KEGG   ENZYME: 1.14.18.3Help
Entry
EC 1.14.18.3                Enzyme                                 

Name
methane monooxygenase (particulate)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With another compound as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
methane,quinol:oxygen oxidoreductase
Reaction(IUBMB)
methane + quinol + O2 = methanol + quinone + H2O [RN:R09518]
Reaction(KEGG)
Substrate
methane [CPD:C01438];
quinol [CPD:C15603];
O2 [CPD:C00007]
Product
methanol [CPD:C00132];
quinone [CPD:C15602];
H2O [CPD:C00001]
Comment
Contains copper. It is membrane-bound, in contrast to the soluble methane monooxygenase (EC 1.14.13.25).
History
EC 1.14.18.3 created 2011
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
Orthology
K10944  methane/ammonia monooxygenase subunit A
Genes
MCA: MCA1797(pmoA) MCA2854(pmoA2)
MMT: Metme_0304
MDN: JT25_004545 JT25_012445
MDH: AYM39_18580 AYM39_19770
MKO: MKLM6_3758 MKLM6_3997
MAH: MEALZ_0515(pmoA)
MPSY: CEK71_17435
NOC: Noc_2502
NHL: Nhal_0676
NWA: Nwat_0632
NTT: TAO_1521(amoA)
NEU: NE0944(amoA1) NE2063(amoA2)
MSC: BN69_0203(pmoA2) BN69_2827(pmoA) BN69_3534(pmoA)
MIN: Minf_1507(pmoA) Minf_1510(pmoA) Minf_1590(pmoA)
NIO: NITINOP_1853(amoA)
MOX: DAMO_2450(pmoA)
NMR: Nmar_1500
NID: NPIRD3C_2147(amoA)
NIN: NADRNF5_0394(amoA)
NCT: NMSP_0259
NGA: Ngar_c25350(amoA)
NVN: NVIE_027270(amoA)
NEV: NTE_00961
NCV: NCAV_0492(amoA)
NBV: T478_0302
NDV: NDEV_1777(amoA)
 » show all
Taxonomy
Reference
1  [PMID:7646068]
  Authors
Shiemke AK, Cook SA, Miley T, Singleton P
  Title
Detergent solubilization of membrane-bound methane monooxygenase requires plastoquinol analogs as electron donors.
  Journal
Arch Biochem Biophys 321:421-8 (1995)
DOI:10.1006/abbi.1995.1413
  Sequence
Reference
2  [PMID:12379148]
  Authors
Basu P, Katterle B, Andersson KK, Dalton H
  Title
The membrane-associated form of methane mono-oxygenase from Methylococcus capsulatus (Bath) is a copper/iron protein.
  Journal
Biochem J 369:417-27 (2003)
DOI:10.1042/BJ20020823
  Sequence
Reference
3  [PMID:16101279]
  Authors
Kitmitto A, Myronova N, Basu P, Dalton H
  Title
Characterization and structural analysis of an active particulate methane monooxygenase trimer from Methylococcus capsulatus (Bath).
  Journal
Biochemistry 44:10954-65 (2005)
DOI:10.1021/bi050820u
  Sequence
Reference
4  [PMID:17444606]
  Authors
Balasubramanian R, Rosenzweig AC
  Title
Structural and mechanistic insights into methane oxidation by particulate methane monooxygenase.
  Journal
Acc Chem Res 40:573-80 (2007)
DOI:10.1021/ar700004s
Other DBs
ExplorEnz - The Enzyme Database: 1.14.18.3
IUBMB Enzyme Nomenclature: 1.14.18.3
ExPASy - ENZYME nomenclature database: 1.14.18.3
BRENDA, the Enzyme Database: 1.14.18.3

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