KEGG   ENZYME: 1.18.1.5Help
Entry
EC 1.18.1.5                 Enzyme                                 

Name
putidaredoxin---NAD+ reductase;
putidaredoxin reductase;
camA (gene name)
Class
Oxidoreductases;
Acting on iron-sulfur proteins as donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
putidaredoxin:NAD+ oxidoreductase
Reaction(IUBMB)
reduced putidaredoxin + NAD+ = oxidized putidaredoxin + NADH + H+ [RN:R10048]
Reaction(KEGG)
Substrate
reduced putidaredoxin;
NAD+ [CPD:C00003]
Product
oxidized putidaredoxin [CPD:C03302];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Requires FAD. The enzyme from Pseudomonas putida reduces putidaredoxin. It contains a [2Fe-2S] cluster. Involved in the camphor monooxygenase system (see EC 1.14.15.1, camphor 5-monooxygenase).
History
EC 1.18.1.5 created 2012
Orthology
K21570  putidaredoxin---NAD+ reductase
Reference
1  [PMID:6401738]
  Authors
Roome PW Jr, Philley JC, Peterson JA
  Title
Purification and properties of putidaredoxin reductase.
  Journal
J Biol Chem 258:2593-8 (1983)
Reference
2  [PMID:2613690]
  Authors
Koga H, Yamaguchi E, Matsunaga K, Aramaki H, Horiuchi T
  Title
Cloning and nucleotide sequences of NADH-putidaredoxin reductase gene (camA) and  putidaredoxin gene (camB) involved in cytochrome P-450cam hydroxylase of Pseudomonas putida.
  Journal
J Biochem 106:831-6 (1989)
Reference
3  [PMID:2180940]
  Authors
Peterson JA, Lorence MC, Amarneh B
  Title
Putidaredoxin reductase and putidaredoxin. Cloning, sequence determination, and heterologous expression of the proteins.
  Journal
J Biol Chem 265:6066-73 (1990)
  Sequence
Reference
4  [PMID:12011076]
  Authors
Sevrioukova IF, Poulos TL
  Title
Putidaredoxin reductase, a new function for an old protein.
  Journal
J Biol Chem 277:25831-9 (2002)
DOI:10.1074/jbc.M201110200
  Sequence
Reference
5  [PMID:14529624]
  Authors
Sevrioukova IF, Garcia C, Li H, Bhaskar B, Poulos TL
  Title
Crystal structure of putidaredoxin, the [2Fe-2S] component of the P450cam monooxygenase system from Pseudomonas putida.
  Journal
J Mol Biol 333:377-92 (2003)
DOI:10.1016/j.jmb.2003.08.028
Reference
6  [PMID:15095867]
  Authors
Sevrioukova IF, Li H, Poulos TL
  Title
Crystal structure of putidaredoxin reductase from Pseudomonas putida, the final structural component of the cytochrome P450cam monooxygenase.
  Journal
J Mol Biol 336:889-902 (2004)
DOI:10.1016/j.jmb.2003.12.067
  Sequence
Reference
7  [PMID:15103126]
  Authors
Smith N, Mayhew M, Holden MJ, Kelly H, Robinson H, Heroux A, Vilker VL, Gallagher DT
  Title
Structure of C73G putidaredoxin from Pseudomonas putida.
  Journal
Acta Crystallogr D Biol Crystallogr 60:816-22 (2004)
DOI:10.1107/S0907444904003348
Other DBs
ExplorEnz - The Enzyme Database: 1.18.1.5
IUBMB Enzyme Nomenclature: 1.18.1.5
ExPASy - ENZYME nomenclature database: 1.18.1.5
BRENDA, the Enzyme Database: 1.18.1.5

DBGET integrated database retrieval system