KEGG   ENZYME: 1.14.16.3Help
Entry
EC 1.14.16.3                Enzyme                                 

Name
anthranilate 3-monooxygenase;
anthranilate 3-hydroxylase;
anthranilate hydroxylase;
anthranilic hydroxylase;
anthranilic acid hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
anthranilate,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
anthranilate + tetrahydrobiopterin + O2 = 3-hydroxyanthranilate + dihydrobiopterin + H2O [RN:R01816]
Reaction(KEGG)
Substrate
anthranilate [CPD:C00108];
tetrahydrobiopterin [CPD:C00272];
O2 [CPD:C00007]
Product
3-hydroxyanthranilate [CPD:C00632];
dihydrobiopterin [CPD:C00268];
H2O [CPD:C00001]
Comment
Requires Fe2+.
History
EC 1.14.16.3 created 1972
Pathway
ec00380  Tryptophan metabolism
Reference
1  [PMID:5789774]
  Authors
Jequier E, Robinson DS, Lovenberg W, Sjoerdsma A.
  Title
Further studies on tryptophan hydroxylase in rat brainstem and beef pineal.
  Journal
Biochem Pharmacol 18:1071-81 (1969)
DOI:10.1016/0006-2952(69)90111-7
Reference
2
  Authors
Nair, P.M. and Vaidyanathan, C.S.
  Title
Anthranilic acid hydroxylase from Tecoma stans.
  Journal
Biochim Biophys Acta 110:521-531 (1965)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.16.3
IUBMB Enzyme Nomenclature: 1.14.16.3
ExPASy - ENZYME nomenclature database: 1.14.16.3
BRENDA, the Enzyme Database: 1.14.16.3
CAS: 37256-79-4

DBGET integrated database retrieval system