KEGG   ENZYME: 1.16.1.5Help
Entry
EC 1.16.1.5                 Enzyme                                 

Name
aquacobalamin reductase (NADPH);
aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) reductase;
NADPH-linked aquacobalamin reductase;
NADPH2:aquacob(III)alamin oxidoreductase
Class
Oxidoreductases;
Oxidizing metal ions;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
cob(II)alamin:NADP+ oxidoreductase
Reaction(IUBMB)
2 cob(II)alamin + NADP+ + 2 H2O = 2 aquacob(III)alamin + NADPH + H+ [RN:R00107]
Reaction(KEGG)
Substrate
cob(II)alamin [CPD:C00541];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
aquacob(III)alamin [CPD:C00992];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
A flavoprotein. Acts on aquacob(III)alamin and hydroxycobalamin, but not on cyanocobalamin.
History
EC 1.16.1.5 created 1989 as EC 1.6.99.11, transferred 2002 to EC 1.16.1.5
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01100  Metabolic pathways
Orthology
K21682  pyruvate dehydrogenase (NADP+) / aquacobalamin reductase (NADPH)
Genes
CPV: cgd4_690
SMIN: v1.2.029520.t1(symbB.v1.2.029520.t1) v1.2.029521.t1(symbB.v1.2.029521.t1)
GTT: GUITHDRAFT_159505
Taxonomy
Reference
1  [PMID:3114247]
  Authors
Watanabe F, Oki Y, Nakano Y, Kitaoka S.
  Title
Purification and characterization of aquacobalamin reductase (NADPH) from Euglena gracilis.
  Journal
J Biol Chem 262:11514-8 (1987)
Reference
2  [PMID:8373179]
  Authors
Watanabe F, Yamaji R, Isegawa Y, Yamamoto T, Tamura Y, Nakano Y.
  Title
Characterization of aquacobalamin reductase (NADPH) from Euglena gracilis.
  Journal
Arch Biochem Biophys 305:421-7 (1993)
DOI:10.1006/abbi.1993.1441
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.16.1.5
IUBMB Enzyme Nomenclature: 1.16.1.5
ExPASy - ENZYME nomenclature database: 1.16.1.5
BRENDA, the Enzyme Database: 1.16.1.5
CAS: 110777-32-7

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