KEGG   ENZYME: 1.2.1.26Help
Entry
EC 1.2.1.26                 Enzyme                                 

Name
2,5-dioxovalerate dehydrogenase;
2-oxoglutarate semialdehyde dehydrogenase;
alpha-ketoglutaric semialdehyde dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2,5-dioxopentanoate:NADP+ 5-oxidoreductase
Reaction(IUBMB)
2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + 2 H+ [RN:R00264]
Reaction(KEGG)
Substrate
2,5-dioxopentanoate [CPD:C00433];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
2-oxoglutarate [CPD:C00026];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.2.1.26 created 1972
Pathway
ec00040  Pentose and glucuronate interconversions
ec00053  Ascorbate and aldarate metabolism
Orthology
K13877  2,5-dioxopentanoate dehydrogenase
K19588  2,5-dioxopentanoate dehydrogenase
Genes
PHD: 102329880
EAS: Entas_0544
KPK: A593_14040
KPY: KPNIH31_04595
KPE: KPK_4822(aldH)
KPI: D364_24440
KVA: Kvar_4455
KVD: KR75_11490
KVQ: SP68_18125
KQU: AVR78_07845
EAE: EAE_10400
EAR: CCG31914
CRO: ROD_25491
SPE: Spro_1837
SRL: SOD_c16630(aldH)
SPLY: Q5A_009095
SMAF: D781_1747
SMAR: SM39_1305
SERF: L085_19540
SOD: Sant_2373(aldH)
PES: SOPEG_1553(aldH)
EPY: EpC_10390
EAM: EAMY_2587
EAY: EAM_2482
PLU: plu2246
PAY: PAU_02153
XCV: XCV2743
XAX: XACM_2526
XAC: XAC2546
XCI: XCAW_02225(putA)
XOO: XOO3136(PutA)
XOM: XOO2978(XOO2978)
XOP: PXO_01440
XOR: XOC_1910
XAL: XALC_1961
XPH: XppCFBP6546_19685(XppCFBP6546P_19685)
LEZ: GLE_4607
LEM: LEN_0614
VPA: VP1329
VPB: VPBB_1253
VAG: N646_0363
PMY: Pmen_0227
PMK: MDS_0274
PSB: Psyr_3157
PSYR: N018_15855
PFL: PFL_1415(aldH_1) PFL_1528(aldH_2)
PPRC: PFLCHA0_c14520(aldH1) PFLCHA0_c15670(aldH2)
PFC: PflA506_2248(aldH_1) PflA506_2820(aldH_2)
PSTT: CH92_12560
PKC: PKB_3090
PSEC: CCOS191_2359(aldH1) CCOS191_3998(aldH2b)
PSOS: POS17_1438
ACX: Achr_3120
ABM: ABSDF1409
ACC: BDGL_000382(aldH) BDGL_000678(aldH) BDGL_001258(aldH) BDGL_001259(aldH) BDGL_001316(aldH)
ACI: ACIAD0131
SAZ: Sama_1529
SLO: Shew_2364
SSE: Ssed_1760
SPL: Spea_1702
SHL: Shal_2557
SWD: Swoo_2824
SWP: swp_1982
SVO: SVI_1708
SPSW: Sps_03407
CPS: CPS_1451(aldH)
PSEO: OM33_13460
PSPO: PSPO_a2279(aldH)
PTU: PTUN_a1049(aldH)
PSEN: PNC201_08060(aldH)
FBL: Fbal_2402
SAGA: M5M_19245
CSA: Csal_1140
CVI: CV_2824
PSE: NH8B_1450
RSO: RSp0827
RSL: RPSI07_mp0771(aldH)
RSN: RSPO_m01145(aldH)
RSM: CMR15_mp10803(aldH)
RSE: F504_4392
RPI: Rpic_4451
REH: H16_B0130(h16_B0130) H16_B0212(h16_B0212) H16_B0322(h16_B0322)
CNC: CNE_2c01150 CNE_2c01970(aldH1) CNE_2c03400(aldH2)
RME: Rmet_0832(aldH)
CGD: CR3_0768(aldH) CR3_3976(aldH)
BMAL: DM55_3664
BMAQ: DM76_4360
BXE: Bxe_B1805
BXB: DR64_7111
PPNO: DA70_20740
PPNM: LV28_09635
PPUL: RO07_03810
PSPU: NA29_24800
PAPI: SG18_03990
PLG: NCTC10937_02223(aldH_1) NCTC10937_02839(aldH_2)
BPA: BPP2085
BPAR: BN117_1238
BBR: BB1481
BPT: Bpet1258
AXX: ERS451415_02953(aldH)
AMIM: MIM_c20070
AAA: Acav_4664
ACRA: BSY15_1620
LCH: Lcho_2460
MXA: MXAN_6204
SCL: sce8242(aldH)
MES: Meso_0844
SME: SM_b20262
SMI: BN406_06404(aldH)
SMER: DU99_32060
EAD: OV14_b0363(hpaE)
ATU: Atu3259
ARA: Arad_4081
ATF: Ach5_31040(aldH)
AVI: Avi_3912
RLE: RL2296(aldH) pRL120235
RIR: BN877_II1588(aldH)
SHZ: shn_20840
XAU: Xaut_3374
MAQU: Maq22A_c11780(putA) Maq22A_c17960(putA)
BID: Bind_3078
MMED: Mame_00342(aldH_1) Mame_00561(aldH_2) Mame_00810(aldH_3)
HDI: HDIA_4619(aldH_1) HDIA_P0039(aldH_2)
CCR: CC_2791
CSE: Cseg_0982
SIL: SPOA0260
RSP: RSP_3656
PAMN: pAMV1p0046(araE)
DSH: Dshi_2442(aldH1)
KVL: KVU_0810
PSF: PSE_p0205
OTM: OSB_21610
PTP: RCA23_c06710(aldH)
CID: P73_1648
RHC: RGUI_2119
SPSE: SULPSESMR1_03843(gabD)
LVS: LOKVESSMR4R_03076(astD)
SPHU: SPPYR_0552(aldH)
SPHM: G432_06470
STAX: MC45_10350
SPHI: TS85_16940
SSAN: NX02_07120
SSY: SLG_18210
SPMI: K663_01045
SPHB: EP837_01502(aldH)
SPHR: BSY17_2380
SINB: SIDU_10705
SPHT: K426_16890
AAY: WYH_02188(aldH)
ADO: A6F68_00834(aldH)
ACR: Acry_0197
TMO: TMO_a0251(aldH) TMO_a0252
MMC: Mmcs_4783
MKM: Mkms_4869
MJL: Mjls_5169
MVA: Mvan_1031
CGL: NCgl0437(Cgl0452)
CGB: cg0535
CGU: WA5_0437
CGT: cgR_0525
CGM: cgp_0535
CGJ: AR0_02810
CAMG: CAMM_01105
NFA: NFA_35030
NFR: ERS450000_00547(aldH)
ROP: ROP_36470
RHB: NY08_3285
GOR: KTR9_2911
SMAL: SMALA_8024
ART: Arth_0036
ARR: ARUE_232p01560(aldH)
ACH: Achl_0350
IDO: I598_2355
NCA: Noca_4199
PSIM: KR76_03115
NDA: Ndas_2498
SEN: SACE_0343
PSEE: FRP1_25195
ACTI: UA75_23150
ACAD: UA74_22630
AHG: AHOG_20555(aldH2)
HAU: Haur_2504
OTE: Oter_2670
OBG: Verru16b_02510(aldH)
RBA: RB8941
PSL: Psta_0398
PIR: VN12_22435(aldH)
PLM: Plim_1474
PLS: VT03_00695(aldH)
FMR: Fuma_03966(aldH)
GES: VT84_29740(aldH)
ACA: ACP_2733(aldH)
CPI: Cpin_5585
SMIZ: 4412673_01388(aldH)
MUC: MuYL_0982
SLI: Slin_1008
LBY: Lbys_1775
FAE: FAES_4421(aldH)
PSEZ: HME7025_01775(aldH)
GFL: GRFL_0581
ZPR: ZPR_1384
MARM: YQ22_13925
CBAL: M667_17525
CBAT: M666_17530
DDO: I597_0361
ZGA: ZOBELLIA_4011(aldH)
MLT: VC82_2607
EAO: BD94_2187
ELB: VO54_00506(aldH)
CHZ: CHSO_2634(aldH)
WIN: WPG_1844
TMAR: MARIT_0673
MARF: CJ739_3132
FBU: UJ101_02217(aldH)
HHB: Hhub_4009
HMA: rrnAC3036(aldY3)
HHI: HAH_0292(aldY3)
HVO: HVO_B0039(xacF) HVO_B0100(aldY3)
HLA: Hlac_2240
NAT: NJ7G_1012
SSO: SSO3117(aldhT)
SOL: Ssol_0859
SSOA: SULA_0895
SSOL: SULB_0897
SSOF: SULC_0896
SID: M164_2247
SII: LD85_2520
SIH: SiH_2189
SIR: SiRe_2130
SIC: SiL_2094
CMA: Cmaq_1779
VMO: VMUT_1240
 » show all
Taxonomy
Reference
1  [PMID:6024771]
  Authors
Adams E, Rosso G
  Title
Alpha-ketoglutaric semialdehyde dehydrogenase of Pseudomonas. Properties of the purified enzyme induced by hydroxyproline and of the glucarate-induced and constitutive enzymes.
  Journal
J Biol Chem 242:1802-14 (1967)
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.26
IUBMB Enzyme Nomenclature: 1.2.1.26
ExPASy - ENZYME nomenclature database: 1.2.1.26
BRENDA, the Enzyme Database: 1.2.1.26
CAS: 37250-92-3

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