MC45_11045
SPHI: TS85_12360
SSAN: NX02_24435
SPKC: KC8_17825
SSY: SLG_11900(phhA)
SPMI: K663_18546(phhA)
SPHB: EP837_03613(phhA)
SPHR: BSY17_2877(phhA)
SINB: SIDU_18130
SPHT: K426_21344(phhA) K426_22644(phhA)
SFLA: SPHFLASMR4Y_00604(phhA)
BLAS: BSY18_1779(phhA)
ELI: ELI_12050
AAY: WYH_02096(phhA)
ANH: A6F65_00613(phhA)
ADO: A6F68_00322(phhA)
ALB: AEB_P0328
RCE: RC1_3346(phhA)
TMO: TMO_0657(phhA)
TXI: TH3_18080
MAI: MICA_271(phhA)
MAN: A11S_269
BAN: BA_4586
BAR: GBAA_4586
BAT: BAS4253(phhA)
BAI: BAA_4605
BANT: A16_45830
BANR: A16R_46400
BANS: BAPAT_4401
BANV: DJ46_3262
BCE: BC4352(phhA)
BCA: BCE_4439
BCZ: BCE33L4102(pah)
BCQ: BCQ_4142(pah)
BCX: BCA_4470
BAL: BACI_c43440(pah)
BNC: BCN_4268
BCF: bcf_21675
BCER: BCK_13410
BTK: BT9727_4091(phhA)
BTL: BALH_3943(pah)
BTT: HD73_4665
BTHI: BTK_22980
BTM: MC28_3648
BTI: BTG_27295
BTW: BF38_112
BWW: bwei_0581(pah)
BMYO: BG05_1668
BMYC: DJ92_1455
ESI: Exig_1060
EAN: Eab7_1032
ASOC: CB4_01977(phhA)
NFA: NFA_9410
NFR: ERS450000_03175(phhA)
NCY: NOCYR_1007(phhA)
NBR: O3I_005335(phhA)
NSR: NS506_07361(phhA)
SALU: DC74_6987
SALL: SAZ_36265
SLD: T261_3868
SRW: TUE45_01125(phhA)
STRD: NI25_00525
SALJ: SMD11_3172
SFK: KY5_0293
BCV: Bcav_3578
CFI: Celf_2069
MPH: MLP_36500
PSIM: KR76_09690
TCU: Tcur_3717
SRO: Sros_8337
SESP: BN6_28610
TBI: Tbis_1027
GLJ: GKIL_3071(phhA)
CAU: Caur_2799
CAG: Cagg_0605
HAU: Haur_3847
CHB: G5O_0748
CHR: Cpsi_6981
CPSN: B712_0765
CPSB: B595_0821(pah)
CPSG: B598_0761
CPSM: B602_0766(pah)
CPSV: B600_0818(pah)
CPSW: B603_0769(pah)
CPST: B601_0762
CPSA: AO9_03660(phhA)
CABO: AB7_7581
GES: VT84_32625(phhA)
ACA: ACP_3318(phhA)
ABAS: ACPOL_6655
SUS: Acid_4098
ABAC: LuPra_03168(phhA)
SRU: SRU_2069(phhA)
SRM: SRM_02286(phhA)
SGN: SGRA_1091(phhA)
PHE: Phep_3273
SMIZ: 4412673_02783(phhA)
MUC: MuYL_3650
MGOT: MgSA37_01599(phhA)
CHU: CHU_3025(phhA)
DFE: Dfer_2108
SLI: Slin_6319
SPIR: CWM47_23440(phhA)
LBY: Lbys_0242
RUN: DR864_00630(phhA)
RUP: DTQ70_05500(phhA)
FAE: FAES_1109
FLM: MY04_1170
GFO: GFO_0233(phhA)
GFL: GRFL_2022
FJO: Fjoh_1902
FJG: BB050_00701(phhA)
FPS: FP1954(phhA)
FIN: KQS_10995(phhA)
ZPR: ZPR_0791
MARM: YQ22_04765
CBAL: M667_01885
CBAT: M666_01905
DOK: MED134_11651(phhA)
DDO: I597_1100(phhA)
ZGA: ZOBELLIA_969(phhA)
MLT: VC82_893
NDO: DDD_0620(phhA)
MYR: MYRA21_0731(phhA)
MPW: MPR_3254
TJE: TJEJU_0591(phhA)
TMAR: MARIT_0418(phhA)
AALG: AREALGSMS7_00527(phhA)
SPON: HME9304_00933(phhA)
KOS: KORDIASMS9_00285(phhA)
MARF: CJ739_2242
FBU: UJ101_01498(phhA|PAH)
IAL: IALB_1335(phhA)
 » show all
Taxonomy
Reference
1  [PMID:5773277]
  Authors
Guroff G, Rhoads CA.
  Title
Phenylalanine hydroxylation by Pseudomonas species (ATCC 11299a). Nature of the cofactor.
  Journal
J Biol Chem 244:142-6 (1969)
Reference
2  [PMID:14404870]
  Authors
KAUFMAN S.
  Title
Studies on the mechanism of the enzymatic conversion of phenylalanine to tyrosine.
  Journal
J Biol Chem 234:2677-82 (1959)
Reference
3  [PMID:13292928]
  Authors
MITOMA C.
  Title
Studies on partially purified phenylalanine hydroxylase.
  Journal
Arch Biochem Biophys 60:476-84 (1956)
DOI:10.1016/0003-9861(56)90453-2
Reference
4  [PMID:14927641]
  Authors
UDENFRIEND S, COOPER JR.
  Title
The enzymatic conversion of phenylalanine to tyrosine.
  Journal
J Biol Chem 194:503-11 (1952)
Reference
5  [PMID:7779797]
  Authors
Carr RT, Balasubramanian S, Hawkins PC, Benkovic SJ.
  Title
Mechanism of metal-independent hydroxylation by Chromobacterium violaceum phenylalanine hydroxylase.
  Journal
Biochemistry 34:7525-32 (1995)
Reference
6  [PMID:11718561]
  Authors
Andersen OA, Flatmark T, Hough E.
  Title
High resolution crystal structures of the catalytic domain of human phenylalanine hydroxylase in its catalytically active Fe(II) form and binary complex with tetrahydrobiopterin.
  Journal
J Mol Biol 314:279-91 (2001)
DOI:10.1006/jmbi.2001.5061
  Sequence
[hsa:5053]
Reference
7  [PMID:12096915]
  Authors
Erlandsen H, Kim JY, Patch MG, Han A, Volner A, Abu-Omar MM, Stevens RC.
  Title
Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates.
  Journal
J Mol Biol 320:645-61 (2002)
DOI:10.1016/S0022-2836(02)00496-5
  Sequence
[cvi:CV_3180]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.16.1
IUBMB Enzyme Nomenclature: 1.14.16.1
ExPASy - ENZYME nomenclature database: 1.14.16.1
BRENDA, the Enzyme Database: 1.14.16.1
CAS: 9029-73-6

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