KEGG   ENZYME: 1.14.17.4Help
Entry
EC 1.14.17.4                Enzyme                                 

Name
aminocyclopropanecarboxylate oxidase;
ACC oxidase;
ethylene-forming enzyme;
1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
1-aminocyclopropane-1-carboxylate oxygenase (ethene-forming)
Reaction(IUBMB)
1-aminocyclopropane-1-carboxylate + ascorbate + O2 = ethene + cyanide + dehydroascorbate + CO2 + 2 H2O [RN:R07214]
Reaction(KEGG)
Substrate
1-aminocyclopropane-1-carboxylate [CPD:C01234];
ascorbate [CPD:C00072];
O2 [CPD:C00007]
Product
ethene [CPD:C06547];
cyanide [CPD:C00177];
dehydroascorbate [CPD:C05422];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
A nonheme iron enzyme. Requires CO2 for activity. In the enzyme from plants, the ethene has signalling functions such as stimulation of fruit-ripening.
History
EC 1.14.17.4 created 2003
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K05933  aminocyclopropanecarboxylate oxidase
Genes
RSS: 109442151 109442718
ATH: AT1G05010(EFE) AT1G12010 AT1G62380(ACO2) AT1G77330 AT2G19590(ACO1)
ALY: ARALYDRAFT_343239 ARALYDRAFT_475105 ARALYDRAFT_476898 ARALYDRAFT_674350 ARALYDRAFT_678892 ARALYDRAFT_887679
CRB: 17890827 17895320 17896063 17897371 17898510
CSAT: 104702510 104702691 104703842 104713401 104714576 104739032 104751628 104752897 104754646 104755464 104762852 104766879 104770859 104773072
EUS: EUTSA_v10002047mg EUTSA_v10008207mg EUTSA_v10008225mg EUTSA_v10018919mg EUTSA_v10023595mg
BRP: 103828296(ACO1) 103830571 103832184 103838399(acoii) 103842633 103843208 103844184 103848186 103853067 103872037(acoi)
BNA: 106349119 106353485 106365298 106365779 106366841 106374519 106376208 106376249 106385998 106390528 106397796 106400855 106401155 106401189 106407006 106412278 106412394 106422042 106423689 106436068 106450750 111200995 111210370 111213114
BOE: 106292830 106295480 106298654 106309653 106311615 106319188 106321415 106325048 106339340
THJ: 104801008 104801879 104809474 104812086 104818598
LJA: Lj0g3v0109219.1(Lj0g3v0109219.1) Lj0g3v0109219.2(Lj0g3v0109219.2) Lj1g3v0884400.1(Lj1g3v0884400.1) Lj2g3v0911850.1(Lj2g3v0911850.1) Lj2g3v0911860.1(Lj2g3v0911860.1) Lj2g3v2879460.1(Lj2g3v2879460.1) Lj4g3v0120430.1(Lj4g3v0120430.1) Lj6g3v1789900.1(Lj6g3v1789900.1)
CSV: 101203726 101204103(Cs-ACO2) 101209525(CS-ACO1) 101221460 101221653(CS-ACO2)
VVI: 100232928(ACO1) 100252394 100256784(ACO2) 100257676(ACO3)
SLY: 100125909 101251255(ACO2) 101266529 543506 543800(aco5) 544052(ACO1) 544285(ACO4)
DOSA: Os01t0580500-01(Os01g0580500) Os02t0771600-01(Os02g0771600) Os05t0149300-00(Os05g0149300) Os05t0149400-01(Os05g0149400) Os06t0573900-00(Os06g0573900) Os09t0451000-01(Os09g0451000) Os09t0451400-01(Os09g0451400) Os11t0186900-01(Os11g0186900)
ATS: 109735112(LOC109735112) 109739668(LOC109739668) 109746094(LOC109746094) 109752652(LOC109752652) 109754988(LOC109754988) 109754989(LOC109754989) 109770324(LOC109770324) 109772806(LOC109772806)
 » show all
Taxonomy
Reference
1  [PMID:7717997]
  Authors
Zhang Z, Schofield CJ, Baldwin JE, Thomas P, John P.
  Title
Expression, purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from tomato in Escherichia coli.
  Journal
Biochem J 307 ( Pt 1):77-85 (1995)
Reference
2  [PMID:9398335]
  Authors
Zhang Z, Barlow JN, Baldwin JE, Schofield CJ.
  Title
Metal-catalyzed oxidation and mutagenesis studies on the iron(II) binding site of 1-aminocyclopropane-1-carboxylate oxidase.
  Journal
Biochemistry 36:15999-6007 (1997)
DOI:10.1021/bi971823c
Reference
3
  Authors
Pirrung, M.C.
  Title
Ethylene biosynthesis from 1-aminocyclopropanecarboxylic acid.
  Journal
Acc Chem Res 32:711-718 (1999)
Reference
4  [PMID:11361015]
  Authors
Charng YY, Chou SJ, Jiaang WT, Chen ST, Yang SF.
  Title
The catalytic mechanism of 1-aminocyclopropane-1-carboxylic acid oxidase.
  Journal
Arch Biochem Biophys 385:179-85 (2001)
DOI:10.1006/abbi.2000.2138
Reference
5  [PMID:11583172]
  Authors
Thrower JS, Blalock R 3rd, Klinman JP.
  Title
Steady-state kinetics of substrate binding and iron release in tomato ACC oxidase.
  Journal
Biochemistry 40:9717-24 (2001)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.17.4
IUBMB Enzyme Nomenclature: 1.14.17.4
ExPASy - ENZYME nomenclature database: 1.14.17.4
BRENDA, the Enzyme Database: 1.14.17.4
CAS: 98668-53-2

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