KEGG   ENZYME: 1.14.99.44Help
Entry
EC 1.14.99.44               Enzyme                                 

Name
diapolycopene oxygenase;
crtP (ambiguous)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
BRITE hierarchy
Sysname
4,4'-diapolycopene,AH2:oxygen oxidoreductase (4,4'-hydroxylating)
Reaction(IUBMB)
4,4'-diapolycopene + 4 reduced acceptor + 4 O2 = 4,4'-diapolycopenedial + 4 acceptor + 6 H2O [RN:R09671]
Reaction(KEGG)
Substrate
4,4'-diapolycopene [CPD:C19797];
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]
Product
4,4'-diapolycopenedial [CPD:C19798];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Comment
Little activity with neurosporene or lycopene. Involved in the biosynthesis of C30 carotenoids such as staphyloxanthin. The enzyme oxidizes each methyl group to the hydroxymethyl and then a dihydroxymethyl group, followed by the spontaneous loss of water to give an aldehyde group.
History
EC 1.14.99.44 created 2011
Pathway
ec00906  Carotenoid biosynthesis
Orthology
K10210  diapolycopene oxygenase
Genes
MMT: Metme_3774
MDN: JT25_002365
MDH: AYM39_15930
MKO: MKLM6_3290
MPSY: CEK71_14805
BMH: BMWSH_3257 BMWSH_3258(crtI)
BMEG: BG04_4322(crtP)
BIF: N288_02870
BLE: BleG1_3942
BWH: A9C19_17020
BBEV: BBEV_0577(crtP-1)
OIH: OB2459
SAU: SA2351
SAV: SAV2564
SAW: SAHV_2548
SAM: MW2485
SAS: SAS2450
SAR: SAR2646
SAC: SACOL2579
SAE: NWMN_2464(crtI)
SAD: SAAV_2630
SUJ: SAA6159_02460(crtI)
SUK: SAA6008_02603(crtI)
SUC: ECTR2_2417(crtI)
SUQ: HMPREF0772_10625(crtI)
SUZ: MS7_2571(crtP)
SUG: SAPIG2615
SAUA: SAAG_00385
SAUS: SA40_2318
SAUU: SA957_2402
SAUG: SA268_2480
SAUV: SAI7S6_1019090(crtP)
SAUW: SAI5S5_1019030(crtP)
SAUX: SAI6T6_1019040(crtP)
SAUY: SAI8T7_1019070(crtP)
SAUF: X998_2547
SAB: SAB2437c
SAUB: C248_2622
SAUC: CA347_2640(crtP)
SAUR: SABB_01120(crtP)
SAUI: AZ30_13435
SAUD: CH52_06180
SAMS: NI36_12830
SHA: SH0488
SHH: ShL2_00389(crtI)
SXO: SXYL_00051(crtP)
SCAP: AYP1020_1735(crtP)
PSWU: SY83_16585
SIV: SSIL_3759
JEO: JMA_07510
SPOS: DV702_13350(crtI)
ECAS: ECBG_01335
EMU: EMQU_0489
CRN: CAR_c19220(crtP)
JDA: BW727_102018(crtP)
 » show all
Taxonomy
Reference
1  [PMID:15850982]
  Authors
Mijts BN, Lee PC, Schmidt-Dannert C
  Title
Identification of a carotenoid oxygenase synthesizing acyclic xanthophylls: combinatorial biosynthesis and directed evolution.
  Journal
Chem Biol 12:453-60 (2005)
DOI:10.1016/j.chembiol.2005.02.010
  Sequence
[sav:SAV2564]
Reference
2  [PMID:15933032]
  Authors
Tao L, Schenzle A, Odom JM, Cheng Q
  Title
Novel carotenoid oxidase involved in biosynthesis of 4,4'-diapolycopene dialdehyde.
  Journal
Appl Environ Microbiol 71:3294-301 (2005)
DOI:10.1128/AEM.71.6.3294-3301.2005
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.44
IUBMB Enzyme Nomenclature: 1.14.99.44
ExPASy - ENZYME nomenclature database: 1.14.99.44
BRENDA, the Enzyme Database: 1.14.99.44

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