KEGG   ENZYME: 1.16.8.1Help
Entry
EC 1.16.8.1                 Enzyme                                 

Name
cob(II)yrinic acid a,c-diamide reductase;
cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase (incorrect)
Class
Oxidoreductases;
Oxidizing metal ions;
With a flavin as acceptor
BRITE hierarchy
Sysname
cob(I)yrinic acid-a,c-diamide:FMN oxidoreductase
Reaction(IUBMB)
2 cob(I)yrinic acid a,c-diamide + FMN + 2 H+ = 2 cob(II)yrinic acid a,c-diamide + FMNH2 [RN:R05218]
Reaction(KEGG)
Substrate
cob(I)yrinic acid a,c-diamide [CPD:C06505];
FMN [CPD:C00061];
H+ [CPD:C00080]
Product
cob(II)yrinic acid a,c-diamide [CPD:C06504];
FMNH2 [CPD:C01847]
Comment
This enzyme also catalyses the reduction of cob(II)yric acid, cob(II)inamide, cob(II)inamide phosphate, GDP-cob(II)inamide and cob(II)alamin although cob(II)yrinic acid a,c-diamide is thought to be the physiological substrate [1]. Also uses FAD and NADH but not NADPH.
History
EC 1.16.8.1 created 2004
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01100  Metabolic pathways
Orthology
K13786  cob(II)yrinic acid a,c-diamide reductase
Genes
MLO: mlr0087
MLN: A9174_24460
MCI: Mesci_4342
MOP: Mesop_4781
MAM: Mesau_04399
MAMO: A6B35_17930
MESO: BSQ44_14190
MESW: A9K65_024030
MES: Meso_1289
HOE: IMCC20628_01617
AMIH: CO731_03855(rutF)
SME: SMc00514
SMER: DU99_09595
SMD: Smed_1486
SFD: USDA257_c37830(rutF)
EAD: OV14_2932
ARA: Arad_2564
AVI: Avi_2423
RLG: Rleg_2123
RGA: RGR602_CH02074(rutF-1)
RHT: NT26_1871
NGL: RG1141_CH17090(rutF)
NGG: RG540_CH17480(rutF)
SHZ: shn_09200
BME: BMEI0709
BMEL: DK63_718
BMEE: DK62_136
BABR: DO74_603
BABT: DK49_1044
BABU: DK53_1271
BABS: DK51_189
BABC: DO78_1192
BMS: BR1292
BMT: BSUIS_A1342(hpaC)
BSZ: DK67_1006
BOV: BOV_1255
BCS: BCAN_A1315(hpaC)
BCAR: DK60_1331
BCAS: DA85_06200
BMR: BMI_I1305
BPP: BPI_I1344
BPV: DK65_88
OAN: Oant_1893
OAH: DR92_1381
BHE: BH09670(nmoB)
BHN: PRJBM_00937(nmoB)
BHS: BM1374165_01015(nmoB)
BQU: BQ07430(nmoB)
BQR: RM11_0704
BTR: BT_1346(nmoB)
BTX: BM1374166_01281(nmoB)
BGR: Bgr_11940(nmoB)
BCD: BARCL_0698(nmoB)
BVN: BVwin_08490(nmoB)
BANC: PU02_0932
FIL: BN1229_v1_3467(rutF)
FIY: BN1229_v1_2455(rutF)
MMED: Mame_03450(hpaC)
 » show all
Taxonomy
Reference
1  [PMID:1429467]
  Authors
Blanche F, Maton L, Debussche L, Thibaut D.
  Title
Purification and characterization of Cob(II)yrinic acid a,c-diamide reductase from Pseudomonas denitrificans.
  Journal
J Bacteriol 174:7452-4 (1992)
DOI:10.1128/JB.174.22.7452-7454.1992
Reference
2  [PMID:12195810]
  Authors
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
  Title
The biosynthesis of adenosylcobalamin (vitamin B12).
  Journal
Nat Prod Rep 19:390-412 (2002)
Other DBs
ExplorEnz - The Enzyme Database: 1.16.8.1
IUBMB Enzyme Nomenclature: 1.16.8.1
ExPASy - ENZYME nomenclature database: 1.16.8.1
BRENDA, the Enzyme Database: 1.16.8.1
CAS: 145539-93-1

DBGET integrated database retrieval system