KEGG   ENZYME: 1.2.1.19Help
Entry
EC 1.2.1.19                 Enzyme                                 

Name
aminobutyraldehyde dehydrogenase;
gamma-guanidinobutyraldehyde dehydrogenase (ambiguous);
ABAL dehydrogenase;
4-aminobutyraldehyde dehydrogenase;
4-aminobutanal dehydrogenase;
gamma-aminobutyraldehyde dehydroganase;
1-pyrroline dehydrogenase;
ABALDH;
YdcW
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
4-aminobutanal:NAD+ 1-oxidoreductase
Reaction(IUBMB)
4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+ [RN:R02549]
Reaction(KEGG)
R02549;
(other) R00904
Show
Substrate
4-aminobutanal [CPD:C00555];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
4-aminobutanoate [CPD:C00334];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates [9]. The plant enzyme also acts on 4-guanidinobutanal (cf. EC 1.2.1.54 gamma-guanidinobutyraldehyde dehydrogenase). As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate. The enzyme forms part of the arginine-catabolism pathway [8] and belongs in the aldehyde dehydrogenase superfamily [9].
History
EC 1.2.1.19 created 1965, modified 1989 (EC 1.5.1.35 created 2006, incorporated 2007)
Pathway
ec00330  Arginine and proline metabolism
ec00410  beta-Alanine metabolism
ec01100  Metabolic pathways
Orthology
K00137  aminobutyraldehyde dehydrogenase
Genes
ECO: b1444(patD)
ECJ: JW1439(ydcW)
ECD: ECDH10B_1574(ydcW)
EBW: BWG_1269(ydcW)
ECOK: ECMDS42_1163(ydcW)
ECE: Z2275
ECS: ECs2048
ECF: ECH74115_2050(ydcW)
ETW: ECSP_1924(ydcW)
ELX: CDCO157_1893
EOJ: ECO26_2043(ydcW)
EOI: ECO111_1833(ydcW)
EOH: ECO103_1574(ydcW)
ECG: E2348C_1584(ydcW)
EOK: G2583_1805(ydcW)
ESO: O3O_12355
ESM: O3M_13240
ESL: O3K_13275
ECW: EcE24377A_1624(ydcW)
ELH: ETEC_1515
EUN: UMNK88_1847(ydcW)
ECC: c1869(ydcW)
ECP: ECP_1446
ECI: UTI89_C1663(ydcW)
ECV: APECO1_586(ydcW)
ECX: EcHS_A1528(ydcW)
ECM: EcSMS35_1729(ydcW)
ECY: ECSE_1526
ECR: ECIAI1_1440(ydcW)
ECQ: ECED1_1598(ydcW)
ECK: EC55989_1576(ydcW)
EOC: CE10_1637(prr)
EUM: ECUMN_1692(ydcW)
ECZ: ECS88_1538(ydcW)
ELO: EC042_1572(ydcW)
ESE: ECSF_1368
EBR: ECB_01401(ydcW)
EBD: ECBD_2195
EKF: KO11_15460(prr)
EAB: ECABU_c16740(ydcW)
EDJ: ECDH1ME8569_1387(ydcW)
EIH: ECOK1_1607(ydcW)
ENA: ECNA114_1580(ydcW)
ELW: ECW_m1572(ydcW)
ELL: WFL_07695(prr)
ELC: i14_1692(ydcW)
ELD: i02_1692(ydcW)
ELP: P12B_c1683(ydcW)
EBL: ECD_01401(patD)
EBE: B21_01412(ydcW)
ELF: LF82_2806(ydcW)
ECOI: ECOPMV1_01587(prr)
ECOJ: P423_08095
ECOS: EC958_1719(ydcW)
EFE: EFER_1518(ydcW)
EAL: EAKF1_ch0051c(ydcW)
EMA: C1192_05170(patD)
STY: STY1467
STT: t1506
STM: STM1597(ydcW)
SEO: STM14_1934(ydcW)
SEY: SL1344_1528(ydcW)
SEJ: STMUK_1566(ydcW)
SEB: STM474_1610(ydcW)
SENI: CY43_08160
SPT: SPA1271(ydcW)
SEK: SSPA1179
SEI: SPC_2138(ydcW)
SEC: SCH_1594(ydcW)
SEH: SeHA_C1777(ydcW)
SHB: SU5_02211
SEE: SNSL254_A1712(ydcW)
SEW: SeSA_A1715(ydcW)
SEA: SeAg_B1563(ydcW)
SENS: Q786_07235
SED: SeD_A1744
SEG: SG1526(ydcW)
SEL: SPUL_1408(ydcW)
SEGA: SPUCDC_1408(ydcW)
SET: SEN1458(ydcW)
SENA: AU38_07530
SENO: AU37_07525
SENV: AU39_07535
SENQ: AU40_08455
SENL: IY59_07720
SENB: BN855_16440(ydcW)
SENE: IA1_07915
SBG: SBG_1421
SBZ: A464_1629
SFL: SF1774
SFX: S1905
SFV: SFV_1770
SFE: SFxv_1981(ydcW)
SFN: SFy_2539
SFS: SFyv_2596
SSN: SSON_1693
SDY: SDY_1730
ENC: ECL_01853
EEC: EcWSU1_02398(prr)
ECLX: LI66_11420
ECLY: LI62_13565
ECLZ: LI64_10745
ECAN: CWI88_11005(patD)
ESA: ESA_01928
CSK: ES15_2084(prr)
CTU: CTU_20580
KPN: KPN_01924(ydcW)
KPU: KP1_2989(ydcW)
KPP: A79E_2324
KPT: VK055_0557(ydcW)
KPE: KPK_2428(ydcW)
KPR: KPR_2955(prr)
KPJ: N559_2365
KPX: PMK1_04265(prr)
KPNU: LI86_11765
KPNK: BN49_3019(prr)
KVA: Kvar_2381
KOX: KOX_19750
KOE: A225_2819
EAE: EAE_20130
EAR: CCG29854
KQV: B8P98_12870(patD)
CKO: CKO_01478
CRO: ROD_15901(ydcW)
CBRA: A6J81_04620(patD)
CWE: CO701_10040(patD)
CYO: CD187_11530(patD)
CAMA: F384_07375
CAF: AL524_14890(patD)
CIF: AL515_12480(patD)
CFAR: CI104_13390(patD)
CIR: C2U53_22415(patD)
CIE: AN232_17625(patD)
EBT: EBL_c20140(ydcW)
RAO: DSD31_13715(patD)
LEI: C2U54_07560(patD) C2U54_16950(patD)
LEH: C3F35_09125(patD) C3F35_22970(patD)
LNI: CWR52_00270(patD)
LEW: DAI21_15130(patD)
EBF: D782_2273
EBC: C2U52_23480(patD)
SPE: Spro_3642
SRL: SOD_c35710(prr1) SOD_c35760(prr)
ECA: ECA1542
PATR: EV46_07800
PATO: GZ59_15800
PCT: PC1_1415
PEC: W5S_1731
SOD: Sant_1574
DDD: Dda3937_02687(ydcW)
DDQ: DDI_1241
DFN: CVE23_08255(patD)
PAEP: PA1S_14570
PAEM: U769_14170
PAEL: T223_15800
PAEG: AI22_19215
PCQ: PcP3B5_28820(prr_1) PcP3B5_38780(prr_2) PcP3B5_48730(prr_3) PcP3B5_48780(prr_4)
PPU: PP_1481(patD) PP_2801(prr)
PPF: Pput_4240
PPT: PPS_1133
PPX: T1E_2858
PPUT: L483_05275
PPUN: PP4_42310(prr)
PMON: X969_03830
PMOT: X970_03805
PEN: PSEEN1238
PPUU: PputUW4_01032(ydcW1) PputUW4_01037(ydcW2)
PKC: PKB_1111(prr1) PKB_1116(prr3) PKB_1908(prr5)
PSEC: CCOS191_2905(prr1) CCOS191_4196(prr2)
PSOS: POS17_1125 POS17_1130(ydcW)
PSIL: PMA3_04540
AHA: AHA_3818
AVR: B565_1619
AMED: B224_0217
ASR: WL1483_3009(prr)
SALN: SALB1_0908
BMA: BMAA1451
BMAE: DM78_4036(prr)
BMAI: DM57_08630
BMAF: DM51_5089
BMAZ: BM44_4917(prr)
BMAB: BM45_3819
BPS: BPSS0307
BPSE: BDL_3537(prr)
BPSM: BBQ_5893(prr)
BPSU: BBN_3702(prr)
BPSD: BBX_5376(prr)
BPK: BBK_5518(prr)
BPSH: DR55_5041(prr)
BPSA: BBU_5812(prr)
BPSO: X996_4810(prr)
BUT: X994_4310(prr)
BTQ: BTQ_5372(prr)
BTJ: BTJ_4026(prr)
BTZ: BTL_4847(prr)
BTD: BTI_4424(prr) BTI_5265(prr)
BTV: BTHA_5382(prr)
BTHE: BTN_4498(prr)
BTHM: BTRA_4764(prr)
BTHA: DR62_4611
BTHL: BG87_4829
BOK: DM82_4312(prr)
BOC: BG90_3705
BCON: NL30_36220
BUB: BW23_6326
BUL: BW21_4915
PLG: NCTC10937_01417(prr)
HYF: DTO96_101674(prr)
VEI: Veis_3304
HYB: Q5W_03780
MEH: M301_1034
DAL: Dalk_4031
MLO: mlr5385
AMIH: CO731_02107(prr)
SME: SMc01656
SMI: BN406_02092(prr)
SMER: DU99_12695
SMD: Smed_2191
SFD: USDA257_c45650(prr)
SIX: BSY16_532
SAME: SAMCFNEI73_Ch2536(prr)
EAD: OV14_3699
ARA: Arad_3974
REL: REMIM1_CH03741(prr)
REP: IE4803_CH04050(prr)
REI: IE4771_CH03991(prr)
RLE: RL4194
RLG: Rleg_3727
RGA: RGR602_CH03580(prr)
RHN: AMJ98_CH03896(prr)
RPHA: AMC79_CH03853(prr-1) AMC79_PD00734(prr-2)
RHX: AMK02_CH03783(prr)
RHK: Kim5_CH04027(prr-1) Kim5_PD00138(prr-2)
SHZ: shn_12175
OAN: Oant_2792
OAH: DR92_3754
SNO: Snov_0502
HDI: HDIA_4501(prr)
SPSE: SULPSESMR1_01346(prr)
ACR: Acry_2390
LPIL: LIP_2085
CGY: CGLY_02535(prr)
CAMG: CAMM_03485
NFA: NFA_12730
SBH: SBI_01548
ACH: Achl_3584
CWO: Cwoe_2601
MRB: Mrub_0152
 » show all
Taxonomy
Reference
1  [PMID:4817964]
  Authors
Callewaert DM, Rosemblatt MS, Tchen TT.
  Title
Purification and properties of 4-aminobutanal dehydrogenase from a Pseudomonas species.
  Journal
J Biol Chem 249:1737-41 (1974)
Reference
2
  Authors
Jakoby, W.B.
  Title
Aldehyde dehydrogenases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
Reference
3  [PMID:13673029]
  Authors
JAKOBY WB, FREDERICKS J.
  Title
Pyrrolidine and putrescine metabolism: gamma-aminobutyraldehyde dehydrogenase.
  Journal
J Biol Chem 234:2145-50 (1959)
Reference
4  [PMID:16663901]
  Authors
Matsuda H, Suzuki Y.
  Title
gamma-Guanidinobutyraldehyde Dehydrogenase of Vicia faba Leaves.
  Journal
Plant Physiol 76:654-657 (1984)
Reference
5
  Authors
Yorifuji, T., Koike, K., Sakurai, T. and Yokoyama, K.
  Title
4-Aminobutyraldehyde and 4-guanidinobutyraldehyde dehydrogenases for arginine degradation in Pseudomonas putida.
  Journal
Agric Biol Chem 50:2009-2016 (1986)
Reference
6  [PMID:3510672]
  Authors
Prieto-Santos MI, Martin-Checa J, Balana-Fouce R, Garrido-Pertierra A.
  Title
A pathway for putrescine catabolism in Escherichia coli.
  Journal
Biochim Biophys Acta 880:242-4 (1986)
DOI:10.1016/0304-4165(86)90085-1
Reference
7  [PMID:3129020]
  Authors
Prieto MI, Martin J, Balana-Fouce R, Garrido-Pertierra A.
  Title
Properties of gamma-aminobutyraldehyde dehydrogenase from Escherichia coli.
  Journal
Biochimie 69:1161-8 (1987)
DOI:10.1016/0300-9084(87)90142-8
Reference
8  [PMID:16023116]
  Authors
Samsonova NN, Smirnov SV, Novikova AE, Ptitsyn LR.
  Title
Identification of Escherichia coli K12 YdcW protein as a gamma-aminobutyraldehyde dehydrogenase.
  Journal
FEBS Lett 579:4107-12 (2005)
DOI:10.1016/j.febslet.2005.06.038
  Sequence
[eco:b1444]
Reference
9  [PMID:15381418]
  Authors
Gruez A, Roig-Zamboni V, Grisel S, Salomoni A, Valencia C, Campanacci V, Tegoni M, Cambillau C
  Title
Crystal structure and kinetics identify Escherichia coli YdcW gene product as a medium-chain aldehyde dehydrogenase.
  Journal
J Mol Biol 343:29-41 (2004)
DOI:10.1016/j.jmb.2004.08.030
  Sequence
[eco:b1444]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.19
IUBMB Enzyme Nomenclature: 1.2.1.19
ExPASy - ENZYME nomenclature database: 1.2.1.19
BRENDA, the Enzyme Database: 1.2.1.19
CAS: 9028-98-2

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