KEGG   ENZYME: 1.18.1.4Help
Entry
EC 1.18.1.4                 Enzyme                                 

Name
rubredoxin---NAD(P)+ reductase;
rubredoxin-nicotinamide adenine dinucleotide (phosphate) reductase;
rubredoxin-nicotinamide adenine;
dinucleotide phosphate reductase;
NAD(P)+-rubredoxin oxidoreductase;
NAD(P)H-rubredoxin oxidoreductase
Class
Oxidoreductases;
Acting on iron-sulfur proteins as donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
rubredoxin:NAD(P)+ oxidoreductase
Reaction(IUBMB)
2 reduced rubredoxin + NAD(P)+ + H+ = 2 oxidized rubredoxin + NAD(P)H [RN:R02000 R02002]
Reaction(KEGG)
Substrate
reduced rubredoxin [CPD:C00340];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H+ [CPD:C00080]
Product
oxidized rubredoxin [CPD:C00435];
NADH [CPD:C00004];
NADPH [CPD:C00005]
Comment
The enzyme from Pyrococcus furiosus requires FAD. It reduces a number of electron carriers, including benzyl viologen, menadione and 2,6-dichloroindophenol, but rubredoxin is the most efficient. Ferredoxin is not utilized.
History
EC 1.18.1.4 created 1984, modified 2001, modified 2011
Pathway
ec00071  Fatty acid degradation
Reference
1  [PMID:6274224]
  Authors
Petitdemange H, Blusson H, Gay R.
  Title
Detection of NAD(P)H--rubredoxin oxidoreductases in Clostridia.
  Journal
Anal Biochem 116:564-70 (1981)
DOI:10.1016/0003-2697(81)90403-6
Reference
2  [PMID:10464233]
  Authors
Ma K, Adams MW.
  Title
A hyperactive NAD(P)H:Rubredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus.
  Journal
J Bacteriol 181:5530-3 (1999)
Other DBs
ExplorEnz - The Enzyme Database: 1.18.1.4
IUBMB Enzyme Nomenclature: 1.18.1.4
ExPASy - ENZYME nomenclature database: 1.18.1.4
BRENDA, the Enzyme Database: 1.18.1.4
CAS: 80237-97-4

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