KEGG   ENZYME: 1.17.2.2Help
Entry
EC 1.17.2.2                 Enzyme                                 

Name
lupanine 17-hydroxylase (cytochrome c);
lupanine dehydrogenase (cytochrome c)
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With a cytochrome as acceptor
BRITE hierarchy
Sysname
lupanine:cytochrome c-oxidoreductase (17-hydroxylating)
Reaction(IUBMB)
lupanine + 2 ferricytochrome c + H2O = 17-hydroxylupanine + 2 ferrocytochrome c + 2 H+ [RN:R09938]
Reaction(KEGG)
Substrate
lupanine [CPD:C10772];
ferricytochrome c [CPD:C00125];
H2O [CPD:C00001]
Product
17-hydroxylupanine [CPD:C20233];
ferrocytochrome c [CPD:C00126];
H+ [CPD:C00080]
Comment
The enzyme isolated from Pseudomonas putida contains heme c and requires pyrroloquinoline quinone (PQQ) for activity
History
EC 1.17.2.2 created 2012
Orthology
K21676  lupanine 17-hydroxylase (cytochrome c)
Genes
PMOS: O165_007235
PSPW: BJG93_33600 BJG93_33760
SWI: Swit_4160
Taxonomy
Reference
1  [PMID:1656935]
  Authors
Hopper DJ, Rogozinski J, Toczko M
  Title
Lupanine hydroxylase, a quinocytochrome c from an alkaloid-degrading Pseudomonas  sp.
  Journal
Biochem J 279 ( Pt 1):105-9 (1991)
  Sequence
Reference
2  [PMID:12686118]
  Authors
Hopper DJ, Kaderbhai MA
  Title
The quinohaemoprotein lupanine hydroxylase from Pseudomonas putida.
  Journal
Biochim Biophys Acta 1647:110-5 (2003)
DOI:10.1016/S1570-9639(03)00070-0
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.17.2.2
IUBMB Enzyme Nomenclature: 1.17.2.2
ExPASy - ENZYME nomenclature database: 1.17.2.2
BRENDA, the Enzyme Database: 1.17.2.2

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